Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Karen M Cullen"'
Autor:
Wei Wu, Joseph A Nicolazzo, Li Wen, Roger Chung, Roger Stankovic, Shisan S Bao, Chai K Lim, Bruce J Brew, Karen M Cullen, Gilles J Guillemin
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59749 (2013)
To assess the role of the kynurenine pathway in the pathology of Alzheimer's disease (AD), the expression and localization of key components of the kynurenine pathway including the key regulatory enzyme tryptophan 2,3 dioxygenase (TDO), and the metab
Externí odkaz:
https://doaj.org/article/c69cbd3ce9a345eab273769269126948
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6344 (2009)
Some of the tryptophan catabolites produced through the kynurenine pathway (KP), and more particularly the excitotoxin quinolinic acid (QA), are likely to play a role in the pathogenesis of Alzheimer's disease (AD). We have previously shown that the
Externí odkaz:
https://doaj.org/article/f5375d9cbbca4c5e9134788742c34f54
Autor:
Thuvarahan Jegathees, Glib Popov, Claire Goldsbury, Monica Vogiatzis, Patricia O. Banaczek, Gurpreet Kaur Hansra, Karen M. Cullen
Publikováno v:
Neurobiology of Aging. 82:88-101
Cerebrovascular pathology is common in aging and Alzheimer's disease (AD). The microvasculature is particularly vulnerable, with capillary-level microhemorrhages coinciding with amyloid beta deposits in senile plaques. In the current analysis, we ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d552703985c62d6c04c6c79301526e0
https://doi.org/10.1016/j.neurobiolaging.2019.06.009
https://doi.org/10.1016/j.neurobiolaging.2019.06.009
Autor:
Nabil El Massri, Sebastian P. Stefani, Napoleon Torres, Alim-Louis Benabid, John Mitrofanis, Cécile Moro, Karen M. Cullen
Publikováno v:
Experimental Brain Research. 236:955-961
In this study, we examined the cellular distribution of encephalopsin (opsin 3; OPN3) expression in the striatum of non-human primates. In addition, because of our long standing interest in Parkinson's disease and neuroprotection, we examined whether
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ccadaba11a50c3fbe9d661680ff1f0
https://doi.org/10.1007/s00221-018-5191-9
https://doi.org/10.1007/s00221-018-5191-9
Autor:
John Mitrofanis, Alim-Louis Benabid, Napoleon Torres, Katerina Arvanitakis, Diane Agay, Karen M. Cullen, Claude Chabrol, Fannie Darlot, Cécile Moro
Publikováno v:
Experimental Brain Research. 235:3081-3092
In this study, we explored the effects of a longer term application, up to 12 weeks, of photobiomodulation in normal, naïve macaque monkeys. Monkeys (n = 5) were implanted intracranially with an optical fibre device delivering photobiomodulation (re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049f2fa4763c8e977ac3bc6d70cf4c28
https://doi.org/10.1007/s00221-017-5048-7
https://doi.org/10.1007/s00221-017-5048-7
Publikováno v:
Acta Ophthalmologica. 89:e263-e268
Purpose: During retinal development, the pattern of blood vessel formation depends upon the combined effects of proliferation and migration of endothelial cells, astrocytes and Muller cells. In this study, we investigated the potential for transformi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66328fd48bce3eb68ba1521c5971ef6f
https://doi.org/10.1111/j.1755-3768.2010.01968.x
https://doi.org/10.1111/j.1755-3768.2010.01968.x
Autor:
Sarah E. Coggan, Vincent Meininger, Ross Grant, Brett Garner, Karen M. Cullen, Bruce J. Brew, Roger K. Stankovic, Yiquan Chen, Gilles J. Guillemin
Publikováno v:
Neurotoxicity Research. 18:132-142
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease of unknown pathogenesis. The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS. The KP is the major ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe510aa51aa32061b0de729e2bc69d17
https://doi.org/10.1007/s12640-009-9129-7
https://doi.org/10.1007/s12640-009-9129-7
Autor:
Othon L. Gervásio, Shane T. Antao, Karen M. Cullen, James R. Bamburg, Ineka T. Whiteman, Paul K. Witting, Gilles J. Guillemin, Claire Goldsbury, Erica V. Jeong, Laurie S. Minamide
Publikováno v:
The Journal of Neuroscience. 29:12994-13005
In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin–actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pMAP) tau form in the brain (neuropil threads), and the extent of their presence corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c07fd67107f52d37a9d44c0e4ef647c9
https://doi.org/10.1523/jneurosci.3531-09.2009
https://doi.org/10.1523/jneurosci.3531-09.2009
Autor:
Toby G. Knight, George A. Smythe, Bruce J. Brew, Karen M. Cullen, Claire E. Noonan, Gilles J. Guillemin
Publikováno v:
International Congress Series. 1304:404-408
Inflammation, chiefly in the form of activated microglia, is a feature of Alzheimer's disease (AD) pathology. The kynurenine pathway of tryptophan degradation is activated in inflammation. One of the end products of the pathway, quinolinic acid (QUIN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de83d85ff1d9f86e770beffc8a41b965
https://doi.org/10.1016/j.ics.2007.07.012
https://doi.org/10.1016/j.ics.2007.07.012
Autor:
Victoria W. K. Tung, Rajiv Wijesinghe, Karen M. Cullen, Miranda A. Mathews, Aaron J. Camp, Andrew J. Murray
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0139548 (2015)
PLoS ONE, Vol 10, Iss 9, p e0139548 (2015)
Despite the importance of our sense of balance we still know remarkably little about the central control of the peripheral balance system. While previous work has shown that activation of the efferent vestibular system results in modulation of affere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b565536bdf41a491edb81c65cc762f8
https://pubmed.ncbi.nlm.nih.gov/26422206
https://pubmed.ncbi.nlm.nih.gov/26422206