Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Karen N Allen"'
Autor:
Jeremiah D Farelli, Brendan D Galvin, Zhiru Li, Chunliang Liu, Miyuki Aono, Megan Garland, Olivia E Hallett, Thomas B Causey, Alana Ali-Reynolds, Daniel J Saltzberg, Clotilde K S Carlow, Debra Dunaway-Mariano, Karen N Allen
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004245 (2014)
Parasitic nematodes are responsible for devastating illnesses that plague many of the world's poorest populations indigenous to the tropical areas of developing nations. Among these diseases is lymphatic filariasis, a major cause of permanent and lon
Externí odkaz:
https://doaj.org/article/56597a01f85b41e98e0b6236a99ece68
Autor:
Kevin G. Hicks, Ahmad A. Cluntun, Heidi L. Schubert, Sean R. Hackett, Jordan A. Berg, Paul G. Leonard, Mariana A. Ajalla Aleixo, Youjia Zhou, Alex J. Bott, Sonia R. Salvatore, Fei Chang, Aubrie Blevins, Paige Barta, Samantha Tilley, Aaron Leifer, Andrea Guzman, Ajak Arok, Sarah Fogarty, Jacob M. Winter, Hee-Chul Ahn, Karen N. Allen, Samuel Block, Iara A. Cardoso, Jianping Ding, Ingrid Dreveny, William C. Gasper, Quinn Ho, Atsushi Matsuura, Michael J. Palladino, Sabin Prajapati, Pengkai Sun, Kai Tittmann, Dean R. Tolan, Judith Unterlass, Andrew P. VanDemark, Matthew G. Vander Heiden, Bradley A. Webb, Cai-Hong Yun, Pengkai Zhao, Bei Wang, Francisco J. Schopfer, Christopher P. Hill, Maria Cristina Nonato, Florian L. Muller, James E. Cox, Jared Rutter
Publikováno v:
Science
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352755dceffe88559d81ce00a2f38a1e
https://doi.org/10.1126/science.abm3452
https://doi.org/10.1126/science.abm3452
Autor:
Samantha N. Muellers, Margarita A. Tararina, Uros Kuzmanovic, James E. Galagan, Karen N. Allen
Publikováno v:
Biochemistry. 62:851-862
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f857dd511fb3d512413b2abeb822220
https://doi.org/10.1021/acs.biochem.2c00540
https://doi.org/10.1021/acs.biochem.2c00540
Autor:
Christopher J. DiRusso, Anthony M. DeMaria, Judy Wong, Jack J. Jordanides, Adrian Whitty, Karen N. Allen, Thomas D. Gilmore
Publikováno v:
bioRxiv
Scaffold proteins help mediate interactions between protein partners, often to optimize intracellular signaling. Herein, we use comparative, biochemical, biophysical, molecular, and cellular approaches to investigate how the scaffold protein NEMO con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852d9fc4b75571ece11a99ac158db0b6
https://europepmc.org/articles/PMC10245932/
https://europepmc.org/articles/PMC10245932/
Publikováno v:
Protein Science. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5470502d909598e778f81ea8fd29af14
https://doi.org/10.1002/pro.4646
https://doi.org/10.1002/pro.4646
Autor:
Ayan Majumder, Nemanja Vuksanovic, Leah C. Ray, Hannah M. Bernstein, Karen N. Allen, Barbara Imperiali, John E. Straub
Complex glycans serve important functions in all living systems. Many of these intricate and byzantine biomolecules are assembled employing biosynthetic pathways wherein the constituent enzymes are membrane associated. A signature feature of the step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::734f66a0e470c0b1b11acdb0ed4ece9e
https://doi.org/10.1101/2023.05.07.539694
https://doi.org/10.1101/2023.05.07.539694
Autor:
Christian P. Whitman, Karen N. Allen
Publikováno v:
Biochemistry
Enzymes are categorized into superfamilies by sequence, structural, and mechanistic similarities. The evolutionary implications can be profound. Until the mid-1990s, the approach was fragmented largely due to limited sequence and structural data. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7458b9013fec784fde2719cb1c84979a
https://doi.org/10.1021/acs.biochem.1c00494
https://doi.org/10.1021/acs.biochem.1c00494
Autor:
Aaron B. Beeler, Karen N. Allen, Paula C Ortet, Samantha N Muellers, Blair R. Szymczyna, Lauren A Viarengo-Baker, Kristina Streu, Adrian Whitty
Publikováno v:
Journal of the American Chemical Society. 143:3779-3793
Macrocycles, including macrocyclic peptides, have shown promise for targeting challenging protein-protein interactions (PPIs). One PPI of high interest is between Kelch-like ECH-Associated Protein-1 (KEAP1) and Nuclear Factor (Erythroid-derived 2)-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeb66c0f3ef819fef5bc8572ab7fedc
https://doi.org/10.1021/jacs.0c09799
https://doi.org/10.1021/jacs.0c09799
Autor:
Christine M Harvey, Debra Dunaway-Mariano, Chunliang Liu, Karen N. Allen, Katherine H O'Toole, Patrick S. Mariano
Publikováno v:
Biochemistry. 59:3247-3257
Trehalose-6-phosphate phosphatase (T6PP) catalyzes the dephosphorylation of trehalose 6-phosphate (T6P) to the disaccharide trehalose. The enzyme is not present in mammals but is essential to the viability of multiple lower organisms as trehalose is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a994e55739cdb58a92df58bc4d049a63
https://doi.org/10.1021/acs.biochem.0c00317
https://doi.org/10.1021/acs.biochem.0c00317
Autor:
Hayley L. Knox, Karen N. Allen
Publikováno v:
Current Opinion in Chemical Biology. 72:102246
The use of protein sequence to inform enzymology in terms of structure, mechanism, and function has burgeoned over the past two decades. Referred to as genomic enzymology, the utilization of bioinformatic tools such as sequence similarity networks an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb79bfcab10e24c071f1af7d36cc347
https://doi.org/10.1016/j.cbpa.2022.102246
https://doi.org/10.1016/j.cbpa.2022.102246