Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Karen Meaburn"'
Autor:
Michalis Amoiridis, John Verigos, Karen Meaburn, William H. Gittens, Tao Ye, Matthew J. Neale, Evi Soutoglou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract DNA replication and transcription generate DNA supercoiling, which can cause topological stress and intertwining of daughter chromatin fibers, posing challenges to the completion of DNA replication and chromosome segregation. Type II topoiso
Externí odkaz:
https://doaj.org/article/d7622845b0994768a17aea775ae7a74d
Autor:
Karen Meaburn
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
In eukaryotic cells the genome is highly spatially organized. Functional relevance of higher order genome organization is implied by the fact that specific genes, and even whole chromosomes, alter spatial position in concert with functional changes w
Externí odkaz:
https://doaj.org/article/5b8265d3808047a29702c934c660152d
Autor:
Angeliki Platania, Cathie Erb, Mariano Barbieri, Bastien Molcrette, Erwan Grandgirard, Marit AC de Kort, Karen Meaburn, Tiegh Taylor, Virlana M Shchuka, Silvia Kocanova, Guilherme Monteiro Oliveira, Jennifer A Mitchell, Evi Soutoglou, Tineke L Lenstra, Nacho Molina, Argyris Papantonis, Kerstin Bystricky, Tom Sexton
SUMMARYThe spatiotemporal configuration of genes with distal regulatory elements, and the impact of chromatin mobility on transcription, remain unclear. Loop extrusion is an attractive model for bringing genetic elements together, but how this functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d54da95b9476e7cf0d9e77f302b60e3
https://doi.org/10.2139/ssrn.4428770
https://doi.org/10.2139/ssrn.4428770
Autor:
Bernardo Reina-San-Martin, Karen Meaburn, Duygu Yilmaz, Audrey Furst, Evi Soutoglou, Yanlin Wen, Aleksandra Lezaja, Matthias Altmeyer
Publikováno v:
Nature
Nature, 2021, 600, pp.748-753. ⟨10.1038/s41586-021-04200-z⟩
Nature, 2021, 600, pp.748-753. ⟨10.1038/s41586-021-04200-z⟩
Centromeric integrity is key for proper chromosome segregation during cell division1. Centromeres have unique chromatin features that are essential for centromere maintenance2. Although they are intrinsically fragile and represent hotspots for chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f58905d7aa6267213fb94bbb657ed77
https://hal.science/hal-03714790
https://hal.science/hal-03714790