Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Karen M, Ottemann"'
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Motility promotes biofilm initiation during the early steps of this process: microbial surface association and attachment. Motility is controlled in part by chemotaxis signaling, so it seems reasonable that chemotaxis may also affect biofilm
Externí odkaz:
https://doaj.org/article/6bebd97a044c47a8826660e4c23f596b
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/611900622540491d9aab1d22dd8b4971
Autor:
Shuai Hu, Stefani Giacopazzi, Ryan Modlin, Kevin Karplus, David L. Bernick, Karen M. Ottemann
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTA cornerstone of bacterial molecular biology is the ability to genetically manipulate the microbe under study. Many bacteria are difficult to manipulate genetically, a phenotype due in part to robust removal of newly acquired DNA, for example
Externí odkaz:
https://doaj.org/article/b2797905ee694e2f84a7130ca48a466b
Autor:
Shuai Hu, Karen M. Ottemann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
The complement system is a key protective response against infectious pathogens. Here, the authors show that Helicobacter pylori uses host L-lactate to generate a complement resistant state that promotes gastric colonisation.
Externí odkaz:
https://doaj.org/article/c61be460eb1948d88915664a4b40e846
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT The flagellar motor protein FliL is conserved across many microbes, but its exact role has been obscured by varying fliL mutant phenotypes. We reanalyzed results from fliL studies and found they utilized alleles that differed in the amount o
Externí odkaz:
https://doaj.org/article/7d92007001d14a49828768a09315a913
Autor:
Kevin S. Johnson, Bassam A. Elgamoudi, Freda E.-C. Jen, Christopher J. Day, Emily Goers Sweeney, Megan L. Pryce, Karen Guillemin, Thomas Haselhorst, Victoria Korolik, Karen M. Ottemann
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The Helicobacter pylori chemoreceptor TlpA plays a role in dampening host inflammation during chronic stomach colonization. TlpA has a periplasmic dCache_1 domain, a structure that is capable of sensing many ligands; however, the only charac
Externí odkaz:
https://doaj.org/article/958587dd065b4f2d967bac45ac018790
Publikováno v:
Trends in Microbiology. 31:539-543
Autor:
Francesca I. Batac, Melissa A. Miller, Megan E. Moriarty, Zeli Shen, James G. Fox, Karen M. Ottemann
Publikováno v:
Frontiers in Marine Science, Vol 7 (2020)
Southern sea otters (Enhydra lutris nereis) are threatened marine mustelids that commonly have gastric ulcers with secondary hemorrhage (melena) as a contributing cause of death. Although Helicobacter spp. infections are known to cause gastric ulcers
Externí odkaz:
https://doaj.org/article/85f9e3fa9de44108ba32ee0992e82008
Autor:
Isabelle C. Arnold, Xiaozhou Zhang, Sabine Urban, Mariela Artola-Borán, Markus G. Manz, Karen M. Ottemann, Anne Müller
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3860-3872 (2017)
The gastric lamina propria is largely uncharted immunological territory. Here we describe the evolution and composition of the gastric, small intestinal, and colonic lamina propria mononuclear phagocyte system during the steady state and infection wi
Externí odkaz:
https://doaj.org/article/69a2e866129f48cf841b868243031bb1
Autor:
Mayra A. Machuca, Kevin S. Johnson, Yu C. Liu, David L. Steer, Karen M. Ottemann, Anna Roujeinikova
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract It is recently appreciated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a structure with two PAS-like subdomains, one membrane-proximal and the other membrane-distal. Previous studies had implica
Externí odkaz:
https://doaj.org/article/70d3bd8e624444ddaa9c81528f895161