Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karen M. Wagner"'
Autor:
William K. Schmidt, Irene Cortés‐Puch, Cindy B. McReynolds, Glenn E. Croston, Sung Hee Hwang, Jun Yang, Theresa L. Pedersen, Karen M. Wagner, Theresa T. Pham, Thomas Hunt, Bruce D. Hammock
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 9, Pp n/a-n/a (2024)
Abstract Chronic pain represents a significant unmet medical need, affecting one‐fifth of the U.S. population. EC5026 is a small molecule inhibitor of the enzyme soluble epoxide hydrolase (sEH) which is being developed as a novel non‐opioid, non
Externí odkaz:
https://doaj.org/article/d23ba464802241f69df3a0fdd283dc0d
Publikováno v:
Frontiers in Pain Research, Vol 3 (2023)
Chemotherapy induced peripheral neuropathy (CIPN) is a particularly pernicious form of neuropathy and the associated pain is the primary dose-limiting factor of life-prolonging chemotherapy treatment. The prevalence of CIPN is high and can last long
Externí odkaz:
https://doaj.org/article/06dc6ce99eea4af691e907cd9c1376d2
Autor:
Weicang Wang, Yuxin Wang, Jun Yang, Karen M. Wagner, Sung Hee Hwang, Jeff Cheng, Nalin Singh, Patricia Edwards, Christophe Morisseau, Guodong Zhang, Dipak Panigrahy, Bruce D. Hammock
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 249, Iss , Pp 114417- (2023)
Aflatoxin B1 (AFB1) contamination in food and feed leads to severe global health problems. Acting as the frontier immunological barrier, the intestinal mucosa is constantly challenged by exposure to foodborne toxins such as AFB1 via contaminated diet
Externí odkaz:
https://doaj.org/article/b86630bc862b4620bcd224329a2856c0
Autor:
Weicang Wang, Yuxin Wang, Karen M. Wagner, Ruth Diana Lee, Sung Hee Hwang, Christophe Morisseau, Heike Wulff, Bruce D. Hammock
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9938 (2023)
Parkinson’s disease (PD) is an increasingly common neurodegenerative movement disorder with contributing factors that are still largely unexplored and currently no effective intervention strategy. Epidemiological and pre-clinical studies support th
Externí odkaz:
https://doaj.org/article/9080de19c6f14fafb0d884cab702baf4
Autor:
Nalin Singh, Bogdan Barnych, Karen M. Wagner, Debin Wan, Christophe Morisseau, Bruce D. Hammock
Publikováno v:
ACS Omega, Vol 6, Iss 10, Pp 7165-7174 (2021)
Externí odkaz:
https://doaj.org/article/b0aca19c8d4f4d049c2866fd755c81e9
Autor:
Weicang Wang, Karen M. Wagner, Yuxin Wang, Nalin Singh, Jun Yang, Qiyi He, Christophe Morisseau, Bruce D. Hammock
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4570 (2023)
Aging, which is characterized by enhanced cell senescence and functional decline of tissues, is a major risk factor for many chronic diseases. Accumulating evidence shows that age-related dysfunction in the colon leads to disorders in multiple organs
Externí odkaz:
https://doaj.org/article/afcb9d1b3a4248e7820fc42189a44435
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The soluble epoxide hydrolase (sEH) enzyme is a major regulator of bioactive lipids. The enzyme is highly expressed in liver and kidney and modulates levels of endogenous epoxy-fatty acids, which have pleiotropic biological effects including limiting
Externí odkaz:
https://doaj.org/article/edd94037065d490abc5208e2d5314a42
Autor:
Kin Sing Stephen Lee, Jun Yang, Jun Niu, Connie J. Ng, Karen M. Wagner, Hua Dong, Sean D. Kodani, Debin Wan, Christophe Morisseau, Bruce D. Hammock
Publikováno v:
ACS Central Science, Vol 5, Iss 9, Pp 1614-1624 (2019)
Externí odkaz:
https://doaj.org/article/3f4796cb429541709e26a38063e81b17
Autor:
Sean D. Kodani, Debin Wan, Karen M. Wagner, Sung Hee Hwang, Christophe Morisseau, Bruce D. Hammock
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 14076-14086 (2018)
Externí odkaz:
https://doaj.org/article/6196d7777817405f892bcdab38ab5bf3
Autor:
Debin Wan, Jun Yang, Cindy B. McReynolds, Bogdan Barnych, Karen M. Wagner, Christophe Morisseau, Sung Hee Hwang, Jia Sun, René Blöcher, Bruce D. Hammock
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (TPPU) is a potent soluble epoxide hydrolase (sEH) inhibitor that is used extensively in research for modulating inflammation and protecting against hypertension, neuropathic pain, and
Externí odkaz:
https://doaj.org/article/2f30d7a9295949dcb6cb5a6cf888b247