Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Karen L. MacKenzie"'
Autor:
Emma L. Boys, Bo Gao, Peter Grimison, Sarah Sutherland, Karen L. MacKenzie, Roger R. Reddel, Jia Liu
Publikováno v:
Cancer Medicine, Vol 13, Iss 6, Pp n/a-n/a (2024)
Abstract Background Carcinoma of unknown primary (CUP) remains an important tumor entity and a disproportionate cause of cancer mortality. Little is known about the contemporary clinical characteristics, treatment patterns, and outcomes of CUP patien
Externí odkaz:
https://doaj.org/article/494522827b2640a9b18ea875ea07cdde
Autor:
Laura A. Richards, Ashu Kumari, Kathy Knezevic, Julie AI Thoms, Georg von Jonquieres, Christine E. Napier, Zara Ali, Rosemary O’Brien, Jonathon Marks-Bluth, Michelle F. Maritz, Hilda A Pickett, Jonathan Morris, John E. Pimanda, Karen L. MacKenzie
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Telomerase is a ribonucleoprotein complex that maintains the length and integrity of telomeres, and thereby enables cellular proliferation. Understanding the regulation of telomerase in hematopoietic cells is relevant to the pathogenesis of leukemia,
Externí odkaz:
https://doaj.org/article/ee07ad5c6c0249799f5927f0f6b11e13
Autor:
Ashwin Unnikrishnan, Elli Papaemmanuil, Dominik Beck, Nandan P. Deshpande, Arjun Verma, Ashu Kumari, Petter S. Woll, Laura A. Richards, Kathy Knezevic, Vashe Chandrakanthan, Julie A.I. Thoms, Melinda L. Tursky, Yizhou Huang, Zara Ali, Jake Olivier, Sally Galbraith, Austin G. Kulasekararaj, Magnus Tobiasson, Mohsen Karimi, Andrea Pellagatti, Susan R. Wilson, Robert Lindeman, Boris Young, Raj Ramakrishna, Christopher Arthur, Richard Stark, Philip Crispin, Jennifer Curnow, Pauline Warburton, Fernando Roncolato, Jacqueline Boultwood, Kevin Lynch, Sten Eirik W. Jacobsen, Ghulam J. Mufti, Eva Hellstrom-Lindberg, Marc R. Wilkins, Karen L. MacKenzie, Jason W.H. Wong, Peter J. Campbell, John E. Pimanda
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 572-585 (2017)
Myelodysplastic syndromes and chronic myelomonocytic leukemia are blood disorders characterized by ineffective hematopoiesis and progressive marrow failure that can transform into acute leukemia. The DNA methyltransferase inhibitor 5-azacytidine (AZA
Externí odkaz:
https://doaj.org/article/fb18143a8ba041a5a64d9408be566baa
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background RNA-Seq is now widely used as a research tool. Choices must be made whether to use paired-end (PE) or single-end (SE) sequencing, and whether to use strand-specific or non-specific (NS) library preparation kits. To date there has
Externí odkaz:
https://doaj.org/article/e3622af371af4412aacec3d047c7a3ea
Autor:
Victoria W. Wen, Karen L. MacKenzie
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1066-1079 (2013)
Endothelial cell (EC)-derived neoplasias range from benign hemangioma to aggressive metastatic angiosarcoma, which responds poorly to current treatments and has a very high mortality rate. The development of treatments that are more effective for the
Externí odkaz:
https://doaj.org/article/dcaf988723804a9ba8ab746e8927877c
Human leukemia cells secrete VEGF, which can act in a paracrine manner within the bone marrow microenvironment to promote leukemia cell survival and proliferation. The FLT-3 receptor tyrosine kinase plays an essential role in regulating normal hemato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34596041c9f5010309fb20c9b97e9aed
https://doi.org/10.1158/1535-7163.c.6535948
https://doi.org/10.1158/1535-7163.c.6535948
Autor:
Tao Liu, Hilda A. Pickett, Xu D. Zhang, Matthias Fischer, Michelle Haber, Murray D. Norris, Roger R. Reddel, Glenn M. Marshall, Patsie Polly, Jinyan Li, Alla Dolnikov, Karen L. MacKenzie, Mark J. Cowley, Isabelle Janoueix-Lerosey, Jenny Y. Wang, Valentina Boeva, Valerie Combaret, Jo Vandesompele, Pieter Mestdagh, Tracy M. Bryan, Qing Lan, Belamy B. Cheung, Bernard Atmadibrata, Hui Peng, Marie Wong, Nisitha Jayatilleke, Ning Xu, Toby N. Trahair, Christoph Bartenhagen, Chelsea Mayoh, Alvin Kamili, Jamie I. Fletcher, Ting La, Pei Y. Liu, Andrew E. Tee, Matthew Wong, Christopher Nelson, Jingwei Chen
Supplementary Figure S4. Combination of the BET bromodomain inhibitor I-BET762 and chemotherapy agents, but not proteasome inhibitors, induces cytotoxicity to normal cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1076053a3d7acbe1ccbe1d52d7c939cd
https://doi.org/10.1158/1078-0432.22479843.v1
https://doi.org/10.1158/1078-0432.22479843.v1
Autor:
Tao Liu, Hilda A. Pickett, Xu D. Zhang, Matthias Fischer, Michelle Haber, Murray D. Norris, Roger R. Reddel, Glenn M. Marshall, Patsie Polly, Jinyan Li, Alla Dolnikov, Karen L. MacKenzie, Mark J. Cowley, Isabelle Janoueix-Lerosey, Jenny Y. Wang, Valentina Boeva, Valerie Combaret, Jo Vandesompele, Pieter Mestdagh, Tracy M. Bryan, Qing Lan, Belamy B. Cheung, Bernard Atmadibrata, Hui Peng, Marie Wong, Nisitha Jayatilleke, Ning Xu, Toby N. Trahair, Christoph Bartenhagen, Chelsea Mayoh, Alvin Kamili, Jamie I. Fletcher, Ting La, Pei Y. Liu, Andrew E. Tee, Matthew Wong, Christopher Nelson, Jingwei Chen
Re - Revised Supplementary Materials & Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b122c41b80feca5f4aa3526268100e4
https://doi.org/10.1158/1078-0432.22479831
https://doi.org/10.1158/1078-0432.22479831
Autor:
Tao Liu, Hilda A. Pickett, Xu D. Zhang, Matthias Fischer, Michelle Haber, Murray D. Norris, Roger R. Reddel, Glenn M. Marshall, Patsie Polly, Jinyan Li, Alla Dolnikov, Karen L. MacKenzie, Mark J. Cowley, Isabelle Janoueix-Lerosey, Jenny Y. Wang, Valentina Boeva, Valerie Combaret, Jo Vandesompele, Pieter Mestdagh, Tracy M. Bryan, Qing Lan, Belamy B. Cheung, Bernard Atmadibrata, Hui Peng, Marie Wong, Nisitha Jayatilleke, Ning Xu, Toby N. Trahair, Christoph Bartenhagen, Chelsea Mayoh, Alvin Kamili, Jamie I. Fletcher, Ting La, Pei Y. Liu, Andrew E. Tee, Matthew Wong, Christopher Nelson, Jingwei Chen
Purpose:TERT gene rearrangement with transcriptional superenhancers leads to TERT overexpression and neuroblastoma. No targeted therapy is available for clinical trials in patients with TERT-rearranged neuroblastoma.Experimental Design:Anticancer age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034780d3887e48b57e665f0eda3bd202
https://doi.org/10.1158/1078-0432.c.6530307
https://doi.org/10.1158/1078-0432.c.6530307