Zobrazeno 1 - 10 of 36 pro vyhledávání: '"Karen M. D'Souza"'
1
Activator protein-1 and caspase 8 mediate p38α MAPK-dependent cardiomyocyte apoptosis induced by palmitic acid
Autor: Charles C. Oh, John D. Lee, Kent L. Thornburg, Peter D. Reaven, Raymond Q. Migrino, Weiyang Zhang, Karen M. D'Souza
Publikováno v: Apoptosis : an international journal on programmed cell death. 24(5-6)
Lipoapoptosis of cardiomyocytes may underlie diabetic cardiomyopathy. Numerous forms of cardiomyopathies share a common end-pathway in which apoptotic loss of cardiomyocytes is mediated by p38α mitogen activated protein kinase (MAPK). Although we ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9497a451aeba5abac249a3b71637157e
https://pubmed.ncbi.nlm.nih.gov/30879166
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4
Gαq-mediated activation of GRK2 by mechanical stretch in cardiac myocytes. THE ROLE OF PROTEIN KINASE C
Autor: Karen M. D'Souza, Michelle L. Staron, Konstantin G. Birukov, Ilona Bodi, Shahab A. Akhter, Ricky Malhotra
G protein-coupled receptor kinase-2 (GRK2) is a critical regulator of β-adrenergic receptor (β-AR) signaling and cardiac function. We studied the effects of mechanical stretch, a potent stimulus for cardiac myocyte hypertrophy, on GRK2 activity and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46664d52076dce8313e6eff2e6ad33ee
https://europepmc.org/articles/PMC4933195/
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5
High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function
Autor: John C. Alverdy, Vesta Valuckaite, Tiju Theccanat, Michelle L. Staron, Shahab A. Akhter, Karen M. D'Souza, Ricky Malhotra
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 300:H1733-H1742
Apoptosis plays a significant role in maladaptive remodeling and ventricular dysfunction following ischemia-reperfusion injury. There is a critical need for novel approaches to inhibit apoptotic cell death following reperfusion, as this loss of cardi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347db343c358e3ae23055d529f933466
https://doi.org/10.1152/ajpheart.01054.2010
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6
Presynaptic stimulus-release and postsynaptic compensatory changes in mice lacking the N-type calcium channel α1B-subunit
Autor: Sheryl E. Koch, Masakazu Ishii, Arnold Schwartz, Karen M. D'Souza, Geraldine A. Fuller-Bicer, Natalia Petrashevskaya
Publikováno v: Autonomic Neuroscience. 160:9-15
N-type (Ca(v)2.2) voltage-dependent calcium channels (VDCC) play an important role in presynaptic neurotransmitter release in the autonomic nervous system and may be clinically relevant in the treatment of cardiovascular diseases. The physiological i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1ffe8a027ff03655c288a9fef8fa79
https://doi.org/10.1016/j.autneu.2010.09.007
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8
Uncoupling of Myocardial β-Adrenergic Receptor Signaling During Coronary Artery Bypass Grafting: The Role of GRK2
Autor: Christian F. Bulcao, Prakash K. Pandalai, Walter H. Merrill, Shahab A. Akhter, Karen M. D'Souza
Publikováno v: The Annals of Thoracic Surgery. 86:1189-1194
Background Cardiopulmonary bypass (CPB) and cardioplegic arrest during cardiac surgery leads to desensitization of myocardial β-adrenergic receptors (β-ARs). Impaired signaling through this pathway can have a detrimental effect on ventricular funct
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb60ba11e79ff7b292cf60d6f2ecd43
https://doi.org/10.1016/j.athoracsur.2008.05.042
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9
Acute β-blockade prevents myocardial β-adrenergic receptor desensitization and preserves early ventricular function after brain death
Autor: Jodie Y. Duffy, Karen M. D'Souza, Kelly M. McLean, Walter H. Merrill, Shahab A. Akhter, Christian F. Bulcao, Prakash K. Pandalai, Jeffrey M. Pearl
Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 135(4):792-798
Objective β-Adrenergic receptor desensitization through activation of the G protein–coupled receptor kinase 2 is an important mechanism of early cardiac dysfunction after brain death. We hypothesized that acute β-blockade can prevent myocardial
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b165cdcf833e99548b76cf12976184fb
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10
Caprine cardiac sarcoplasmic reticulum isolation and biochemical characterisation with emphasis on Ca2+-adenosine triphosphatase
Autor: Tester F. Ashavaid, Karen M. D'Souza
Publikováno v: Indian Journal of Clinical Biochemistry. 22:37-44
This study was aimed at isolating, in its pure form, and characterizing the sarcoplasmic reticulum from caprine (Capra hircus) heart. The sarcoplasmic reticulum from thirty caprine heart ventricular homogenates was isolated and purified. It was chara
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ff3ad0a18396f2ea3d7d1360920a67
https://doi.org/10.1007/bf02912879
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Plný text Recenzováno Digitální knihovna AV ČR
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