Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Karen M. Neilson"'
Autor:
Karyn Jourdeuil, Karen M. Neilson, Helene Cousin, Andre L. P. Tavares, Himani D. Majumdar, Dominique Alfandari, Sally A. Moody
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: The Six1 transcription factor plays important roles in the development of cranial sensory organs, and point mutations underlie craniofacial birth defects. Because Six1’s transcriptional activity can be modulated by interacting protein
Externí odkaz:
https://doaj.org/article/104114d54fb74f9685f062e1854349bc
Autor:
Ankita M. Shah, Patrick Krohn, Aparna B. Baxi, Andre L. P. Tavares, Charles H. Sullivan, Yeshwant R. Chillakuru, Himani D. Majumdar, Karen M. Neilson, Sally A. Moody
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Single-nucleotide mutations in human SIX1 result in amino acid substitutions in either the protein-protein interaction domain or the homeodomain, and cause ∼4% of branchio-otic (BOS) and branchio-oto-renal (BOR) cases. The phenotypic variation betw
Externí odkaz:
https://doaj.org/article/48e070aa78a04f5b80328272ae224f6b
Autor:
Steven L. Klein, Karen M. Neilson, John Orban, Sergey Yaklichkin, Jennifer Hoffbauer, Kathy Mood, Ira O. Daar, Sally A. Moody
Publikováno v:
PLoS ONE, Vol 8, Iss 4 (2013)
Externí odkaz:
https://doaj.org/article/f76daee9fd35404a828154dd4be496ab
Autor:
Stephanie Keer, Helene Cousin, Karyn Jourdeuil, Karen M. Neilson, Andre L.P. Tavares, Dominique Alfandari, Sally A. Moody
Publikováno v:
Developmental Biology. 489:62-75
Mcrs1 is a multifunctional protein that is critical for many cellular processes in a wide range of cell types. Previously, we showed that Mcrs1 binds to the Six1 transcription factor and reduces the ability of the Six1-Eya1 complex to upregulate tran
Publikováno v:
Development
Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, and craniofacial and/or renal defects. Variants in the transcription factor Six1 and its co-factor Eya1, both of which are required for otic development, are linked to BOR
Publikováno v:
The FASEB Journal. 35
Autor:
Karen M. Neilson, Himani Datta Majumdar, Sally A. Moody, Karyn Jourdeuil, Andre Luiz Pasqua Tavares
Publikováno v:
The FASEB Journal. 35
Autor:
Steven L Klein, Karen M Neilson, John Orban, Sergey Yaklichkin, Jennifer Hoffbauer, Kathy Mood, Ira O Daar, Sally A Moody
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61845 (2013)
FoxD4L1 is a forkhead transcription factor that expands the neural ectoderm by down-regulating genes that promote the onset of neural differentiation and up-regulating genes that maintain proliferative neural precursors in an immature state. We previ
Externí odkaz:
https://doaj.org/article/2be14c34d873422aa92afb6a5f471c37
Autor:
Kristy L. Kenyon, Sally A. Moody, Karen M. Neilson, Stephanie Keer, Himani D. Majumdar, Nicole Bousquet, Dominique Alfandari, Olivia Macrorie
Publikováno v:
Dev Biol
The Six1 transcription factor plays a major role in craniofacial development. Mutations in SIX1 and its co-factor, EYA1, are causative for about 50% of Branchio-otic/Branchio-oto-renal syndrome (BOR) patients, who are characterized by variable cranio
Autor:
Andre L. P. Tavares, Karen M. Neilson, Aparna Baxi, Charles H. Sullivan, Patrick Krohn, Ankita Shah, Himani D. Majumdar, Sally A. Moody, Yeshwant Chillakuru
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 3 (2020)
Disease Models & Mechanisms
Disease Models & Mechanisms
Single-nucleotide mutations in human SIX1 result in amino acid substitutions in either the protein-protein interaction domain or the homeodomain, and cause ∼4% of branchio-otic (BOS) and branchio-oto-renal (BOR) cases. The phenotypic variation betw