Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Karen M. O'Connor"'
Autor:
Karen M. O'Connor, Eric F. Lucking, Anna V. Golubeva, Conall R. Strain, Fiona Fouhy, María C. Cenit, Pardeep Dhaliwal, Thomaz F.S. Bastiaanssen, David P. Burns, Catherine Stanton, Gerard Clarke, John F. Cryan, Ken D. O'Halloran
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 618-638 (2019)
Background: It is increasingly evident that perturbations to the diversity and composition of the gut microbiota have significant consequences for the regulation of integrative physiological systems. There is growing interest in the potential contrib
Externí odkaz:
https://doaj.org/article/237e1bac30724bebbfeb0f86fa6ed731
Autor:
Karen M. O'Connor, Eric F. Lucking, Thomaz F.S. Bastiaanssen, Veronica L. Peterson, Fiona Crispie, Paul D. Cotter, Gerard Clarke, John F. Cryan, Ken D. O'Halloran
Publikováno v:
EBioMedicine, Vol 59, Iss , Pp 102968- (2020)
Background: Evidence is accruing to suggest that microbiota-gut-brain signalling plays a regulatory role in cardiorespiratory physiology. Chronic intermittent hypoxia (CIH), modelling human sleep apnoea, affects gut microbiota composition and elicits
Externí odkaz:
https://doaj.org/article/2de41414f2b3401688ed4a853a6a3af1
Autor:
Eric F. Lucking, Karen M. O'Connor, Conall R. Strain, Fiona Fouhy, Thomaz F.S. Bastiaanssen, David P. Burns, Anna V. Golubeva, Catherine Stanton, Gerard Clarke, John F. Cryan, Ken D. O'Halloran
Publikováno v:
EBioMedicine, Vol 38, Iss , Pp 191-205 (2018)
Background: Carotid body (peripheral oxygen sensor) sensitisation is pivotal in the development of chronic intermittent hypoxia (CIH)-induced hypertension. We sought to determine if exposure to CIH, modelling human sleep apnoea, adversely affects car
Externí odkaz:
https://doaj.org/article/781ffd88caf446ceac530de6f98e2a59
Autor:
Maria L. Dias, Golnar Eftekhari, Karen M. O'Connor, Eugene M. Dempsey, Ken D. O'Halloran, Fiona B. McDonald
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ff8009d6c03b910876182d3f3b187bb
https://doi.org/10.1096/fasebj.2022.36.s1.r5911
https://doi.org/10.1096/fasebj.2022.36.s1.r5911
Autor:
Karen M. O'Connor, Owen I. Corrigan
Publikováno v:
International Journal of Pharmaceutics. 222:281-293
Non steroidal anti-inflammatory agents (NSAIDs) such as diclofenac have very low aqueous solubilities and consequently salt formation may be used to enhance solubility and dissolution rate. In this study, we examined the physicochemical properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e50d93350618cf7b949e30766e9b2c
https://doi.org/10.1016/s0378-5173(01)00717-7
https://doi.org/10.1016/s0378-5173(01)00717-7
Autor:
Karen M. O'Connor, Owen I. Corrigan
Publikováno v:
Journal of pharmaceutical sciences. 91(10)
Dissolution of diclofenac from compressed discs containing mixtures of a diclofenac salt and a basic excipient, in various w/w ratios, was examined. Two diclofenac salts, diclofenac deanol (DDNL) and diclofenac tert ‐butylamine, and the basic excip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538f5aec13def138671ee646d901a722
https://pubmed.ncbi.nlm.nih.gov/12226854
https://pubmed.ncbi.nlm.nih.gov/12226854
Autor:
Owen I. Corrigan, Karen M. O'Connor
Publikováno v:
International journal of pharmaceutics. 226(1-2)
Physicochemical properties of diclofenac salts prepared using eight different counterions and including five novel salts, obtained with the bases 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methylpropanol, tert-butylamine, benzylamine and deanol, wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e549bc682d39f342e06dbf608a3cb9
https://pubmed.ncbi.nlm.nih.gov/11532579
https://pubmed.ncbi.nlm.nih.gov/11532579