Efficacy of Intravenously Administered Gepotidacin in Cynomolgus Macaques following a Francisella tularensis Inhalational Challenge

Autor: Charles Jakielaszek, Jamese J. Hilliard, Frank Mannino, Mohammad Hossain, Lian Qian, Cindy Fishman, Ying-Liang Chou, Lisa Henning, Joseph Novak, Samandra Demons, Jeremy Hershfield, Karen O’Dwyer

Publikováno v: Antimicrobial Agents and Chemotherapy. 67

Francisella tularensis ( F. tularensis ) is a Centers for Disease Control (CDC) category “A” Gram-negative biothreat pathogen. Inhalation of F. tularensis can cause pneumonia and respiratory failure and is associated with high mortality rates wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ad0e116cff5f18716edbe02bf982e4f
https://doi.org/10.1128/aac.01381-22

Development of the Novel Antibacterial Gepotidacin as a Potential Treatment of Pneumonic Plague

Autor: C. Jakielaszek, M. Hossain, L. Qian, C. Fishman, K. Widdowson, J. J. Hilliard, F. Mannino, A. Raychaudhuri, E. Carniel, H. Heine, J. Hershfield, R. Russo, W. Mega, D. Revelli, Karen O'Dwyer

Publikováno v: SSRN Electronic Journal.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc3b27d92f283e37ff9f29498e9ceb2a
https://doi.org/10.2139/ssrn.3588534

Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production

Autor: Catherine M. Collins, David W. Spence, Kate M. J. de Mattos-Shipley, Colin M. Lazarus, Amanda J. Hartley, Fabrizio Alberti, Andy M. Bailey, Karen O'Dwyer, Sreedhar Kilaru, Patrick L. Hayes, Russell J. Cox, Gary D. Foster, Christine L. Willis, Alison Michelle Griffin

Publikováno v: Scientific Reports
Bailey, A M, Alberti, F, Kilaru, S, Collins, C M, De Mattos-Shipley, K, Hartley, A J, Hayes, P, Griffin, A, Lazarus, C M, Cox, R J, Willis, C L, O'Dwyer, K, Spence, D W & Foster, G D 2016, ' Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production ', Scientific Reports, vol. 6, srep25202 . https://doi.org/10.1038/srep25202

Semi-synthetic derivatives of the tricyclic diterpene antibiotic pleuromutilin from the basidiomycete Clitopilus passeckerianus are important in combatting bacterial infections in human and veterinary medicine. These compounds belong to the only new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2903429b58858c5740d9e8ef58fd94a8
http://wrap.warwick.ac.uk/96721/1/WRAP-Identification-manipulation-pleuromutlin-gene-Alberti-2016.pdf

Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322

Autor: Donghui Qin, Meredith Hackel, Aubart Kelly M, Sarah Hightower, Karen O'Dwyer, D. L. Butler, Daryl J. Hoban, Magdalena Zalacain, Samuel K. Bouchillon

Publikováno v: Antimicrobial agents and chemotherapy. 57(5)

GSK1322322 is a novel peptide deformylase (PDF) inhibitor being developed for the intravenous and oral treatment of acute bacterial skin and skin structure infections and hospitalized patients with community-acquired pneumonia. The activity of GSK132

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8300a25112804e5df4b65dbce6152429
https://pubmed.ncbi.nlm.nih.gov/23478958

A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function

Autor: Alexander P. Bryant, Chi So, Serban Iordanescu, Sylvester Daniel R, Patrick Vernon Warren, David J. Holmes, James R. Brown, Jing Fan, Damien McDevitt, Craig Volker, Jennifer Ambrad, Leslie Marie Palmer, Sanjoy Biswas, Karen O'Dwyer, Frank Fan, Karen A. Ingraham, Magdalena Zalacain, R. Dwayne Lunsford, Martin Karl Russel Burnham, Alison F. Chalker

Publikováno v: Journal of molecular microbiology and biotechnology. 6(2)

Attempted allelic replacement of 144 Streptococcus pneumoniae open reading frames of previously uncharacterized function led to the identification of 36 genes essential for growth under laboratory conditions. Of these, 14 genes (obg, spoIIIJ2, trmU,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204cbc08cec079f27f6af9185a09ca9d
https://pubmed.ncbi.nlm.nih.gov/15044829