Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karen M. Dunkerley"'
Autor:
Karen M. Dunkerley, Anne C. Rintala-Dempsey, Giulia Salzano, Roya Tadayon, Dania Hadi, Kathryn R. Barber, Helen Walden, Gary S. Shaw
The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64719b0fc58557ca38527d14da151290
https://eprints.gla.ac.uk/267568/1/267568.pdf
https://eprints.gla.ac.uk/267568/1/267568.pdf
Autor:
Hadi D, Kathryn R. Barber, Karen M. Dunkerley, Salzano G, Roya Tadayon, Gary S. Shaw, Rintala-Dempsey Ac, Helen Walden
The RBR E3 ligase parkin is recruited to the outer mitochondrial membrane (OMM) during oxidative stress where it becomes activated and ubiquitinates numerous proteins. Parkin activation involves binding of a phosphorylated ubiquitin (pUb), followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9019c1d984b273c0c536de11159a2816
https://doi.org/10.1101/2021.06.01.446590
https://doi.org/10.1101/2021.06.01.446590
Publikováno v:
The Journal of Biological Chemistry
Autosomal recessive juvenile Parkinsonism (ARJP) is an inherited neurodegenerative disease in which 50% of affected individuals harbor mutations in the gene encoding the E3 ligase parkin. Parkin regulates the mitochondrial recycling pathway, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f524786c6dbf532a611bcb4f907815
http://europepmc.org/articles/PMC5925814
http://europepmc.org/articles/PMC5925814
Autor:
Karen M. Dunkerley, Yiming Xiao, Jacob D. Aguirre, Lars Konermann, Helen Walden, Viduth K. Chaugule, Gary S. Shaw, Tara E.C. Condos, Kathryn R. Barber, E. Aisha Freeman
Publikováno v:
The EMBO Journal
The E3 ligase parkin ubiquitinates outer mitochondrial membrane\ud proteins during oxidative stress and is linked to early-onset\ud Parkinson’s disease. Parkin is autoinhibited but is activated by the\ud kinase PINK1 that phosphorylates ubiquitin l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de417e94a46d0eececf520dcfc67da49
https://doi.org/10.15252/embj.2018100014
https://doi.org/10.15252/embj.2018100014
Autor:
Gary S. Shaw, Karen M. Dunkerley
Publikováno v:
Structure(London, England:1993)
Summary RING-between-RING (RBR) E3s contain RING1 domains that are structurally similar yet mechanistically distinct from canonical RING domains. Both types of E3 bind E2∼ubiquitin (E2∼Ub) via their RINGs but canonical RING E3s promote closed E2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba256625676603e009c594b836ca82f
https://pubmed.ncbi.nlm.nih.gov/28552575
https://pubmed.ncbi.nlm.nih.gov/28552575
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(2)
Mutations in PARK2 and PARK6 genes are responsible for the majority of hereditary Parkinson’s disease cases. These genes encode the E3 ubiquitin ligase parkin and the protein kinase PTEN-induced kinase 1 (PINK1), respectively. Together, parkin and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f7b11bef09e6da71ffdf5b65354e65
https://pubmed.ncbi.nlm.nih.gov/28007983
https://pubmed.ncbi.nlm.nih.gov/28007983