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The cytokine macrophage migration inhibitory factor (MIF) acts as a neurotrophin in the developing inner ear of the zebrafish, Danio rerio

Autor: Alexander Chong Shu-Chien, Karen L. Wu, Meng-Kiat Kuah, Kah Loon Wong, Ethan M. Jewett, Kate F. Barald, Yu Chi Shen, Deborah L. Thompson, Stephanie A. Linn

Publikováno v: Developmental Biology. 363(1):84-94

Macrophage migration inhibitory factor (MIF) plays versatile roles in the immune system. MIF is also widely expressed during embryonic development, particularly in the nervous system, although its roles in neural development are only beginning to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1c7c804ba8a77e4bc537314c7e98b8

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Immunofluorescence Tomography of Mouse Ocular Surface Epithelial Stem Cells and Their Niche Microenvironment

Autor: Behdad Kavianpour, Donald J. Brown, Geraint J. Parfitt, Yilu Xie, Karen L. Wu, James V. Jester

Publikováno v: Investigative ophthalmology & visual science, vol 56, iss 12

Purpose: Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b6968ace1270d52273965b857e751f
https://pubmed.ncbi.nlm.nih.gov/26559480

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The NHE1 Na+/H+ Exchanger Recruits Ezrin/Radixin/Moesin Proteins to Regulate Akt-dependent Cell Survival

Autor: George Jarad, Martha Konieczkowski, Carlos A. Obejero-Paz, Amitava Mukherjee, Sujata Lakhe-Reddy, Jeffrey R. Schelling, Karen L. Wu, Shenaz Khan, John R. Sedor

Publikováno v: Journal of Biological Chemistry. 279:26280-26286

Apoptosis results in cell shrinkage and intracellular acidification, processes opposed by the ubiquitously expressed NHE1 Na(+)/H(+) exchanger. In addition to mediating Na(+)/H(+) transport, NHE1 interacts with ezrin/radixin/moesin (ERM), which tethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207be46420fc9d425f970020b3d8941c
https://doi.org/10.1074/jbc.m400814200

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Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE1 Na+/H+exchanger

Autor: John R. Sedor, Sujata Lakhe-Reddy, R. Tyler Miller, Liming Wang, Arthur M. Brown, Jeffrey R. Schelling, Shenaz Khan, Martha Konieczkowski, Karen L. Wu, George Jarad

Publikováno v: American Journal of Physiology-Renal Physiology. 284:F829-F839

Renal tubular epithelial cell (RTC) apoptosis causes tubular atrophy, a hallmark of renal disease progression. Apoptosis is generally characterized by reduced cell volume and cytosolic pH, but epithelial cells are relatively resistant to shrinkage du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b95775b0718afe26153851d58e43918
https://doi.org/10.1152/ajprenal.00314.2002

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The transmembrane inner ear (tmie) gene contributes to vestibular and lateral line development and function in the zebrafish (Danio rerio)

Autor: Kate F. Barald, Dong Liu, Yu Chi Shen, Anandhi K. Jeyabalan, Kristina L. Hunker, Deborah L. Thompson, David C. Kohrman, Karen L. Wu

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists. 237(4)

The inner ear is a complex organ containing sensory tissue, including hair cells, the development of which is not well understood. Our long-term goal is to discover genes critical for the correct formation and function of the inner ear and its sensor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01925ac80c03234f97077b69ded591e
https://pubmed.ncbi.nlm.nih.gov/18330929

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JAK kinases promote invasiveness in VHL-mediated renal cell carcinoma by a suppressor of cytokine signaling-regulated, HIF-independent mechanism

Autor: Hui Miao, Shenaz Khan, Karen L. Wu

Publikováno v: American journal of physiology. Renal physiology. 293(6)

von Hippel-Lindau (VHL) disease is a cancer syndrome, which includes renal cell carcinoma (RCC), and is caused by VHL mutations. Most, but not all VHL phenotypes are due to failure of mutant VHL to regulate constitutive proteolysis of hypoxia-inducib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f401ad2afb23b419b324c707d43f57d8
https://pubmed.ncbi.nlm.nih.gov/17898043

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