Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Karen Peynshaert"'
Autor:
Kaat De Clerck, Geraldine Accou, Félix Sauvage, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut, Karen Peynshaert
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1716 (2022)
The inner limiting membrane (ILM) represents a major bottleneck hampering efficient drug delivery to the retina after intravitreal injection. To overcome this barrier, we intend to perforate the ILM by use of a light-based approach which relies on th
Externí odkaz:
https://doaj.org/article/cf040bed09cd49c3ba48e33ada5d456b
Autor:
Karen Peynshaert, Joke Devoldere, Valérie Forster, Serge Picaud, Christian Vanhove, Stefaan C. De Smedt, Katrien Remaut
Publikováno v:
Drug Delivery, Vol 24, Iss 1, Pp 1384-1394 (2017)
Retinal gene delivery via intravitreal injection is hampered by various physiological barriers present in the eye of which the vitreoretinal (VR) interface represents the most serious hurdle. In this study, we present a retinal explant model especial
Externí odkaz:
https://doaj.org/article/f88c2ea9df46469e9518a08a7dfd7990
Autor:
An-Katrien Minnaert, Joke Devoldere, Karen Peynshaert, Laure Vercruysse, Stefaan C. De Smedt, Katrien Remaut
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 74 (2021)
In the last few years, interest has grown in the use of nucleic acids as an ocular therapy for retinal genetic diseases. Recently, our research group has demonstrated that mRNA delivery could result in effective protein expression in ocular cells fol
Externí odkaz:
https://doaj.org/article/3c0ba6becfed4b36b5231e67f8ab7738
Publikováno v:
EXPERT OPINION ON DRUG DELIVERY
Introduction Retinal disease affects millions of people worldwide, generating a massive social and economic burden. Current clinical trials for retinal diseases are dominated by gene augmentation therapies delivered with recombinant viruses as key pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31c0c593934a350d472871510d65b97
https://doi.org/10.1080/17425247.2023.2167979
https://doi.org/10.1080/17425247.2023.2167979
Autor:
Tatu Lajunen, Joke Devoldere, Shirin Tavakoli, Marika Ruponen, Eva M. del Amo, Karen Peynshaert, Stefaan C. De Smedt, Katrien Remaut, Arto Urtti
Publikováno v:
Journal of controlled release
JOURNAL OF CONTROLLED RELEASE
JOURNAL OF CONTROLLED RELEASE
Drug delivery to the posterior segment of the eye is challenging due to several anatomical and physiological barriers. Thus, there is a need for prolonged action and targeted drug delivery to treat retinal diseases. Intravitreal injections avoid ante
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c8520e801a22f8125da25cea3f87c3
https://doi.org/10.1016/j.jconrel.2020.10.028
https://doi.org/10.1016/j.jconrel.2020.10.028
Autor:
Karen Peynshaert, Helena Vanluchene, Kaat De Clerck, An-Katrien Minnaert, Morgane Verhoeven, Noémie Gouspillou, Nezahat Bostan, Toshio Hisatomi, Geraldine Accou, Félix Sauvage, Kevin Braeckmans, Stefaan De Smedt, Katrien Remaut
Publikováno v:
Journal of controlled release
Many groundbreaking therapies for the treatment of blindness require delivery of biologics or cells to the inner retina by intravitreal injection. Unfortunately, the advancement of these therapies is greatly hampered by de-livery difficulties where o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8de663762b6f1827242bc58f5251319
Autor:
Félix Sauvage, Van Phuc Nguyen, Yanxiu Li, Aranit Harizaj, J. Sebag, Dimitri Roels, Viktor Van Havere, Karen Peynshaert, Ranhua Xiong, Juan C. Fraire, Marie-José Tassignon, Katrien Remaut, Yannis M. Paulus, Kevin Braeckmans, Stefaan C. De Smedt
Publikováno v:
Nature nanotechnology
NATURE NANOTECHNOLOGY
NATURE NANOTECHNOLOGY
Vitreous opacities, which are collagen aggregates that form in the eye and cause vision impairment (eye floaters), are currently treated with invasive surgical intervention or high-energy laser photoablation. In this paper, the authors show that expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c314eca6897cf669ade8bf8c2a19e1
https://pubmed.ncbi.nlm.nih.gov/35302088
https://pubmed.ncbi.nlm.nih.gov/35302088
Autor:
Karen Peynshaert, Joke Devoldere, Stefaan C. De Smedt, Heleen Dewitte, Katrien Remaut, Mike Wels
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 141:161-171
Considerable research over the last few years has revealed dysregulation of growth factors in various retinal diseases, such as glaucoma, diabetic retinopathy and photoreceptor degenerations. The use of messengerRNA (mRNA) to transiently overexpress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3522963cb7e4715dacf3430ca41a926
https://doi.org/10.1016/j.ejpb.2019.05.023
https://doi.org/10.1016/j.ejpb.2019.05.023
Publikováno v:
Drug Discovery Today. 24:1483-1498
Müller cells are specialized glial cells that span the entire retina from the vitreous cavity to the subretinal space. Their functional diversity and unique radial morphology render them particularly interesting targets for new therapeutic approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec076675aa81598adf4de650821d13f
https://doi.org/10.1016/j.drudis.2019.01.023
https://doi.org/10.1016/j.drudis.2019.01.023
Publikováno v:
Current Eye Research. 44:465-475
The inner limiting membrane (ILM) represents the structural boundary between the vitreous and the retina, and is suggested to act as a barrier for a wide range of retinal therapies. While it is widely acknowledged that the morphology of the human ILM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80be4c1bb8640a2a3ab2af1de5a226a5
https://doi.org/10.1080/02713683.2019.1565890
https://doi.org/10.1080/02713683.2019.1565890