Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karen L. Huss"'
Autor:
Kenneth D. Roth, Saravanan Parthasarathy, Tao Wang, Robert L. Shepard, Burkholder Timothy P, Zhao Hai Lu, Gillig James Ronald, Timothy I. Meier, Karen L. Huss, Ming-Shang Kuo, Bo Tan, Genshi Zhao, Yan Zhai, Michele C. Smith, Sandaruwan Geeganage, Debra A. Young
Publikováno v:
Journal of Biological Chemistry. 288:3500-3511
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism, energy production, and DNA repair. NAMPT has been extensively studied because of its critical
Autor:
Lillian Sams, Sandaruwan Geeganage, Michael Kalos, Andrew L. Faber, Frank C. Dorsey, Daniel Jon Sall, David K. Clawson, John F. Schindler, William T. McMillen, Zhao Gaiying, Bonita D. Jones, Karim A. Benhadji, Debra A. Young, Carmine Carpenito, Henry James Robert, James E. Thomas, Steven Haney, Tod Smeal, Karen L. Huss, Alexander Nikolayev
Publikováno v:
Cancer Research. 78:5245-5245
Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-dependent enzyme that catalyzes the initial and rate-limiting step of tryptophan catabolism resulting in the local depletion of tryptophan and the concomitant production of kynurenine, both of which are
Autor:
Laura J. Bloem, Chaitanya Saxena, Tabetha M. Bonacci, John E. Hale, Richard E. Higgs, Karen L. Huss
Publikováno v:
Journal of Proteome Research. 8:3951-3957
Recently we have described the development of an Immuno-chemo-proteomics method for drug target deconvolution and profiling the toxicity of known drugs ( Saxena , C. ; Zhen , E. ; Higgs , R. E. ; Hale , J. E. J. Proteome Res. 2008, 8 , 3490 - 3497 ).
Autor:
Karen L. Huss, Charles R. Heap, William T. McMillen, David K. Clawson, Jonathan M. Yingling, J. Scott Sawyer, Robert M. Campbell, Matthew D. Voss, Bryan D. Anderson, Chi Hsin R. King, Elizabeth A. Dierks, Hong Yu Li, Wang Yan, Lei Yan, Sreenivasa Reedy Mundla, Karen S. Britt, Denis J. McCann
Publikováno v:
Journal of Medicinal Chemistry. 51:2302-2306
In our continuing effort to expand the SAR of the quinoline domain of dihydropyrrolopyrazole series, we have discovered compound 15d, which demonstrated the antitumor efficacy with oral bioavailability. This effort also demonstrated that the PK/PD in
Autor:
Karen L. Huss, Mclean Johnathan Alexander, Zhao Gaiying, Robert S. Flack, Andrew J. Dropsey, Xueqian Gong, Michael John Rodriguez, Sajan Joseph, Matthew Whitesell, Lisa Kindler, Jennie L. Walgren, Jason Manro, Ramon V. Tiu, Baohui Zhao, Brian Michael Mathes, Denis J. McCann, Xiu-Juan Yuan, Susan Jaken, Shufen Cai, Bryan D. Anderson, William T. McMillen, Eunice Yuen, Shripad V. Bhagwat, Cortez Guillermo S, Wenjuan Wu
Publikováno v:
Cancer Research. 77:3231-3231
The ERK/MAPK pathway plays a central role in the regulation of critical cellular processes and is activated in more than 30% of human cancers. While targeting upstream nodes with RAF and MEK inhibitors has proven effective clinically, resistance freq
Autor:
Ramon V. Tiu, Brian Michael Mathes, Xueqian Gong, Bryan D. Anderson, Michael John Rodriguez, William T. McMillen, Shufen Cai, Andrew J. Dropsey, Eunice Yuen, Wenjuan Wu, Lisa Kindler, Robert S. Flack, Sajan Joseph, Susan Jaken, Karen L. Huss, Jennie L. Walgren, Matthew Whitesell, Baohui Zhao, Sheng-Bin Peng, Denis J. McCann, Xiu-Juan Yuan, Shripad V. Bhagwat, Jianping Huang, Jason Manro
Publikováno v:
Cancer Research. 77:4973-4973
The RAS/MAPK pathway is dysregulated in approximately 30% of human cancers, and the extracellular-signal-regulated kinases (ERK1 and ERK2) serves as key central nodes within this pathway. The feasibility and clinical impact of targeting the RAS/MAPK
Autor:
Karen L. Huss, Daohong Chen, Genshi Zhao, Sheng Bin Peng, Zhaogen Chen, Yan Zhai, Mohammad Zia-Ebrahimi, Wei Ying Li, Laura J. Bloem, Henry James Robert, Hongyu Li, Denis J. McCann
Publikováno v:
Molecular cancer therapeutics. 10(11)
The fibroblast growth factor receptors (FGFR) are tyrosine kinases that are present in many types of endothelial and tumor cells and play an important role in tumor cell growth, survival, and migration as well as in maintaining tumor angiogenesis. Ov
Publikováno v:
Journal of biomolecular screening. 12(4)
A Transcreener™ kinase fluorescence polarization (FP) assay has been developed for the serine/threonine kinase protein kinase A (PKA). The PKA Transcreener™ kinase assay is an homogenous, competitive antibody-based FP assay that uses Far Red Alex
Autor:
Philip W. Iversen, Donald Thornton, Ann M. McNulty, Sandaruwan Geeganage, Karen L. Huss, Thomas J. Brown, Luna Musib, Robert M. Campbell, Andrew Capen, Blake Lee Neubauer, Crystal Banks, Lillian Sams, Spring N. Bailey, Rebecca L. Lynch, Robin L. Goode, Jason E. Lewis, Bruce W. Konicek, Kimberly R. Hanna, Jeremy R. Graff
Publikováno v:
Cancer research. 65(16)
Activation of protein kinase Cβ (PKCβ) has been repeatedly implicated in tumor-induced angiogenesis. The PKCβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses angiogenesis and was advanced for clinical development based upon this antian
Autor:
Shila Jalali, Manuel A. Jimenez, Siobhan M. Miick, Donald S. Thomas, Betsy Zile, Robert M. Campbell, John R. Havens, Brian P. Dwyer, Karen L. Huss, Mathew T. Simpson
Publikováno v:
Journal of biomolecular screening. 10(4)
A microplate-based electrophoretic assay has been developed for the serine/threonine kinase protein kinase A (PKA). The ElectroCapture™ PKA assay developed uses a positively charged, lissamine-rhodamine-labeled kemptide peptide substrate for the ki