Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Karen L. Posey"'
Autor:
Karen L. Posey
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 154 (2024)
Natural products with health benefits, nutraceuticals, have shown considerable promise in many studies; however, this potential has yet to translate into widespread clinical use for any condition. Notably, many drugs currently on the market, includin
Externí odkaz:
https://doaj.org/article/a951e431708c45e1bb23542f0a4dbe7f
Autor:
Jacqueline T. Hecht, Alka C. Veerisetty, Debabrata Patra, Mohammad G. Hossain, Frankie Chiu, Claire Mobed, Francis H. Gannon, Karen L. Posey
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1553 (2023)
Pseudoachondroplasia (PSACH), a severe dwarfing condition associated with early-onset joint degeneration and lifelong joint pain, is caused by mutations in cartilage oligomeric matrix protein (COMP). The mechanisms underlying the mutant-COMP patholog
Externí odkaz:
https://doaj.org/article/b610757a893145d5a7269de90cf02d63
Autor:
Alexander Burger, Jasmien Roosenboom, Mohammad Hossain, Seth M. Weinberg, Jacqueline T. Hecht, Karen L. Posey
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 7, Pp n/a-n/a (2020)
Abstract Background Cartilage oligomeric matrix protein (COMP) is an important extracellular matrix protein primarily functioning in the musculoskeletal tissues and especially endochondral bone growth. Mutations in COMP cause the skeletal dysplasia p
Externí odkaz:
https://doaj.org/article/7b8b27043b74438f9c17333176c6a3c0
Publikováno v:
Matrix Biology. 119:101-111
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dcb27afcfe4744a5f2a4198aba97846
https://doi.org/10.1016/j.matbio.2023.03.008
https://doi.org/10.1016/j.matbio.2023.03.008
Publikováno v:
JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021)
ABSTRACT Misfolding mutations in cartilage oligomeric matrix protein (COMP) cause it to be retained within the endoplasmic reticulum (ER) of chondrocytes, stimulating a multitude of damaging cellular responses including ER stress, inflammation, and o
Externí odkaz:
https://doaj.org/article/db0eaf11f45f4301991c1eb0ac2df3fc
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3845
Volume 24
Issue 4
Pages: 3845
Mutations in cartilage oligomeric matrix protein (COMP) causes protein misfolding and accumulation in chondrocytes that compromises skeletal growth and joint health in pseudoachondroplasia (PSACH), a severe dwarfing condition. Using the MT-COMP mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685b9366363063f88f3c2e7e87a0c9da
Autor:
Francoise Coustry, Karen L. Posey, Alka C. Veerisetty, Frankie Chiu, Mohammad G. Hossain, Francis H. Gannon, Jacqueline T. Hecht, Juliana Wu
Publikováno v:
Am J Pathol
Increasing numbers of people are living with osteoarthritis (OA) due to aging and obesity, creating an urgent need for effective treatment and preventions. Two top risk factors for OA, age and obesity, are associated with endoplasmic reticulum (ER) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55442fa40ef6d70bac07989f15cb2398
https://doi.org/10.1016/j.ajpath.2021.05.016
https://doi.org/10.1016/j.ajpath.2021.05.016
Autor:
Karen L. Posey, Mohammad G. Hossain, Jacqueline T. Hecht, Michael J. Gambello, Francoise Coustry, Alka C. Veerisetty
Publikováno v:
The American Journal of Pathology. 189:132-146
Cartilage oligomeric matrix protein (COMP) is a large, multifunctional extracellular protein that, when mutated, is retained in the rough endoplasmic reticulum (ER). This retention elicits ER stress, inflammation, and oxidative stress, resulting in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8746f6cdcb983c15057d1c7673e45a
https://doi.org/10.1016/j.ajpath.2018.09.008
https://doi.org/10.1016/j.ajpath.2018.09.008
Autor:
Jacqueline T. Hecht, Francoise Coustry, Debabrata Patra, Alka C. Veerisetty, Frankie Chiu, Mohammad G. Hossain, Karen L. Posey
Pseudoachondroplasia (PSACH), a short limb skeletal dysplasia, associated with premature joint degeneration is caused by misfolding mutations in cartilage oligomeric matrix protein (COMP). Here, we define mutant-COMP-induced stress mechanisms that oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb4769245b4160ff3fcf9aaacdc67488
https://doi.org/10.1101/2021.06.04.447121
https://doi.org/10.1101/2021.06.04.447121
Autor:
Karen L. Posey, Mohammad G. Hossain, Jacqueline T. Hecht, Francoise Coustry, Alka C. Veerisetty
Publikováno v:
JBMR Plus
JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021)
JBMR Plus, Vol 5, Iss 3, Pp n/a-n/a (2021)
Misfolding mutations in cartilage oligomeric matrix protein (COMP) cause it to be retained within the endoplasmic reticulum (ER) of chondrocytes, stimulating a multitude of damaging cellular responses including ER stress, inflammation, and oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318024a433bbd415ce783a809b82bdea
http://europepmc.org/articles/PMC7990140
http://europepmc.org/articles/PMC7990140