Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Karen M. Gaudio"'
Autor:
Bettina Bidmon, Gunilla Thulin, Michael Kashgarian, A. S. Mann, Norman J. Siegel, Karen M. Gaudio, Julie Ryu, Kim Reidy, Alfin G. Vicencio
Publikováno v:
Pediatric Nephrology. 18:85-91
The resistance of the immature kidney to ischemic injury is well documented, but the mechanisms involved in this tolerance have been elusive. Previous studies have demonstrated that tubules obtained from immature rats exhibit a bigger stress response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27895259953ff9dd015a313533d3b2fb
https://doi.org/10.1007/s00467-002-1008-x
https://doi.org/10.1007/s00467-002-1008-x
Publikováno v:
American Journal of Physiology-Renal Physiology. 274:F1029-F1036
The stress response was studied in suspensions of tubules from immature (IT) and mature (MT) rats after noninjury, heat, oxygen, and anoxia. Under all conditions, IT exhibited more exuberant activation of heat shock transcription factor (HSF) than MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c8ccc8b40b22f547898db277831cb5
https://doi.org/10.1152/ajprenal.1998.274.6.f1029
https://doi.org/10.1152/ajprenal.1998.274.6.f1029
Publikováno v:
Pediatric Nephrology. 11:757-760
The tolerance of immature tissues to injury has been noted over the past several decades. Traditional teaching relates this tolerance to energy derived from anaerobic glycolysis. This mini-review describes investigations of the hypothesis that the im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700b09dcdd7a3b30cdb063302f53900a
https://doi.org/10.1007/s004670050384
https://doi.org/10.1007/s004670050384
Publikováno v:
Pediatric Research. 40:457-461
We have previously shown that the immature tubule is tolerant of prolonged anoxia. In addition, cellular ATP is maintained at 2-fold higher levels during anoxia in the immature tubules compared with the mature tubules. The purpose of this study was:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a1ebd57c19331dafc35fdcccbc0ace
https://doi.org/10.1203/00006450-199609000-00015
https://doi.org/10.1203/00006450-199609000-00015
Publikováno v:
Pediatric Nephrology. 5:591-596
In order to elucidate the pattern of redistribution of cellular energy and the restoration of basic cellular metabolism following an ischemic renal insult, suspensions enriched in proximal tubule segments were studied after 45 min of bilateral artery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fa890359cda961563cf2c85b948cea
https://doi.org/10.1007/bf00856647
https://doi.org/10.1007/bf00856647
Autor:
Gunilla Thulin, Malcolm J. Avison, Ivy I Boydstun, Xiao Hong Zhu, Karen M. Gaudio, Norman J. Siegel
Publikováno v:
Pediatric Research. 33:595-597
Previous studies from our laboratory have demonstrated that postischemic infusion of thyroxin (T4) will augment the restoration of cellular ATP and enhance the recovery of renal function. It has not been clear, however, whether T4 has a direct effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634361bf0a0f764195993242d238a797
https://doi.org/10.1203/00006450-199306000-00013
https://doi.org/10.1203/00006450-199306000-00013
Autor:
Norman J. Siegel, Robert G. Shulman, Malcolm J. Avison, Karen M. Gaudio, Gunilla Thulin, van Aren Waarde
Publikováno v:
The American journal of physiology. 262(6 Pt 2)
The role of nucleoside uptake in the enhanced metabolic recovery seen with postischemic ATP.MgCl2 was assessed by determining the effect of S-(p-nitrobenzyl)-6-thioinosine (NBTI) on postischemic ATP recovery in rats given normal saline (NS), ATP.MgCl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8674a25c7233b0076fbeaf90298481c
https://pubmed.ncbi.nlm.nih.gov/1621813
https://pubmed.ncbi.nlm.nih.gov/1621813
Publikováno v:
Pediatric Research. 43:308-308
We have previously shown that immature tubules are resistant to anoxia compared to mature tubules. This tolerance is accompanied by an exuberant production of activated heat shock transcription factor. To further assess the role of the stress respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::873c5ebd1d249fe3fade6b453e0b0d96
https://doi.org/10.1203/00006450-199804001-01828
https://doi.org/10.1203/00006450-199804001-01828
Publikováno v:
Pediatric Nephrology. 8:784-784
Very few data are available regarding the decreased susceptibility of the developing kidney to anoxia. Therefore, the purpose of this study was to develop an experimental system that would allow comparison of an anoxic insult in immature and mature p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86f3ca05f04fd2c5a2db915ba1188cd
https://doi.org/10.1007/bf00869125
https://doi.org/10.1007/bf00869125
Autor:
Robert G. Shulman, Norman J. Siegel, M E Stromski, Karen M. Gaudio, van Aren Waarde, Gunilla Thulin, Malcolm J. Avison, Michael Kashgarian
Publikováno v:
Journal of Clinical Investigation. 82:1694-1699
The concentrations of renal ATP have been measured by 31P-nuclear magnetic resonance (NMR) before, during, and after bilateral renal artery occlusion. Using in vivo NMR, the initial postischemic recovery of ATP increased with the magnitude of the res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28257b3f308c17830bac110ee483d572
https://doi.org/10.1172/jci113782
https://doi.org/10.1172/jci113782