Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karen M. Hite"'
Autor:
Vaibhav Saini, Curtis D. Hose, Anne Monks, Kunio Nagashima, Bingnan Han, Dianne L. Newton, Angelena Millione, Jalpa Shah, Melinda G. Hollingshead, Karen M. Hite, Mark W. Burkett, Rene M. Delosh, Thomas E. Silvers, Dominic A. Scudiero, Robert H. Shoemaker
Publikováno v:
PLoS ONE, Vol 7, Iss 11 (2012)
Externí odkaz:
https://doaj.org/article/2142ceb4717b4b8aaeb8f9465baa7b4e
Autor:
Natalya G. Dulyaninova, Steven C. Almo, Dominic A. Scudiero, Wendy D. Zencheck, Anne R. Bresnick, Karen M. Hite, Robert H. Shoemaker
Publikováno v:
Biochemistry. 50:7218-7227
Overexpression of S100A4, a member of the S100 family of Ca(2+)-binding proteins, is associated with a number of human pathologies, including fibrosis, inflammatory disorders, and metastatic disease. The identification of small molecules that disrupt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26a3c80d24f4d56a211f48d645ef85b
https://doi.org/10.1021/bi200853y
https://doi.org/10.1021/bi200853y
Autor:
William A. Denny, Badarch Uranchimeg, Andrew G. Stephen, Annamaria Rapisarda, Giovanni Melillo, Robert H. Shoemaker, Mark Creighton-Gutteridge, John H. Cardellina, Karen M. Hite
Publikováno v:
Clinical Cancer Research. 13:1010-1018
Purpose: The discovery and development of small-molecule inhibitors of hypoxia-inducible factor-1 (HIF-1) is an attractive, yet challenging, strategy for the development of new cancer therapeutic agents. Here, we report on a novel tricyclic carboxami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d58d4219c659d6fc24c50f9b696790d
https://doi.org/10.1158/1078-0432.ccr-06-2301
https://doi.org/10.1158/1078-0432.ccr-06-2301
Autor:
F Siegel, Wolfgang Walther, Robert H. Shoemaker, Peter M. Schlag, Dominic A. Scudiero, Ulrike Stein, Janice Smith, C. Fleuter, Karen M. Hite, A Kopacek
Publikováno v:
British Journal of Cancer
Background: Colorectal cancers are often chemoresistant toward antitumour drugs that are substrates for ABCB1-mediated multidrug resistance (MDR). Activation of the Wnt/β-catenin pathway is frequently observed in colorectal cancers. This study inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bbf42cef20ebfcd3454e6877edfb11
https://pubmed.ncbi.nlm.nih.gov/22460269
https://pubmed.ncbi.nlm.nih.gov/22460269
Autor:
Susan D. Mertins, John E. Niederhuber, Meghan Gowens, Dominic A. Scudiero, Christina H. Stuelten, Karen M. Hite, Robert H. Shoemaker, Melinda G. Hollingshead, Mike Alley, Johanna I. Busch, Mark W. Burkett
Publikováno v:
Stem Cells
Tumor stem cells or cancer initiating cells (CICs) are single tumor cells that can regenerate a tumor or a metastasis. The identification and isolation of CICs remain challenging, and a variety of putative CIC markers have been described. We hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64f408b26e325dcde8f64462da65a43
https://pubmed.ncbi.nlm.nih.gov/20178109
https://pubmed.ncbi.nlm.nih.gov/20178109
Autor:
Dominic A. Scudiero, Vaibhav Saini, Thomas Silvers, Bingnan Han, Jalpa Shah, Melinda G. Hollingshead, Rene Delosh, Robert H. Shoemaker, Angelena Millione, Karen M. Hite, Anne Monks, Curtis Hose, Kunio Nagashima, Mark W. Burkett, Dianne L. Newton
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41401 (2012)
PLoS ONE
PLoS ONE
Recently, there has been renewed interest in the role of tumor stem cells (TSCs) in tumorigenesis, chemoresistance, and relapse of malignant tumors including osteosarcoma. The potential exists to improve osteosarcoma treatment through characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bac6570d60c22842c913389c637175
https://doi.org/10.1371/journal.pone.0041401
https://doi.org/10.1371/journal.pone.0041401
Autor:
Mark W. Burkett, John E. Niederhuber, Robert H. Shoemaker, Susan D. Mertins, Michael C. Alley, Karen M. Hite
Publikováno v:
Cancer Research. 72:3379-3379
Cancer stem cells have been the focus of renewed interest in recent years. In theory these cells have the potential to limit the success of therapy, serving as therapy-resistant reservoirs of disease. In a previous study (Proc AACR 2011 #5202), each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe8773ffc43063453fc78a533b97c01d
https://doi.org/10.1158/1538-7445.am2012-3379
https://doi.org/10.1158/1538-7445.am2012-3379
Autor:
Christina H. Stuelten, Johanna I. Busch, Dominic A. Scudiero, John E. Niederhuber, Karen M. Hite, Melinda G. Hollingshead, Robert H. Shoemaker, Meghan Gowens, Mark W. Burkett, Susan D. Mertins, Michael C. Alley
Publikováno v:
Cancer Research. 70:3372-3372
Tumor stem cells or cancer initiating cells are tumor cells that can regenerate a recurring tumor or a metastasis. A variety of cell surface and other markers have been associated with identification and characterization of tumor stem cells. We inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d270a93b28350ca13eda96b6a17485cc
https://doi.org/10.1158/1538-7445.am10-3372
https://doi.org/10.1158/1538-7445.am10-3372
Autor:
Susan D Mertins, Dominic A Scudiero, Melinda G Hollingshead, Raymond D Divelbiss, Michael C Alley, Anne Monks, David G Covell, Karen M Hite, David S Salomon, John E Niederhuber
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57099 (2013)
BACKGROUND: Cancer stem cells (CSC) are thought to be responsible for tumor maintenance and heterogeneity. Bona fide CSC purified from tumor biopsies are limited in supply and this hampers study of CSC biology. Furthermore, purified stem-like CSC sub
Externí odkaz:
https://doaj.org/article/36d4ba16194044c6a39e47c1292af060
Autor:
Vaibhav Saini, Curtis D Hose, Anne Monks, Kunio Nagashima, Bingnan Han, Dianne L Newton, Angelena Millione, Jalpa Shah, Melinda G Hollingshead, Karen M Hite, Mark W Burkett, Rene M Delosh, Thomas E Silvers, Dominic A Scudiero, Robert H Shoemaker
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41401 (2012)
Recently, there has been renewed interest in the role of tumor stem cells (TSCs) in tumorigenesis, chemoresistance, and relapse of malignant tumors including osteosarcoma. The potential exists to improve osteosarcoma treatment through characterizatio
Externí odkaz:
https://doaj.org/article/4c0c9f3640804c1e875ac9017ea319e6