LPS Triggers Acute Neuroinflammation and Parkinsonism Involving NLRP3 Inflammasome Pathway and Mitochondrial CI Dysfunction in the Rat

Autor: Irais E. Valenzuela-Arzeta, Luis O. Soto-Rojas, Yazmin M. Flores-Martinez, Karen M. Delgado-Minjares, Bismark Gatica-Garcia, Juan U. Mascotte-Cruz, Porfirio Nava, Omar Emiliano Aparicio-Trejo, David Reyes-Corona, Irma A. Martínez-Dávila, M. E. Gutierrez-Castillo, Armando J. Espadas-Alvarez, Carlos E. Orozco-Barrios, Daniel Martinez-Fong

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 5, p 4628 (2023)

Whether neuroinflammation leads to dopaminergic nigrostriatal system neurodegeneration is controversial. We addressed this issue by inducing acute neuroinflammation in the substantia nigra (SN) with a single local administration (5 µg/2 µL saline s

Externí odkaz: https://doaj.org/article/f6d9298c367a44d4b2fcd57e39ed6e6e

Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model

Autor: Adriana Morales-Martínez, Paola A. Martínez-Gómez, Daniel Martinez-Fong, Marcos M. Villegas-Rojas, Francisca Pérez-Severiano, Miguel A. Del Toro-Colín, Karen M. Delgado-Minjares, Víctor Manuel Blanco-Alvarez, Bertha Alicia Leon-Chavez, Omar Emiliano Aparicio-Trejo, Mauricio T. Baéz-Cortés, Maria-del-Carmen Cardenas-Aguayo, José Luna-Muñoz, Mar Pacheco-Herrero, Quetzalli D. Angeles-López, Irma A. Martínez-Dávila, Citlaltepetl Salinas-Lara, José Pablo Romero-López, Carlos Sánchez-Garibay, Adolfo R. Méndez-Cruz, Luis O. Soto-Rojas

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 19, p 11394 (2022)

The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson’s disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of neurons, which spreads in a

Externí odkaz: https://doaj.org/article/582d89ba51504c4487ec0c54b6e9e357

Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy

Autor: Maria E. Gutierrez-Castillo, Mar Pacheco-Herrero, Daniel Martinez-Fong, Karen M Delgado-Minjares, José Luna-Muñoz, Cecilia Bañuelos, Irma A Martínez-Dávila, Luis O Soto-Rojas, Victor Manuel Blanco-Alvarez, Maria-Del-Carmen Cardenas-Aguayo

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11702, p 11702 (2021)

Parkinson’s disease (PD) is characterized by four pathognomonic hallmarks: (1) motor and non-motor deficits; (2) neuroinflammation and oxidative stress; (3) pathological aggregates of the α-synuclein (α-syn) protein; (4) neurodegeneration of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e718a5c78cc3bb79ffc9135b8ab5ef
http://europepmc.org/articles/PMC8583859