Experimental non-alcoholic fatty liver disease causes regional liver functional deficits as measured by the capacity for galactose metabolism while whole liver function is preserved

Autor: Peter Lykke Eriksen, Karen Louise Thomsen, Stephen Hamilton-Dutoit, Hendrik Vilstrup, Michael Sørensen

Publikováno v: BMC Gastroenterology, Vol 22, Iss 1, Pp 1-10 (2022)

Abstract Background Increasing incidence of non-alcoholic fatty liver disease (NAFLD) calls for improved understanding of how the disease affects metabolic liver function. Aims To investigate in vivo effects of different NAFLD stages on metabolic liv

Externí odkaz: https://doaj.org/article/1106db9411ea4699941ae5343c9630a6

Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis

Autor: Henrik H. Hansen, Helene M. Ægidius, Denise Oró, Simon S. Evers, Sara Heebøll, Peter Lykke Eriksen, Karen Louise Thomsen, Anja Bengtsson, Sanne S. Veidal, Michel Feigh, Malte P. Suppli, Filip K. Knop, Henning Grønbæk, Diego Miranda, James L. Trevaskis, Niels Vrang, Jacob Jelsing, Kristoffer T. G. Rigbolt

Publikováno v: BMC Gastroenterology, Vol 20, Iss 1, Pp 1-12 (2020)

Abstract Background Animal models of non-alcoholic steatohepatitis (NASH) are important tools in preclinical research and drug discovery. Gubra-Amylin NASH (GAN) diet-induced obese (DIO) mice represent a model of fibrosing NASH. The present study dir

Externí odkaz: https://doaj.org/article/738511df0fdc4d36be87fd7875e0fda9

Validation of CLIF-C ACLF score to define a threshold for futility of intensive care support for patients with acute-on-chronic liver failure

Autor: Cornelius Engelmann, Karen Louise Thomsen, Nekisa Zakeri, Mohammed Sheikh, Banwari Agarwal, Rajiv Jalan, Rajeshwar P. Mookerjee

Publikováno v: Critical Care, Vol 22, Iss 1, Pp 1-8 (2018)

Abstract Background Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis and is defined by organ failure and high rates of short-term mortality. Patients with ACLF are managed with multiorgan support in the intensive care unit

Externí odkaz: https://doaj.org/article/16ee0b14a9d048d6b7d19d4c101608fb

Clinical and Pathophysiological Characteristics of Cirrhotic Patients with Grade 1 and Minimal Hepatic Encephalopathy.

Autor: Karen Louise Thomsen, Jane Macnaughtan, Giovanni Tritto, Rajeshwar P Mookerjee, Rajiv Jalan

Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0146076 (2016)

EASL/AASLD hepatic encephalopathy (HE) guidelines proposed the alternative use of the term 'Covert HE' combining minimal HE (mHE) and Grade 1 HE into a single entity. However, longitudinal data to indicate that these are indeed a single entity are la

Externí odkaz: https://doaj.org/article/fe2a29750e2b493d8565c1413dcb84b0

Role of ammonia in NAFLD:An unusual suspect

Autor: Karen Louise Thomsen, Peter Lykke Eriksen, Annarein JC. Kerbert, Francesco De Chiara, Rajiv Jalan, Hendrik Vilstrup

Publikováno v: Thomsen, K L, Eriksen, P L, Kerbert, A JC, De Chiara, F, Jalan, R & Vilstrup, H 2023, ' Role of ammonia in NAFLD : An unusual suspect ', JHEP Reports, vol. 5, no. 7, 100780 . https://doi.org/10.1016/j.jhepr.2023.100780

Mechanistically, the symptomatology and disease progression of non-alcoholic fatty liver disease (NAFLD) remain poorly understood, which makes therapeutic progress difficult. In this review, we focus on the potential importance of decreased urea cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151052a3321f29d4cd7931bdf1fd109c
https://pure.au.dk/portal/da/publications/role-of-ammonia-in-nafld(74cae5fd-4d00-483e-91bd-3c72b5bf7c5b).html