Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Karen M. Chapman"'
Autor:
David Prokai, Ashutosh Pudasaini, Mohammed Kanchwala, Andrew T. Moehlman, Alexandrea E. Waits, Karen M. Chapman, Jaideep Chaudhary, Jesus Acevedo, Patrick Keller, Xing Chao, Bruce R. Carr, F. Kent Hamra
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101880- (2021)
Summary: In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogo
Externí odkaz:
https://doaj.org/article/7a851f768b5b49019ec1a24e649bc647
Autor:
Karen M. Chapman, Gerardo A. Medrano, Priscilla Jaichander, Jaideep Chaudhary, Alexandra E. Waits, Marcelo A. Nobrega, James M. Hotaling, Carole Ober, F. Kent Hamra
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1828-1835 (2015)
Organisms with targeted genomic modifications are efficiently produced by gene editing in embryos using CRISPR/Cas9 RNA-guided DNA endonuclease. Here, to facilitate germline editing in rats, we used CRISPR/Cas9 to catalyze targeted genomic mutations
Externí odkaz:
https://doaj.org/article/3636e9614fd349e99ff5d4fa5d2528d2
Autor:
Qingping Xu, Xuehui Wang, Aaron J. Ferrell, Daniel M. Rosenbaum, Zhenhua Shao, Karthik Ramesh, Jie Yin, Karen M. Chapman, Wei Yan
Publikováno v:
Nature Chemical Biology. 15:1199-1205
The CB1 receptor mediates the central nervous system response to cannabinoids, and is a drug target for pain, anxiety and seizures. CB1 also responds to allosteric modulators, which influence cannabinoid binding and efficacy. To understand the mechan
Autor:
Lindsay Clark, Dominika Borek, Daniel M. Rosenbaum, Karen M. Chapman, Junmei Wang, Zhenhua Shao, Qingping Xu, Jie Yin
Publikováno v:
Proceedings of the National Academy of Sciences. 115:13264-13269
The NK 1 tachykinin G-protein–coupled receptor (GPCR) binds substance P, the first neuropeptide to be discovered in mammals. Through activation of NK 1 R, substance P modulates a wide variety of physiological and disease processes including nocicep
Autor:
Andrew T. Moehlman, David Prokai, Jaideep Chaudhary, Ashutosh Pudasaini, Alexandrea E. Waits, Patrick W. Keller, Mohammed Kanchwala, F. Kent Hamra, Karen M. Chapman, Jesus F. Acevedo, Bruce R. Carr, Xing Chao
Publikováno v:
iScience
iScience, Vol 24, Iss 1, Pp 101880-(2021)
iScience, Vol 24, Iss 1, Pp 101880-(2021)
Summary In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogon
Autor:
Timothy E Richardson, Karen M Chapman, Christina Tenenhaus Dann, Robert E Hammer, F Kent Hamra
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6308 (2009)
Despite remarkable advances in assisted reproductive capabilities approximately 4% of all couples remain involuntarily infertile. In almost half of these cases, a lack of conception can in some measure be attributed to the male partner, wherein de no
Externí odkaz:
https://doaj.org/article/db37524928f34a96b6e44298cb1b160f
Autor:
Zhenhua Shao, Junmei Wang, Jie Yin, Daniel M. Rosenbaum, Karen M. Chapman, Lindsay Clark, Magdalena Grzemska
Publikováno v:
Nature
The human cannabinoid G-protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-AG) and to the widely consumed plant phytocannabinoid Δ9-tetrahydrocannabinol (TH
Autor:
Jaideep Chaudhary, John M. Shelton, Gerardo A. Medrano, Xian Jin Xie, Erik J. Plautz, F. Kent Hamra, Ashutosh Pudasaini, Frauke Ackermann, Manvendra K. Singh, Craig C. Garner, James A. Richardson, Priscilla Jaichander, Levi B. Good, Heather M. Powell, Zsuzsanna Izsvák, Christine Braun, Zoltán Ivics, Karen M. Chapman
Successful sexual reproduction involves complex, genetically encoded interplay between animal physiology and behavior. The rat provides a highly fecund mammalian model for studying how the brain impacts reproduction. Here, we report a forward genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b427b18937b90eecb4ce658c09ff3ab6
https://doi.org/10.1101/405985
https://doi.org/10.1101/405985
Autor:
Lindsay Clark, George Khelashvili, James M. Aramini, Karin E J Rödström, Karen M. Chapman, Michael V. LeVine, Igor Dikiy, Kevin H. Gardner, Søren Gf Rasmussen, Daniel M. Rosenbaum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b81275f999e01e564c23e577d140d1ab
https://doi.org/10.7554/elife.28505.028
https://doi.org/10.7554/elife.28505.028
Autor:
Igor Dikiy, Karin E J Rödström, George Khelashvili, James M. Aramini, Karen M. Chapman, Michael V. LeVine, Kevin H. Gardner, Daniel M. Rosenbaum, Lindsay Clark, Søren G. F. Rasmussen
Publikováno v:
eLife
Clark, L D, Dikiy, I, Chapman, K, Rodstrom, K E J, Aramini, J, LeVine, M V, Khelashvili, G, Rasmussen, S G F, Gardner, K H & Rosebaum, D M 2017, ' Ligand modulation of sidechain dynamics in a wild-type human GPCR ', eLife, vol. 6, e28505 . https://doi.org/10.7554/eLife.28505
eLife, Vol 6 (2017)
Clark, L D, Dikiy, I, Chapman, K, Rodstrom, K E J, Aramini, J, LeVine, M V, Khelashvili, G, Rasmussen, S G F, Gardner, K H & Rosebaum, D M 2017, ' Ligand modulation of sidechain dynamics in a wild-type human GPCR ', eLife, vol. 6, e28505 . https://doi.org/10.7554/eLife.28505
eLife, Vol 6 (2017)
GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain dynamics control allosteric transi