Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Karen N Conneely"'
Autor:
Suresh Venkateswaran, Hari K Somineni, Varun Kilaru, Seyma Katrinli, Jarod Prince, David T Okou, Jeffrey S Hyams, Lee A Denson, Richard Kellermayer, Greg Gibson, David J Cutler, Alicia K Smith, Subra Kugathasan, Karen N Conneely
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 4 (2022)
AbstractRecently, we identified 1,189 CpG sites whose DNA methylation level in blood associated with Crohn’s disease. Here, we examined associations between DNA methylation and genetic variants to identify methylation quantitative trait loci across
Externí odkaz:
https://doaj.org/article/dc395e1a91ec4b6bb6ee83b782ed4d3a
Autor:
Anna K Knight, Anne L Dunlop, Varun Kilaru, Dawayland Cobb, Elizabeth J Corwin, Karen N Conneely, Alicia K Smith
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204228 (2018)
During pregnancy, women experience numerous physiological changes but, to date, there is limited published data that characterize accompanying changes in gene expression over pregnancy. This study sought to characterize the complexity of the transcri
Externí odkaz:
https://doaj.org/article/a13611c99df54c8c831913859b2c2642
Autor:
Kenyaita M. Hodge, Amber A. Burt, Marie Camerota, Brian S. Carter, Jennifer Check, Karen N. Conneely, Jennifer Helderman, Julie A. Hofheimer, Anke Hüls, Elisabeth C. McGowan, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Sheri A. DellaGrotta, Lynne M. Dansereau, T. Michael O’Shea, Carmen J. Marsit, Barry M. Lester, Todd M. Everson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The time from conception through the first year of life is the most dynamic period in human development. This time period is particularly important for infants born very preterm (
Externí odkaz:
https://doaj.org/article/00ebc431d2c24149985591644f345a5d
Autor:
Andrew W Bergen, Martha Michel, Denise Nishita, Ruth Krasnow, Harold S Javitz, Karen N Conneely, Christina N Lessov-Schlaggar, Hyman Hops, Andy Z X Zhu, James W Baurley, Jennifer B McClure, Sharon M Hall, Timothy B Baker, David V Conti, Neal L Benowitz, Caryn Lerman, Rachel F Tyndale, Gary E Swan, Transdisciplinary Research in Cancer of the Lung Research Team
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0126113 (2015)
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme an
Externí odkaz:
https://doaj.org/article/482e4745ab7b45ce912e61d8e8237ff7
Autor:
Karen E Hermetz, Scott Newman, Karen N Conneely, Christa L Martin, Blake C Ballif, Lisa G Shaffer, Jannine D Cody, M Katharine Rudd
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004139 (2014)
Inverted duplications are a common type of copy number variation (CNV) in germline and somatic genomes. Large duplications that include many genes can lead to both neurodevelopmental phenotypes in children and gene amplifications in tumors. There are
Externí odkaz:
https://doaj.org/article/98cb361d57bb4a7581e7900cda9814ba
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101607 (2014)
Chromosome breakage in germline and somatic genomes gives rise to copy number variation (CNV) responsible for genomic disorders and tumorigenesis. DNA sequence is known to play an important role in breakage at chromosome fragile sites; however, the s
Externí odkaz:
https://doaj.org/article/1a4cb382d8dd484b95117e0454221ac9
Autor:
Sasha E Parets, Karen N Conneely, Varun Kilaru, Stephen J Fortunato, Tariq Ali Syed, George Saade, Alicia K Smith, Ramkumar Menon
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67489 (2013)
Spontaneous preterm birth (PTB,
Externí odkaz:
https://doaj.org/article/395c43f78a2d4bc5851c4c68feae6d75
Autor:
Junyu Chen, Evan Gatev, Todd Everson, Karen N. Conneely, Nastassja Koen, Michael P. Epstein, Michael S. Kobor, Heather J. Zar, Dan J. Stein, Anke Hüls
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Recent efforts have focused on developing methylation risk scores (MRS), a weighted sum of the individual’s DNA methylation (DNAm) values of pre-selected CpG sites. Most of the current MRS approaches that utilize Epigenome-wide association studies
Externí odkaz:
https://doaj.org/article/4babd77b39d246af9c962658b9fdc9ec
Autor:
Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith, Subra Kugathasan
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) pati
Externí odkaz:
https://doaj.org/article/775c2f58680944ca846097a854389076
Autor:
Sarah W. Curtis, Dawayland O. Cobb, Varun Kilaru, Metrecia L. Terrell, M. Elizabeth Marder, Dana Boyd Barr, Carmen J. Marsit, Michele Marcus, Karen N. Conneely, Alicia K. Smith
Publikováno v:
Epigenetics, Vol 16, Iss 3, Pp 338-352 (2021)
Exposure to polychlorinated biphenyls (PCBs), an endocrine-disrupting compound, is ubiquitous despite decades-old bans on the manufacture and use of PCBs. Increased exposure to PCBs is associated with adverse health consequences throughout life, incl
Externí odkaz:
https://doaj.org/article/7398b175a31b41458701e21d9175945e