Výsledky vyhledávání - "Karen Maresso"

Genetics, genomics and the power of stem cells to identify novel treatment options in complex diseases

Publikováno v: Personalized Medicine. 9:821-828

The advances in human genetics enabled through the implementation of the latest sequencing technologies have the potential to dramatically change the landscape of medicine. As we decipher the polymorphic structure of the genome, the next challenge wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ddc5768d3c6ab22bb49935ea77a1ef
https://doi.org/10.2217/pme.12.92

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IL6 gene-wide haplotype is associated with susceptibility to acute lung injury

Autor: Michael S. Wade, Carlos Flores, Shwu Fan Ma, Joe G.N. Garcia, Karen Maresso, Jesús Villar

Publikováno v: Translational Research. 152:11-17

Experimental and clinical studies support the key role of interleukin 6 (IL-6), a potent proinflammatory cytokine, in the development of acute lung injury (ALI). Plasma IL-6 levels are influenced mainly by genetic determinants, and a −174G/C polymo

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https://doi.org/10.1016/j.trsl.2008.05.006

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Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man

Publikováno v: Journal of Experimental Medicine, 204(8), 1935-1944. ROCKEFELLER UNIV PRESS
The Journal of Experimental Medicine

Liver-derived acute phase proteins (APPs) emerged as powerful predictors of cardiovascular disease and cardiovascular events, but their functional role in atherosclerosis remains enigmatic. We report that the gp130 receptor, which is a key component

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https://doi.org/10.1084/jem.20070120

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A locus on chromosome 10 influences C-reactive protein levels in two independent populations

Autor: Michael D. Harrison, Johanne Tremblay, Christian Glöckner, Jeff T. Williams, Karen Maresso, Ulrich Broeckel, Christian Hengstenberg, Ondrej Seda, Jeanette Erdmann, Howard J. Jacob, Heribert Schunkert, Gerd Schmitz, Bjoern Mayer, Daniel Gaudet, Lisa J. Martin, Stephan R. Holmer, Guenter Riegger, Pavel Hamet

Publikováno v: Human Genetics. 122:95-102

High sensitivity C-reactive protein (hsCRP) is an independent risk factor for cardiovascular disease, such as stroke or coronary artery disease. Genetic factors influence significantly the inter-individual variability of hsCRP. The aim of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f38ea07217b1c4de020df460d164be
https://doi.org/10.1007/s00439-007-0380-9

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A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans

Autor: Shwu Fan Ma, Carlos Flores, Carole Ober, Joe G.N. Garcia, Karen Maresso

Publikováno v: Genetic Epidemiology. 31:296-305

Asthma is a complex phenotype influenced by environmental and genetic factors for which severe irreversible structural airway alterations are more frequently observed in African Americans. In addition to a multitude of factors contributing to its pat

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https://doi.org/10.1002/gepi.20210

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Functional Genomics and Its Implications for Molecular Medicine

Autor: Ulrich Broeckel, Karen Maresso, Subra Kugathasan

Publikováno v: Pediatric Clinics of North America. 53:807-816

Technological development in genetics and genomics provides unprecedented possibilities to identify the underlying molecular basis of many common diseases. With the availability of the human genome sequence and growing information on the most frequen

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https://doi.org/10.1016/j.pcl.2006.08.007

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Genomics of Acute Lung Injury

Autor: Carlos Flores, Shwu Fan Ma, Joe G.N. Garcia, Omer Ahmed, Karen Maresso

Publikováno v: Seminars in Respiratory and Critical Care Medicine. 27:389-395

Acute lung injury (ALI) is a complex syndrome involving the interplay of both environmental (such as the addition of mechanical ventilation) and genetic factors. Clinical models have identified risk factors for development and poor outcome but these

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https://doi.org/10.1055/s-2006-948292

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CARD15 gene mutations and risk for early surgery in pediatric-onset Crohn’s disease

Autor: Colin D. Rudolph, Subra Kugathasan, Raymond G. Hoffmann, Karen Maresso, Ulrich Broeckel, Steven L. Werlin, Nicole Collins, Michael C. Stephens

Publikováno v: Clinical Gastroenterology and Hepatology. 2:1003-1009

The risk for Crohn's disease (CD) is determined in part by genetic factors. Three recently described mutations in the CARD15(NOD2) gene have been associated with adult-onset CD. We investigated the effect of CARD15 mutations on disease manifestation,

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https://doi.org/10.1016/s1542-3565(04)00452-5

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The role of genomics in the neonatal ICU

Autor: Karen Maresso, Ulrich Broeckel

Publikováno v: Clinics in perinatology. 36(1)

Results of both the Human Genome and International HapMap Projects have provided the technology and resources necessary to enable fundamental advances through the study of DNA sequence variation in almost all fields of medicine, including neonatology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2107fc1b0246ce1ecda6c272f498063
https://pubmed.ncbi.nlm.nih.gov/19161875

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