Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Karen M. O'Shea"'
Autor:
Karen M. O'Shea, Radha Ananthakrishnan, Qing Li, Nosirudeen Quadri, Devi Thiagarajan, Gopalkrishna Sreejit, Lingjie Wang, Hylde Zirpoli, Juan Francisco Aranda, Arthur S. Alberts, Ann Marie Schmidt, Ravichandran Ramasamy
Publikováno v:
EBioMedicine, Vol 26, Iss C, Pp 165-174 (2017)
The biochemical, ionic, and signaling changes that occur within cardiomyocytes subjected to ischemia are exacerbated by reperfusion; however, the precise mechanisms mediating myocardial ischemia/reperfusion (I/R) injury have not been fully elucidated
Externí odkaz:
https://doaj.org/article/a4833b9b626f400b8610176c912adfc6
Autor:
Devi Thiagarajan, Radha Ananthakrishnan, Jinghua Zhang, Karen M. O’Shea, Nosirudeen Quadri, Qing Li, Kelli Sas, Xiao Jing, Rosa Rosario, Subramaniam Pennathur, Ann Marie Schmidt, Ravichandran Ramasamy
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 181-196 (2016)
Histone deacetylase 3 (HDAC3), a chromatin-modifying enzyme, requires association with the deacetylase-containing domain (DAD) of the nuclear receptor corepressors NCOR1 and SMRT for its stability and activity. Here, we show that aldose reductase (AR
Externí odkaz:
https://doaj.org/article/8bc77572507b48e6bb6d011a73ad36ea
Radical Roles for RAGE in the Pathogenesis of Oxidative Stress in Cardiovascular Diseases and Beyond
Autor:
Radha Ananthakrishnan, Ravichandran Ramasamy, Karen M. O'Shea, Carmen Hurtado del Pozo, Gurdip Daffu, Ann Marie Schmidt
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19891-19910 (2013)
Oxidative stress is a central mechanism by which the receptor for advanced glycation endproducts (RAGE) mediates its pathological effects. Multiple experimental inquiries in RAGE-expressing cultured cells have demonstrated that ligand-RAGE interactio
Externí odkaz:
https://doaj.org/article/59ab2a253c614e9d852c5932cb767bfa
Autor:
Kristen L. King, Martin E. Young, Janos Kerner, Hazel Huang, Karen M. O'Shea, Stefan E.H. Alexson, Charles L. Hoppel, William C. Stanley
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 7, Pp 1511-1517 (2007)
Peroxisome proliferator-activated receptor α (PPARα) is a transcriptional regulator of the expression of mitochondrial thioesterase I (MTE-I) and uncoupling protein 3 (UCP3), which are induced in the heart at the mRNA level in response to diabetes.
Externí odkaz:
https://doaj.org/article/7f9c757c21214778a1ae087133aa4bc3
Autor:
Karen S. Chen, Kelly Howell, Shaun M. Cote, Karen M. O'Shea, Joseph P. Stains, Sergey Paushkin, Adriana Donovan, Erin Renae Treece, Ramzi J. Khairallah, Alan Buckler, Long Kimberly, Micah T. Webster
Publikováno v:
Human Molecular Genetics
Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of α-motor neurons, leading to profound skeletal muscle atrophy. Patients also suffer from decreased bone mineral density and increased fracture risk. The majority of tre
Autor:
Ramzi J Khairallah, Junhwan Kim, Karen M O'Shea, Kelly A O'Connell, Bethany H Brown, Tatiana Galvao, Caroline Daneault, Christine Des Rosiers, Brian M Polster, Charles L Hoppel, William C Stanley
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34402 (2012)
Mitochondria can depolarize and trigger cell death through the opening of the mitochondrial permeability transition pore (MPTP). We recently showed that an increase in the long chain n3 polyunsaturated fatty acids (PUFA) docosahexaenoic acid (DHA; 22
Externí odkaz:
https://doaj.org/article/1fe31664e72946438d1b8563049d6a60
Autor:
Devi Thiagarajan, Nosirudeen Quadri, Lingjie Wang, Radha Ananthakrishnan, Ravichandran Ramasamy, Juan F. Aranda, Arthur S. Alberts, Gopalkrishna Sreejit, Qing Li, Karen M. O'Shea, Ann Marie Schmidt, Hylde Zirpoli
Publikováno v:
EBioMedicine, Vol 26, Iss C, Pp 165-174 (2017)
EBioMedicine
EBioMedicine
The biochemical, ionic, and signaling changes that occur within cardiomyocytes subjected to ischemia are exacerbated by reperfusion; however, the precise mechanisms mediating myocardial ischemia/reperfusion (I/R) injury have not been fully elucidated
Publikováno v:
Mechanisms Linking Aging, Diseases and Biological Age Estimation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b6c7b553210eef1f0e2694fe01d385
https://doi.org/10.1201/9781315371382-10
https://doi.org/10.1201/9781315371382-10
Radical Roles for RAGE in the Pathogenesis of Oxidative Stress in Cardiovascular Diseases and Beyond
Autor:
Ravichandran Ramasamy, Ann Marie Schmidt, Karen M. O'Shea, Carmen Hurtado del Pozo, Radha Ananthakrishnan, Gurdip Daffu
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19891-19910 (2013)
International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19891-19910 (2013)
Oxidative stress is a central mechanism by which the receptor for advanced glycation endproducts (RAGE) mediates its pathological effects. Multiple experimental inquiries in RAGE-expressing cultured cells have demonstrated that ligand-RAGE interactio
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:2068-2076
Insulin resistance is a characteristic feature of obesity and type 2 diabetes mellitus and impacts the heart in various ways. Impaired insulin-mediated glucose uptake is a uniformly observed characteristic of the heart in these states, although chang