Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Karen P, Briski"'
Glucose transporter-2 regulation of VMN GABA neuron metabolic sensor and transmitter gene expression
Autor:
Sagor C. Roy, Subash Sapkota, Madhu Babu Pasula, Sushma Katakam, Rami Shrestha, Karen P. Briski
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Glucose transporter-2 (GLUT2) monitors cellular glucose uptake. Astrocyte GLUT2 controls glucose counterregulatory hormone secretion. In vivo gene silencing and laser-catapult-microdissection tools were used here to investigate whether ventr
Externí odkaz:
https://doaj.org/article/9cf90b33920c4bfea80e0a4ee1331ad3
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 635-642 (2024)
Recent studies documented regulation of hypothalamic astrocyte mitogen-activated protein kinase (MAPK) pathways, including p38, by the plasma membrane glucose carrier/sensor glucose transporter-2 (GLUT2). Sex-specific GLUT2 control of p38 phosphoryla
Externí odkaz:
https://doaj.org/article/c459059be2fa4c09a22e045c51cd118b
Autor:
Madhu Babu Pasula, Sagor C. Roy, Khaggeswar Bheemanapally, Paul W. Sylvester, Karen P. Briski
Publikováno v:
Neuroglia, Vol 4, Iss 3, Pp 158-171 (2023)
The plasma membrane glucose transporter (GLUT)-2 is unique among GLUT family proteins in that it also functions as a glucose sensor. GLUT2 imposes sex-dimorphic control of hypothalamic astrocyte glucose storage and catabolism by unknown mechanisms. M
Externí odkaz:
https://doaj.org/article/344773b9bd5f4392826e74911f1370a9
Publikováno v:
ASN Neuro, Vol 15 (2023)
Pharmacological stimulation/antagonism of astrocyte glio-peptide octadecaneuropeptide signaling alters ventromedial hypothalamic nucleus (VMN) counterregulatory γ-aminobutyric acid (GABA) and nitric oxide transmission. The current research used newl
Externí odkaz:
https://doaj.org/article/67c4b34cbe2f4014a9e8f657dff7bc34
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 38-46 (2022)
Hindbrain A2 noradrenergic neurons assimilate estrogenic and metabolic cues. In female mammals, negative- versus positive-feedback patterns of estradiol (E) secretion impose divergent regulation of the gonadotropin-releasing hormone (GnRH)-pituitary-
Externí odkaz:
https://doaj.org/article/65d7437175f945e5bbd4c6709de5cc32
Autor:
Karen P. Briski, Prabhat R. Napit, Abdulrahman Alhamyani, Jérôme Leprince, A.S.M. Hasan Mahmood
Publikováno v:
ASN Neuro, Vol 15 (2023)
Central endozepinergic signaling is implicated in glucose homeostasis. Ventromedial hypothalamic nucleus (VMN) metabolic monitoring governs glucose counter-regulation. VMN glucose-stimulatory nitric oxide (NO) and glucose-inhibitory γ-aminobutyric a
Externí odkaz:
https://doaj.org/article/0a33517431af4e798a870ea4a71f61ed
Publikováno v:
AIMS Neuroscience, Vol 8, Iss 4, Pp 510-525 (2021)
Gamma-aminobutyric acid (GABA) acts on ventromedial hypothalamic targets to suppress counter-regulatory hormone release, thereby lowering blood glucose. Maladaptive up-regulation of GABA signaling is implicated in impaired counter-regulatory outflow
Externí odkaz:
https://doaj.org/article/e5c981b3b0f343cda58add9656d98cc8
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Astrocyte glycogen, the primary energy reserve in brain, undergoes continuous remodeling by glucose passage through the glycogen shunt prior to conversion to the oxidizable energy fuel l-lactate. Glucogenic amino acids (GAAs) are a potential
Externí odkaz:
https://doaj.org/article/e4b858a45e394e799d3b44841f5da804
Autor:
MD Main Uddin, Karen P Briski
Publikováno v:
AIMS Neuroscience, Vol 8, Iss 1, Pp 133-147 (2021)
Hypoglycemia activates the ultra-sensitive energy gauge 5′-AMP-activated protein kinase (AMPK) in ventromedial hypothalamic nucleus (VMN) gluco-regulatory neurons. The VMN is exemplified by high levels of expression of the enzyme aromatase, which c
Externí odkaz:
https://doaj.org/article/7d4ac174d7e74e5ab4a35340f08a216f
Autor:
Karen P. Briski, A. S. M. Hasan Mahmood, Md. Main Uddin, Mostafa M. H. Ibrahim, Khaggeswar Bheemanapally
Publikováno v:
Biology, Vol 12, Iss 2, p 242 (2023)
The enzyme aromatase is expressed at high levels in the ventromedial hypothalamic nucleus (VMN), a principal component of the brain gluco-regulatory network. Current research utilized selective gene knockdown tools to investigate the premise that VMN
Externí odkaz:
https://doaj.org/article/b9913fd2d90c4409b54e87c9e3498c05