Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Karen M Zimmerman"'
Autor:
Brian A Droz, Bria L Sneed, Charles V Jackson, Karen M Zimmerman, M Dodson Michael, Paul J Emmerson, Tamer Coskun, Richard G Peterson
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179808 (2017)
Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic mutations; these are rarely associated with the development of human obesity. A new mouse model, the FATZO mouse, has been developed to provide polyge
Externí odkaz:
https://doaj.org/article/bb9f14c1cae741f99f99a57996878039
Autor:
Richard G Peterson, Charles Van Jackson, Karen M Zimmerman, Jorge Alsina-Fernandez, M Dodson Michael, Paul J Emmerson, Tamer Coskun
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179856 (2017)
The FATZO/Pco mouse is the result of a cross of the C57BL/6J and AKR/J strains. The crossing of these two strains and the selective inbreeding for obesity, insulin resistance and hyperglycemia has resulted in an inbred strain exhibiting obesity in th
Externí odkaz:
https://doaj.org/article/fdbd942c01ab4fed9cac047452dc65e7
Autor:
Courtney Finnearty, Charles V. Jackson, Yixin Wang, Karen M. Zimmerman, Richard G. Peterson, Guodong Zhang, George E. Sandusky, Li-Kun Zhang, Gao Sun
Publikováno v:
BMC Gastroenterology
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-11 (2019)
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-11 (2019)
Background Metabolic disorders such as insulin resistance, obesity, and hyperglycemia are prominent risk factors for the development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Dietary rodent models employ high fat, high chol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d5e5aec897049aae466b28bb6f2a5a
https://doi.org/10.1186/s12876-019-0958-4
https://doi.org/10.1186/s12876-019-0958-4
Autor:
Richard G. Peterson, Karen M. Zimmerman, M. Dodson Michael, Bria L. Sneed, Paul J. Emmerson, Brian A. Droz, Charles V. Jackson, Tamer Coskun
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179808 (2017)
PLoS ONE
PLoS ONE
Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic mutations; these are rarely associated with the development of human obesity. A new mouse model, the FATZO mouse, has been developed to provide polyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff96d25ea08c7654451bfe234ee4c5a
https://doaj.org/article/bb9f14c1cae741f99f99a57996878039
https://doaj.org/article/bb9f14c1cae741f99f99a57996878039
Autor:
David Andrew Neel, Karen M. Zimmerman, Matthew L. Brown, Prabhakar Kondaji Jadhav, Robert Anthony Doti, Defauw Jean Marie, Stephon C. Smith, Peter Ambrose Lander, Sally Ann Kelley, Todd Fields, Timothy Alan Grese, Mitchell I. Steinberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2553-2557
Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1d4dba037b66ab19558a85f754cd62
https://doi.org/10.1016/j.bmcl.2005.03.086
https://doi.org/10.1016/j.bmcl.2005.03.086
Autor:
Michael K. Hansen, Norman D. Huebert, Charles V. Jackson, Karen M. Zimmerman, Richard G. Peterson, Willem de Winter
Publikováno v:
Journal of Diabetes Research
Journal of Diabetes Research, Vol 2015 (2015)
Journal of Diabetes Research, Vol 2015 (2015)
Metabolic syndrome and T2D produce significant health and economic issues. Many available animal models have monogenic leptin pathway mutations that are absent in the human population. Development of the ZDSD rat model was undertaken to produce a mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9a11f31919db9f7ece9693f8b4ecf1
https://pubmed.ncbi.nlm.nih.gov/25961053
https://pubmed.ncbi.nlm.nih.gov/25961053
Autor:
Matthew D. Belvo, Michael Gregory Bell, Douglas Linn Gernert, V. Scott Sharp, Joseph H. Kennedy, Hannah Yu, Peter Stanley Borromeo, Timothy Alan Grese, Sally Ann Kelley, Gregory A. Stephenson, Mitchell I. Steinberg, Prabhakar Kondaji Jadhav, Jeffrey D. Williams, Karen M. Zimmerman, Rachel N. Richey, Stanley P. Kolis, Peter Ambrose Lander
Publikováno v:
Journal of Medicinal Chemistry. 50:6443-6445
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7278bc07b6e6e72013351da2997c964
https://doi.org/10.1021/jm701186z
https://doi.org/10.1021/jm701186z
Autor:
Alan David Palkowitz, Donald B. Boyd, Kenneth Lee Hauser, Mitchell I. Steinberg, Karen M. Zimmerman, K. Jeff Thrasher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1015-1020
A novel series of benzimidazole angiotensin II (Ang II) receptor antagonists (4, 13, 5, 17) were synthesized and compared pharmacologically to the previously described imidazole analogues (1, 3a-b).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d0a626b825c642d1f71a428dada9e8
https://doi.org/10.1016/0960-894x(95)00159-q
https://doi.org/10.1016/0960-894x(95)00159-q
Autor:
Mitchell I. Steinberg, Kenneth Jeff Thrasher, Pfeifer William, Celia Ann Whitesitt, Kenneth Lee Hauser, Alan David Carmel Palkowitz, Karen M. Zimmerman, Sally A. Wiest, Jon K. Reel, Richard Lee Simon
Publikováno v:
Journal of Medicinal Chemistry. 37:4508-4521
cis-4-(4-Phenoxy)-1-[1-oxo-2(R)-[4-[(2-sulfobenzoyl)amino)-1H- imidazol-1-yl]octyl]-L-proline derivatives represent a novel class of potent nonpeptide angiotensin II (Ang II) receptor antagonists. These compounds evolved from directed structure-activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f4cfd5eafcb562336485c291efa4b7
https://doi.org/10.1021/jm00052a010
https://doi.org/10.1021/jm00052a010
Autor:
Donald B. Boyd, K. Takeuchi, Pfeifer William, Richard Lee Simon, Kenneth Jeff Thrasher, K.G. Bermis, Winston Stanley Marshall, Karen M. Zimmerman, Alan David Carmel Palkowitz, Jon K. Reel, Lifer Sherryl Lynn, Celia Ann Whitesitt, Sally A. Wiest, Thomas Michael Wilson, Venkatraghavan Vasudevan, Kenneth Lee Hauser, Jack B. Deeter, Mitchell I. Steinberg, Charles Jackson Barnett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:51-56
The synthesis and in vitro biological evaluation of a novel series of diastereomeric phenoxyproline octanoamides ( 3–h ) as angiotensin II (AT 1 ) receptor antagonists are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e3bf8f385807f9691ffe04c6eccbf4e
https://doi.org/10.1016/s0960-894x(01)81121-5
https://doi.org/10.1016/s0960-894x(01)81121-5