Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Karen N. Leung"'
Autor:
Malaika K. Singleton, Michael L. Gonzales, Karen N. Leung, Dag H. Yasui, Diane I. Schroeder, Keith Dunaway, Janine M. LaSalle
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 190-200 (2011)
Mutations in MECP2, encoding methyl CpG binding protein 2, cause the neurodevelopmental disorder Rett syndrome. MeCP2 is an abundant nuclear protein that binds to chromatin and modulates transcription in response to neuronal activity. Prior studies o
Externí odkaz:
https://doaj.org/article/74a7c1dbf40a48d98acaa0ac631b3437
Publikováno v:
Seminars in Cell & Developmental Biology. 56:3-8
In early female embryos X-chromosome inactivation occurs concomitant with up regulation of the non-coding RNA, Xist, on the future inactive X-chromosome. Up regulation of Xist and coating of the future inactive X is sufficient to induce silencing. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f5b3864314338ecc674fcacdf4366f
https://doi.org/10.1016/j.semcdb.2016.05.005
https://doi.org/10.1016/j.semcdb.2016.05.005
Autor:
Carolyn A. Larabell, Myan Do, Barbara Panning, Elizabeth A. Smith, Gerry McDermott, Karen N. Leung, Mark A. Le Gros
Publikováno v:
Biophysical journal, vol 107, iss 8
Soft x-ray tomography (SXT) is increasingly being recognized as a valuable method for visualizing and quantifying the ultrastructure of cryopreserved cells. Here, we describe the combination of SXT with cryogenic confocal fluorescence tomography (CFT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8c67c8a434d4e251f8c095955e166e
https://doi.org/10.1016/j.bpj.2014.09.011
https://doi.org/10.1016/j.bpj.2014.09.011
Publikováno v:
Human Molecular Genetics
Human molecular genetics, vol 18, iss 22
Human molecular genetics, vol 18, iss 22
Imprinting, non-coding RNA and chromatin organization are modes of epigenetic regulation that modulate gene expression and are necessary for mammalian neurodevelopment. The only two known mammalian clusters of genes encoding small nucleolar RNAs (sno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e845c32962256e5fe5b47bd77721425f
https://doi.org/10.1093/hmg/ddp373
https://doi.org/10.1093/hmg/ddp373
Autor:
N. J. Wang, David J Wu, N. C. Schanen, Jennette Driscoll, Amber Hogart, Janine M. LaSalle, Karen N. Leung, Roxanne O. Vallero
Publikováno v:
Journal of Medical Genetics. 46:86-93
Chromosome 15q11-13 contains a cluster of imprinted genes essential for normal mammalian neurodevelopment. Deficiencies in paternal or maternal 15q11-13 alleles result in Prader-Willi or Angelman syndromes, respectively, and maternal duplications lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d910f46f1cbb56b50dac3ffb3ad4aa49
https://doi.org/10.1136/jmg.2008.061580
https://doi.org/10.1136/jmg.2008.061580
Autor:
Karen N. Leung, Barbara Panning
Publikováno v:
Nature
The Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation (XCI), the process by which mammals compensate for unequal numbers of sex chromosomes. During XCI, Xist coats the future inactive X chromosome (Xi) and recruits Polycomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c5534fd17c84c053bcc1c339eac17a
https://pubmed.ncbi.nlm.nih.gov/24162848
https://pubmed.ncbi.nlm.nih.gov/24162848
Epigenetic mechanisms play essential roles in mammalian neurodevelopment and genetic mutations or chromosomal deletions or duplications of epigenetically regulated loci or pathways result in several important human neurodevelopmental disorders. Postn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f182b0a5f351bbd403a39e1baf6e151c
https://europepmc.org/articles/PMC3090268/
https://europepmc.org/articles/PMC3090268/
Autor:
Mark A. Le Gros, Elizabeth A. Smith, Gerry McDermott, Carolyn A. Larabell, Karen N. Leung, Barbara Panning
Publikováno v:
Biophysical Journal. 106(2):434a-435a
The three-dimensional topology and compaction profile of an individual chromosome likely influences the expression of its genes. We present the first high-resolution description of the structure of an individual chromosome, the inactive X chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2016309a07f40f211f79875dbeeca16a
Autor:
Michael L. Gonzales, Diane I. Schroeder, Keith W. Dunaway, Dag H. Yasui, Janine M. LaSalle, Karen N. Leung, Malaika K. Singleton
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 190-200 (2011)
Mutations in MECP2, encoding methyl CpG binding protein 2, cause the neurodevelopmental disorder Rett syndrome. MeCP2 is an abundant nuclear protein that binds to chromatin and modulates transcription in response to neuronal activity. Prior studies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdb95b38c1d1711d3a4d1f959fc9517
https://pubmed.ncbi.nlm.nih.gov/21420494
https://pubmed.ncbi.nlm.nih.gov/21420494
Publikováno v:
Tissue engineering. Part A. 16(6)
Current bioengineered bladder wall substitutes include acellular scaffolds and grafts seeded with autologous cells. The transplanted cells on a seeded graft may regenerate and/or be replaced by cells of the patient's bladder. This may or may not be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2be458482f648d5216dd7c50c8282f8
https://pubmed.ncbi.nlm.nih.gov/20109058
https://pubmed.ncbi.nlm.nih.gov/20109058