Výsledky vyhledávání - "Karen MacRae"

A Novel Chemokine-Receptor-5 (CCR5) Blocker, SCH532706, Has Differential Effects on CCR5+CD4+and CCR5+CD8+T Cell Numbers in Chronic HIV Infection

Autor: Michelle Bailey, John M. Murray, Sarah Pett, David A. Cooper, Sean Emery, John Zaunders, Karen MacRae, Anthony D. Kelleher

Publikováno v: AIDS Research and Human Retroviruses. 26:653-661

HIV treatment with CCR5 receptor blockers may impact CCR5(+) cell distribution. T cell subsets, plasmacytoid dendritic cells (PDC), and antigen-specific [Mycobacteria tuberculosis/avium (M.TB/MAI), cytomegalovirus (CMV), Herpes simplex (HSV), HIV-Gag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65b155104ccaf082a6003f11d6744f8
https://doi.org/10.1089/aid.2009.0278

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A Phase I study to explore the activity and safety of SCH532706, a small molecule chemokine receptor-5 antagonist in HIV type-1-infected patients

Autor: Sarah Pett, Karen MacRae, Julie M. Strizki, Richard Norris, Sean Emery, Amol Tendolkar, Kenneth M. Williams, Michael McCarthy, David A. Cooper

Publikováno v: Antiviral Therapy. 14:111-115

Background SCH532706 is a novel small molecule chemokine receptor-5 (CCR5) antagonist with high in vitro potency (mean 90% inhibitory concentration [IC90] 0.15– 7.0 nM) against diverse HIV type-1 (HIV-1) isolates. Methods A single arm study was und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1d43f2484d4668fc31cc0a0b44b9416
https://doi.org/10.1177/135965350901400112

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The Safety, Efficacy, and Pharmacokinetic Profile of a Switch in Antiretroviral Therapy to Saquinavir, Ritonavir, and Atazanavir Alone for 48 Weeks and a Switch in the Saquinavir Formulation

Autor: Alan Winston, Sean Emery, Kenneth M. Williams, Malte Schutz, Matthew Law, Karen MacRae, David A. Cooper, Claudette S. Satchell, Patrick W. G. Mallon

Publikováno v: Clinical Infectious Diseases. 44:1475-1483

Background. Toxicities observed with current combination antiretroviral therapy (CART) warrant a search for novel options, such as class-sparing regimens. Ritonavir-boosted double-protease inhibitor (PI)-only regimens are such an option but are prone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510227195ed046f3c1f60a80659a6ba5
https://doi.org/10.1086/517507

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A randomized study of pharmacokinetics, efficacy, and safety of 2 raltegravir plus atazanavir strategies in ART-treated adults

Autor: Mark Bloch, David A. Cooper, Sarah Pett, John E. Ray, Sean Emery, Handan Wand, Dianne Carey, Kate Beileiter, Karen MacRae, Mark A. Boyd

Publikováno v: Journal of acquired immune deficiency syndromes (1999). 60(2)

Background: New antiretroviral drug classes provide opportunities to explore novel regimens. Methods: HIV+ adults (l50 copies/mL) receiving atazanavir (ATV) were randomized to raltegravir (RAL) 400 mg + ATV 300 mg twice daily (q12h) for 4 weeks follo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9bb12653f1553fbc914d549fa3f038
https://pubmed.ncbi.nlm.nih.gov/22421745

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A phase I study to explore the activity and safety of SCH532706, a small molecule chemokine receptor-5 antagonist in HIV type-1-infected patients

Autor: Sarah L, Pett, Michael C, McCarthy, David A, Cooper, Karen, MacRae, Amol, Tendolkar, Richard, Norris, Julie M, Strizki, Kenneth M, Williams, Sean, Emery

Publikováno v: Antiviral therapy. 14(1)

SCH532706 is a novel small molecule chemokine receptor-5 (CCRS) antagonist with high in vitro potency (mean 90% inhibitory concentration [IC90] 0.15-7.0 nM) against diverse HIV type-1 (HIV-1) isolates.A single arm study was undertaken to examine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87d55b02c50354940f9862e7bf9f1cdf
https://pubmed.ncbi.nlm.nih.gov/19320244

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Home chemotherapy: NHS and independent sector collaboration

Autor: John, Pattison, Karen, MacRae

Publikováno v: Nursing times. 98(35)

Current government health policy calls for increased collaboration between acute and primary care, and between the NHS and the independent sector. This article describes an initiative in which an NHS trust contracted an independent company to provide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00d1d65241cc60c0efe67a1140be7f61
https://pubmed.ncbi.nlm.nih.gov/12224498

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