Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Karen M. Dobos"'
Autor:
Melissa D. Chengalroyen, Carolina Mehaffy, Megan Lucas, Niel Bauer, Mabule L. Raphela, Nurudeen Oketade, Digby F. Warner, Deborah A. Lewinsohn, David M. Lewinsohn, Karen M. Dobos, Valerie Mizrahi
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 8 (2024)
ABSTRACT Riboflavin (vitamin B2) is the precursor of the flavin coenzymes, FAD and FMN, which play a central role in cellular redox metabolism. While humans must obtain riboflavin from dietary sources, certain microbes, including Mycobacterium tuberc
Externí odkaz:
https://doaj.org/article/9e0d64474c2449c7bd3876da27d5decc
Autor:
Haihong Jin, Nicole A. Ladd, Andrew M. Peev, Gwendolyn M. Swarbrick, Meghan Cansler, Megan Null, Christopher T. Boughter, Curtis McMurtrey, Aaron Nilsen, Karen M. Dobos, William H. Hildebrand, Deborah A. Lewinsohn, Erin J. Adams, David M. Lewinsohn, Melanie J. Harriff
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable inter
Externí odkaz:
https://doaj.org/article/2922d25154b844d9be6d978cad284414
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Tuberculosis (TB) remains a public health issue causing millions of infections every year. Of these, about 15% ultimately result in death. Efforts to control TB include development of new and more effective vaccines, novel and more effective drug tre
Externí odkaz:
https://doaj.org/article/b989d9b56b9b45beb8d4ffc0bd7dd09d
Autor:
Nicolas Gisch, Christian Utpatel, Lisa M. Gronbach, Thomas A. Kohl, Ursula Schombel, Sven Malm, Karen M. Dobos, Danny C. Hesser, Roland Diel, Udo Götsch, Silke Gerdes, Yassir A. Shuaib, Nyanda E. Ntinginya, Celso Khosa, Sofia Viegas, Glennah Kerubo, Solomon Ali, Sahal A. Al-Hajoj, Perpetual W. Ndung’u, Andrea Rachow, Michael Hoelscher, Florian P. Maurer, Dominik Schwudke, Stefan Niemann, Norbert Reiling, Susanne Homolka
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
“Ancestral” Mycobacterium tuberculosis complex (MTBC) strains of Lineage 1 (L1, East African Indian) are a prominent tuberculosis (TB) cause in countries around the Indian Ocean. However, the pathobiology of L1 strains is insufficiently character
Externí odkaz:
https://doaj.org/article/d89af2c5cf0e449ba33491933f596aaf
Autor:
Jason L. Cantera, Lorraine M. Lillis, Roger B. Peck, Emmanuel Moreau, James A. Schouten, Paul Davis, Paul K. Drain, Alfred Andama, Abraham Pinter, Masanori Kawasaki, Gunilla Källenius, Christopher Sundling, Karen M. Dobos, Danara Flores, Delphi Chatterjee, Eileen Murphy, Olivia R. Halas, David S. Boyle
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
Lipoarabinomannan (LAM), a component of the Mycobacterium tuberculosis (MTB) cell wall, is detectable in the urine of MTB infected patients with active tuberculosis (TB). LAM-specific antibodies (Igs) have been developed by a variety of traditional a
Externí odkaz:
https://doaj.org/article/31cd732b3f6d4fec8e251e7652fb6b8c
HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells
Autor:
Melanie J. Harriff, Lisa M. Wolfe, Gwendolyn Swarbrick, Megan Null, Meghan E. Cansler, Elizabeth T. Canfield, Todd Vogt, Katelynne Gardner Toren, Wei Li, Mary Jackson, Deborah A. Lewinsohn, Karen M. Dobos, David M. Lewinsohn
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, remains a global health concern. Both classically and non-classically restricted cytotoxic CD8+ T cells are important to the control of Mtb infection. W
Externí odkaz:
https://doaj.org/article/bc18a49d1954428b9bb82c6c9deb9699
Publikováno v:
Clinical Proteomics, Vol 14, Iss 1, Pp 1-10 (2017)
Abstract Background Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), the number one cause of death due to an infectious disease. TB diagnosis is performed by microscopy, culture or PCR amplification of bacterial DNA, all
Externí odkaz:
https://doaj.org/article/86f40a8e606e470b90bd1a4c091ae1b4
Publikováno v:
Data in Brief, Vol 24, Iss , Pp - (2019)
Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhib
Externí odkaz:
https://doaj.org/article/2f138d82a79848548b66a433ea656c82
Publikováno v:
Emerging Infectious Diseases, Vol 6, Iss 2, Pp 158-164 (2000)
Buruli ulcer (BU) is an emerging necrotic skin disease caused by Mycobacterium ulcerans. To assess the potential for a serodiagnostic test, we measured the humoral immune response of BU patients to M. ulcerans antigens and compared this response with
Externí odkaz:
https://doaj.org/article/e2fe90c086c24c30bb057f3f27771158
Publikováno v:
Emerging Infectious Diseases, Vol 5, Iss 3, Pp 367-378 (1999)
Although most diseases due to pathogenic mycobacteria are caused by Mycobacterium tuberculosis, several other mycobacterial diseases—caused by M. ulcerans (Buruli ulcer), M. marinum, and M. haemophilum—have begun to emerge. We review the emergenc
Externí odkaz:
https://doaj.org/article/ef788ef782d044ba9885b1331d87263b