Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Karen L. Reddy"'
Autor:
Xianrong Wong, Victoria E. Hoskins, Ashley J. Melendez-Perez, Jennifer C. Harr, Molly Gordon, Karen L. Reddy
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Abstract Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery. Evidenc
Externí odkaz:
https://doaj.org/article/c3c02a39c176426f994be672983a5aeb
Publikováno v:
Cold Spring Harbor perspectives in biology. 14(2)
Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear subcompartment, the nuclear lamina, that is involved in a variet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30177ea3f663da5e5dd8644ee0dd143
https://pubmed.ncbi.nlm.nih.gov/34400553
https://pubmed.ncbi.nlm.nih.gov/34400553
Autor:
Shiwei Chen, Teresa Romeo Luperchio, Xianrong Wong, Europe B. Doan, Aaron T. Byrd, Kingshuk Roy Choudhury, Karen L. Reddy, Michael S. Krangel
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1729-1740.e6 (2018)
Summary: Tcrb locus V(D)J recombination is regulated by positioning at the nuclear periphery. Here, we used DamID to profile Tcrb locus interactions with the nuclear lamina at high resolution. We identified a lamina-associated domain (LAD) border com
Externí odkaz:
https://doaj.org/article/630ebbe68829489bb0b52e0dd6731e9c
Autor:
Karen L. Reddy, Xianrong Wong, Jennifer C. Harr, Ashley J. Melendez-Perez, Victoria E. Hoskins, Molly Gordon
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-27 (2021)
Genome Biology
Genome Biology
Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery. Evidence suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d727b702f44b0eca5731eba60b49cb8
https://doaj.org/article/c3c02a39c176426f994be672983a5aeb
https://doaj.org/article/c3c02a39c176426f994be672983a5aeb
Autor:
Amir Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Yu Long Han, Chan Young Park, Mark Kittisopikul, Xianrong Wong, Joseph R. Tran, Gregg G. Gundersen, Karen L. Reddy, G. W. Gant Luxton, Ming Guo, Jeffrey J. Fredberg, Yixian Zheng, Stephen A. Adam, Robert D. Goldman
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30db962e59a0d9fa90a517242523184b
https://doi.org/10.1073/pnas.2121816119
https://doi.org/10.1073/pnas.2121816119
Autor:
Yohei Kono, Stephen A. Adam, Karen L. Reddy, Yixian Zheng, Ohad Medalia, Robert D. Goldman, Hiroshi Kimura, Takeshi Shimi
In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to maintain nuclear structure. The nuclear lamins, the major structural components of the NL, are involved in the protection against NE rupture induced by mechanica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510271aaa8cae0f7088a3f68c5e54aed
https://doi.org/10.1101/2022.01.05.475028
https://doi.org/10.1101/2022.01.05.475028
Autor:
Sang Hyuk Lee, Nick Longe, Karen L. Reddy, Angela Jimenez, Denis Wirtz, Tania Perestrelo, Teresa Romeo Luperchio, Byoung Choul Kim, Jude M. Phillip, Ivie Aifuwa, Taekjip Ha
The presence of senescent cells within tissues has been functionally linked to malignant transformations. Here, using tension-gauge tethers technology, particle-tracking microrheology, and quantitative microscopy, we demonstrate that senescent associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9e33042c3b201136bfb5fce082e043
https://doi.org/10.1101/2021.11.17.468902
https://doi.org/10.1101/2021.11.17.468902
Autor:
Romeo Papazyan, Ekaterina Voronina, Jessica R Chapman, Teresa R Luperchio, Tonya M Gilbert, Elizabeth Meier, Samuel G Mackintosh, Jeffrey Shabanowitz, Alan J Tackett, Karen L Reddy, Robert S Coyne, Donald F Hunt, Yifan Liu, Sean D Taverna
Publikováno v:
eLife, Vol 3 (2014)
Despite the well-established role of heterochromatin in protecting chromosomal integrity during meiosis and mitosis, the contribution and extent of heterochromatic histone posttranslational modifications (PTMs) remain poorly defined. Here, we gained
Externí odkaz:
https://doaj.org/article/3b35a1690d62462ab52742108536ee6e
Autor:
Stephen A. Adam, Karen L. Reddy, Suganya Sivagurunathan, Chan Young Park, Robert D. Goldman, Yixian Zheng, Tran, Wong X, Jeffrey J. Fredberg, Gregg G. Gundersen, Amir Vahabikashi, Nicdao Fas, Ming Guo, Yu Long Han, Luxton Gg
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59d2872e5ecc95c3d1aa2059959c0ddd
https://doi.org/10.1101/2021.05.12.443683
https://doi.org/10.1101/2021.05.12.443683
Autor:
Jevon Cutler, Xianrong Wong, Karen L. Reddy, Anil K. Madugundu, Molly Gordon, Akhilesh Pandey, Victoria E. Hoskins
Publikováno v:
Life Science Alliance
The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
The nuclear lamina is a
The nuclear lamina is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a47c246418ecb8b3042d96ccdedcc84
http://europepmc.org/articles/PMC8008952
http://europepmc.org/articles/PMC8008952