Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Karen M. Wassarman"'
Autor:
Jeanette R. Comstock, Laura S. Hall, Karen M. Wassarman, Amanda J. Brinkworth, D. Scott Samuels, Dan Drecktrah
Publikováno v:
Mol Microbiol
6S RNA binds to RNA polymerase and regulates gene expression, contributing to bacterial adaptation to environmental stresses. In this study, we examined the role of 6S RNA in murine infectivity and tick persistence of the Lyme disease spirochete Borr
Autor:
Karen M. Wassarman
Publikováno v:
Microbiology Spectrum. 6
6S RNA is a small RNA regulator of RNA polymerase (RNAP) that is present broadly throughout the bacterial kingdom. Initial functional studies in Escherichia coli revealed that 6S RNA forms a complex with RNAP resulting in regulation of transcription,
Autor:
Ami Yamamoto, Tobias Bender, Amy K. Klimowicz, Joseph P. Dillard, Melanie M. Callaghan, Meghan E. Ramsey, Kathleen T. Hackett, Chris van der Does, Karen M. Wassarman, Adrienne S Jolicoeur
Publikováno v:
Molecular Microbiology. 97:1168-1185
Gonococci secrete chromosomal DNA into the extracellular environment using a type IV secretion system (T4SS). The secreted DNA acts in natural transformation and initiates biofilm development. Although the DNA and its effects are detectable, structur
Autor:
Katherine Leon, Karen M. Wassarman, Thomas Walz, Jared T. Winkelman, Zongli Li, Shili Feng, Andrey Feklistov, Seth A. Darst, James Chen, Elizabeth A. Campbell
Publikováno v:
Molecular cell. 68(2)
Summary Noncoding RNAs (ncRNAs) regulate gene expression in all organisms. Bacterial 6S RNAs globally regulate transcription by binding RNA polymerase (RNAP) holoenzyme and competing with promoter DNA. Escherichia coli ( Eco ) 6S RNA interacts specif
Publikováno v:
Nucleic Acids Research
The 6S RNA is a non-coding small RNA that binds within the active site of housekeeping forms of RNA polymerases (e.g. Eσ(70) in Escherichia coli, Eσ(A) in Bacillus subtilis) and regulates transcription. Efficient release of RNA polymerase from 6S R
Autor:
Karen M. Wassarman, Amy T. Cavanagh
Publikováno v:
Journal of Bacteriology. 195:2079-2086
We have discovered that 6S-1 RNA (encoded by bsrA ) is important for appropriate timing of sporulation in Bacillus subtilis in that cells lacking 6S-1 RNA sporulate earlier than wild-type cells. The time to generate a mature spore once the decision t
Publikováno v:
Nucleic Acids Research
6S RNAs function through interaction with housekeeping forms of RNA polymerase holoenzyme (Eσ(70) in Escherichia coli, Eσ(A) in Bacillus subtilis). Escherichia coli 6S RNA accumulates to high levels during stationary phase, and has been shown to be
Publikováno v:
Molecular Cell. 43:880-891
Research on the discovery and characterization of small, regulatory RNAs in bacteria has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein a
Autor:
Karen M. Wassarman, Andrew D. Klocko
Publikováno v:
Molecular Microbiology. 73:152-164
6S RNA is a small, noncoding RNA that interacts with σ70-RNA polymerase and down-regulates transcription at many promoters during stationary phase. When bound to σ70-RNA polymerase, 6S RNA is engaged in the active site of σ70-RNA polymerase in a m
Publikováno v:
Molecular Microbiology. 67:1242-1256
6S RNA binds sigma70-RNA polymerase and downregulates transcription at many sigma70-dependent promoters, but others escape regulation even during stationary phase when the majority of the transcription machinery is bound by the RNA. We report that co