Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Karen Mollet"'
Autor:
Matthias D’hooghe, Stéphanie Vandekerckhove, Karen Mollet, Karel Vervisch, Stijn Dekeukeleire, Liesbeth Lehoucq, Carmen Lategan, Peter J. Smith, Kelly Chibale, Norbert De Kimpe
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1745-1752 (2011)
A variety of 2-amino-3-arylpropan-1-ols, anti-2-amino-3-aryl-3-methoxypropan-1-ols and anti-2-amino-1-arylpropan-1,3-diols were prepared selectively through elaboration of trans-4-aryl-3-chloro-β-lactams. In addition, a number of 2-(azidomethyl)azir
Externí odkaz:
https://doaj.org/article/515f9c18d0674f819de108143b0f14f6
Autor:
Dietmar Hertsen, Sari Deketelaere, Lotte Demeurisse, Kristof Van Hecke, Veronique Van Speybroeck, Jelle De Moor, Elias Van Den Broeck, Hannelore Goossens, Lieselotte Crul, Nicola Piens, Matthias D'hooghe, Karen Mollet
Publikováno v:
CHEMISTRY-A EUROPEAN JOURNAL
The reactivity of 3-oxo-β-lactams with respect to primary amines was investigated in depth. Depending on the specific azetidin-2-one C4 substituent, this reaction was shown to selectively produce 3-imino-β-lactams (through dehydration), α-aminoami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1492bbc3ec976c32d0e8caf2719194
https://doi.org/10.1002/chem.201703852
https://doi.org/10.1002/chem.201703852
Autor:
Hang Dao Thi, Karen Mollet, Tuyen Van Nguyen, Matthias D'hooghe, Lena Decuyper, Sara Kenis, Norbert De Kimpe
Publikováno v:
Synlett. 27:1100-1105
This paper reports on the preparation of 4-(trifluoromethyl)azetidin-2-ones and their synthetic potential as eligible new building blocks for the construction of CF3-containing azetidines, diaminopropanes, aminopropanol derivatives, 1,3-oxazinanes, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e69b7f35dac3b5f4dcc18f10efeb788e
https://doi.org/10.1055/s-0035-1561316
https://doi.org/10.1055/s-0035-1561316
Autor:
Tom Desmet, Matthias D'hooghe, Jens Mincke, Karel De Winter, Bert De Schrijver, Jeroen Bomon, Karen Mollet, Lena Decuyper, Nicola Piens
Publikováno v:
RSC ADVANCES
(3R, 4S)-3-Alkoxy/aryloxy-4-(cyanomethyl) azetidin-2-ones were efficiently prepared from readily available 1,2: 5,6-di-D-isopropylidene-D-mannitol by means of a classical organic synthesis approach via 4-hydroxymethyl-beta-lactams as key intermediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac4e7ea34736c0d558eaec8fb15c38a
https://doi.org/10.1039/c6ra08213k
https://doi.org/10.1039/c6ra08213k
Autor:
Tuyet Anh Dang Thi, Yves Depetter, Karen Mollet, Hoang Thi Phuong, Doan Vu Ngoc, Chinh Pham The, Ha Thanh Nguyen, Thu Ha Nguyen Thi, Hung Huy Nguyen, Matthias D’hooghe, Tuyen Van Nguyen
Publikováno v:
TETRAHEDRON LETTERS
Heterocyclic naphthoquinones represent valuable scaffolds in medicinal chemistry. In the present Letter, the efficient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones by means of one-pot multicomponent reactions using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a6dc2254de8f7b3252f7880058c670
https://doi.org/10.1016/j.tetlet.2015.03.071
https://doi.org/10.1016/j.tetlet.2015.03.071
Publikováno v:
MINI-REVIEWS IN ORGANIC CHEMISTRY
Azaheterocycles comprise relevant target structures within organic chemistry due to the broad diversity of biological activities associated with these scaffolds. In this review, the most important recent procedures for the preparation of functionaliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5debcc072e2d4db75ce669a2b072ec49
https://doi.org/10.2174/1570193x11310010001
https://doi.org/10.2174/1570193x11310010001
Autor:
Tom Desmet, Matthias D'hooghe, Leen Broeckx, Norbert De Kimpe, Karen Mollet, Barbara Danneels
Publikováno v:
TETRAHEDRON
cis-2-(2-Bromo-1,1-dimethylethyl)azetidines were transformed into novel 5,5-dimethylpiperidin-4-ones through a ring expansion–oxidation protocol upon heating in DMSO in the presence of Ag2CO3 or AgBF4. In addition, several 5,5-nor-dimethyl analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a62c807caa7d8b586fa7da3a2e7487
https://doi.org/10.1016/j.tet.2013.01.045
https://doi.org/10.1016/j.tet.2013.01.045
Autor:
Hannelore Goossens, Veronique Van Speybroeck, Saron Catak, Norbert De Kimpe, Matthias D'hooghe, Karl W. Törnroos, Michel Waroquier, Nicola Piens, Karen Mollet
Publikováno v:
Chemistry – A European Journal. 19:3383-3396
The reactivity of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams with regard to the oxidant sodium periodate was evaluated, unexpectedly resulting in the exclusive formation of new 2-hydroxy-1,4-oxazin-3-ones through a C3C4 bond cleavage of the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6942c99b0ef8327e9a7af22d2941f868
https://doi.org/10.1002/chem.201203314
https://doi.org/10.1002/chem.201203314
Publikováno v:
Tetrahedron. 68:10787-10793
cis-3-Benzyloxy-4-(2-mesyloxyethyl)azetidin-2-ones were shown to be useful starting products for the synthesis of cis-2-oxa-6-azabicyclo[3.2.0]heptan-7-ones in high overall yields and purity upon hydrogenolysis of the benzyl ether substituent followe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47f3dca0244bbb89c5d6aa6aa942399
https://doi.org/10.1016/j.tet.2012.01.001
https://doi.org/10.1016/j.tet.2012.01.001
Autor:
Jorick Franceus, Sven De Craene, Karen Mollet, Tom Desmet, Nicola Piens, Matthias D'hooghe, Kristof Van Hecke
Publikováno v:
ORGANIC & BIOMOLECULAR CHEMISTRY
cis-3-Acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones were prepared through a Staudinger [2+2]-cyclo-condensation between acetoxyketene and the appropriate epoxyimines in a highly diastereoselective way. Subsequent potassium carbonate-mediated acetate h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6555aad34dd67ea17cb2aeb56a9707
https://pubmed.ncbi.nlm.nih.gov/27853806
https://pubmed.ncbi.nlm.nih.gov/27853806