Pepsin Digest of Gliadin Forms Spontaneously Amyloid-Like Nanostructures Influencing the Expression of Selected Pro-Inflammatory, Chemoattractant, and Apoptotic Genes in Caco-2 Cells: Implications for Gluten-Related Disorders

Autor: Nicolo Tonali, Karen M Lammers, Andreas Hütten, Maria Georgina Herrera, Verónica I. Dodero, Philipp W Dörfler, Marion Gras, Inga Ennen, Francesco Nicoletti, Yvonne Hannappel, Thomas Hellweg

Publikováno v: Molecular nutritionfood research. 65(16)

SCOPE: Proteolysis-resistant gliadin peptides are intensely investigated in biomedical research related to Celiac Disease and gluten-related disorders. Herein, the first integrated supramolecular investigation of pepsin-digested gliadin peptides, p-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad794a8d45c66472b2985af2cef1a14
https://pubmed.ncbi.nlm.nih.gov/34110092

In Vitro intestinal mucosal epithelial responses to wild-typeSalmonella Typhi and attenuated typhoid vaccines

Autor: Maria eFiorentino, Karen M. Lammers, Myron M Levine, Marcelo B. Sztein, Alessio eFasano

Publikováno v: Frontiers in Immunology, Vol 4 (2013)

Typhoid fever, caused by S. Typhi, is responsible for approximately 200,000 deaths per year worldwide. Little information is available regarding epithelium-bacterial interactions in S. Typhi infection. We have evaluated in vitro the effects of wild-t

Externí odkaz: https://doaj.org/article/596af7f64ac1416ebfc1ff378bc61a7e

Proinflammatory cytokine interferon-γ and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease

Autor: Shu Yan, Gloria Serena, Shilpi Patel, Alessio Fasano, Maureen M. Leonard, Stephanie Camhi, Rosiane Lima, Karen M. Lammers, Barbara J. Nath, Rupa Mukherjee, Anna Sapone

Publikováno v: Clinical and Experimental Immunology. 187:490-506

Summary Coeliac disease (CD) is an autoimmune enteropathy triggered by gluten and characterized by a strong T helper type 1 (Th1)/Th17 immune response in the small intestine. Regulatory T cells (Treg) are CD4+CD25++forkhead box protein 3 (FoxP3+) cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec47ad0ec5d809e1a519383934030639
https://doi.org/10.1111/cei.12911

Differential Mucosal IL-17 Expression in Two Gliadin-Induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy Celiac Disease

Autor: Anna Sapone, Maria Cartenì, Karen M. Lammers, Vincenzo Casolaro, Giuseppe Mazzarella, Irina Mikhailenko, Alessio Fasano

Publikováno v: International archives of allergy and immunology 152 (2009): 75–80. doi:10.1159/000260087
info:cnr-pdr/source/autori:Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Cartenì M, Casolaro V, Fasano A./titolo:Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease./doi:10.1159%2F000260087/rivista:International archives of allergy and immunology/anno:2009/pagina_da:75/pagina_a:80/intervallo_pagine:75–80/volume:152
International archives of allergy and immunology 152 (2009): 75–80.
info:cnr-pdr/source/autori:Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Cartenì M, Casolaro V, Fasano A/titolo:Differential Mucosal IL-17 Expression in Two Gliadin-induced Disorders: Gluten Sensitivity and the Autoimmune Enteropathy Celiac Disease./doi:/rivista:International archives of allergy and immunology/anno:2009/pagina_da:75/pagina_a:80/intervallo_pagine:75–80/volume:152

Background: The immune-mediated enteropathy, celiac disease (CD), and gluten sensitivity (GS) are two distinct clinical conditions that are both triggered by the ingestion of wheat gliadin. CD, but not GS, is associated with and possibly mediated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d68f501b7917ccb8636a83ecdeba14f
https://doi.org/10.1159/000260087

Gliadin induces neutrophil migration via engagement of the formyl peptide receptor, FPR1

Autor: Tatsushi Omatsu, Carole A. Parent, Vincenzo Casolaro, Marcello Chieppa, Hans Christian Reinecker, Song Liu, Lunhua Liu, Mirkka Janka-Junttila, Karen M. Lammers, Alessio Fasano

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0138338 (2015)

Background Gliadin, the immunogenic component within gluten and trigger of celiac disease, is known to induce the production of Interleukin-8, a potent neutrophil-Activating and chemoattractant chemokine.We sought to study the involvement of neutroph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a38b6016c747a729dc04bc2cf18ce1
https://hdl.handle.net/11587/467484