Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Karen Margrethe Engell"'
Autor:
Jakob Felding, Morten Dahl Sørensen, Karen Margrethe Engell, Pontus Hegardt, Jens Christian Højland Larsen, Anne Marie Vinggaard, Anders Søhoel, Pia Refer, Simon Feldbaek Nielsen, Christina Andersson, Lotte G. Ladefoged, Tina Dahlerup Poulsen, Thorsten Thormann
Publikováno v:
Journal of Medicinal Chemistry. 57:5893-5903
Development of orally available phosphodiesterase 4 (PDE4) inhibitors as anti-inflammatory drugs has been going on for decades. However, only roflumilast has received FDA approval. One key challenge has been the low therapeutic window observed in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba6a2198c41f3791da043fbf961f273
https://doi.org/10.1021/jm500378a
https://doi.org/10.1021/jm500378a
Autor:
Malene Bertelsen, Kristoffer Månsson, Thomas Högberg, Anke Soor, Morten Dahl Sørensen, Gunnar Grue-Sørensen, Karen Margrethe Engell, Martin Stahlhut, Per Vedsø, Xifu Liang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:54-60
Ingenol 3-benzoates were investigated with respect to chemical stability, pro-inflammatory effects, cell death induction and PKCδ activation. A correlation between structure, chemical stability and biological activity was found and compared to ingen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef81444b0cd83146f287cf921961615
https://doi.org/10.1016/j.bmcl.2013.11.073
https://doi.org/10.1016/j.bmcl.2013.11.073
Autor:
Karen Margrethe Engell, Karsten Petersson, M. Funch Carlsen, K. Troensegaard Nielsen, John-Olov Jansson, A. Huss Eriksson, P. Kemp, M. Røpke
Publikováno v:
Journal of Investigative Dermatology. 139:S281
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b11e5c1be45e9124b1a6a86e14bea4a
https://doi.org/10.1016/j.jid.2019.07.389
https://doi.org/10.1016/j.jid.2019.07.389
Autor:
Karen Margrethe Engell, Kristoffer Månsson, Martin Stahlhut, Malene Bertelsen, Xifu Liang, Gunnar Grue-Sørensen, Thomas Högberg, Anke Soor, Per Vedsø
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5624-5629
Ingenol mebutate is the active ingredient in Picato® a new drug for the treatment of actinic keratosis. A number of derivatives related to ingenol mebutate were prepared by chemical synthesis from ingenol with the purpose of investigating the SAR an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4814b15cfc33582ab52f7a126e884fb7
https://doi.org/10.1016/j.bmcl.2013.08.038
https://doi.org/10.1016/j.bmcl.2013.08.038