Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karen L. Fearon"'
Autor:
Christi Abbate, Karen L. Fearon, Tracy dela Cruz, Debbie Higgins, Gary Van Nest, David Passmore, Jason Marshall, Stephen Tuck, Gary Ott, Priscilla Yee, Glen Teshima
Publikováno v:
Cellular Immunology. 229:93-105
The immunostimulatory effects of bacterial DNA on mammalian cells have been localized to unmethylated CpG motifs, and synthetic CpG-containing oligodeoxynucleotides that mimic these effects are known as immunostimulatory sequences (ISS). We have foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157d5f2381cd844b670c6aa8ebdfc3b6
https://doi.org/10.1016/j.cellimm.2004.04.009
https://doi.org/10.1016/j.cellimm.2004.04.009
Autor:
David H. Lloyd, Kevin Corcoran, George Stefan Golda, Michael F. Foy, James W. Kirchner, Rithy Roth, Sydney Brenner, Sarah N. McCurdy, Dave George, Robert B. Dubridge, Sam Eletr, Mark Ewan, Steven Williams, Maria Johnson, Eric Vermaas, John Bridgham, Michael C. Pallas, Timothy Burcham, Karen L. Fearon, Keith Moon, Davida Johnson, Glenn Albrecht, Shujun Luo, Jen-I Mao
Publikováno v:
Nature Biotechnology. 18:630-634
We describe a novel sequencing approach that combines non-gel-based signature sequencing with in vitro cloning of millions of templates on separate 5 microm diameter microbeads. After constructing a microbead library of DNA templates by in vitro clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42a800f1374a578bc3567c890336d2
https://doi.org/10.1038/76469
https://doi.org/10.1038/76469
Publikováno v:
Tetrahedron Letters. 38:207-210
A new method for the synthesis of N3′→P5′ phosphoramidate oligonucleotides is demonstrated. This phosphoramidite amine-exchange method generates cycle yields in the 92–95% range, and provides overall yields that are 3–6 times higher than th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4950cdaee5cd1de4eeb226ccf7997f
https://doi.org/10.1016/s0040-4039(96)02254-x
https://doi.org/10.1016/s0040-4039(96)02254-x
Publikováno v:
The Journal of Organic Chemistry. 60:6998-7005
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2653c1b9ea045911212aabad5235bd5b
https://doi.org/10.1021/jo00126a060
https://doi.org/10.1021/jo00126a060
Publikováno v:
Nucleic Acids Research. 23:2754-2761
Electrospray ionization mass spectrometry (ESI-MS) of reversed-phase HPLC-purified phosphorothioate oligodeoxynucleotides (S-ODNs), and the single-('n - 1') and double-nucleotide deletion ('n - 2') impurities subsequently isolated from them by prepar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67517b54ab1011b54e4a8f9acc37a0f3
https://doi.org/10.1093/nar/23.14.2754
https://doi.org/10.1093/nar/23.14.2754
Autor:
HM Kozy, Edith M. Hessel, Karen L. Fearon, Mark McHale, John D. Campbell, Holger Kanzler, John Bell, Sariah A. Kell, Robert L. Coffman, Mark Graham
Publikováno v:
C21. NEW TARGETS FOR ASTHMA THERAPY.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ae80b7537edf8ff968940733f9c549
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4077
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4077
Autor:
Wojciech J. Stec, B. John Bergot, Bernard L. Hirschbein, Andrzej Wilk, Karen L. Fearon, Bogdan Uznanski
Publikováno v:
Tetrahedron Letters. 34:5317-5320
A new sulfurizing reagent is reported for the automated synthesis of phosphothioate analogues of oligonucloetides via the phosphoramidite method. Bis(O,diisopropoxy phosphinothioyl) disulfide (S-Tetra, 1 ) is relatively inexpensive to prepare, easy t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07bcfaa587f289aa771d478306dc68d
https://doi.org/10.1016/s0040-4039(00)73984-0
https://doi.org/10.1016/s0040-4039(00)73984-0
Publikováno v:
ChemInform. 28
A new method for the synthesis of N3′→P5′ phosphoramidate oligonucleotides is demonstrated. This phosphoramidite amine-exchange method generates cycle yields in the 92–95% range, and provides overall yields that are 3–6 times higher than th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb3a86d945cf8309e73cfd3d46c8d8b
https://doi.org/10.1002/chin.199720196
https://doi.org/10.1002/chin.199720196
Autor:
Karen L. Fearon, Franck J. Barrat, Omar Duramad, Jean H. Chan, Josh Gregorio, Bonnie Chang, Robert L. Coffman
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 174(9)
In parallel with the discovery of the immunostimulatory activities of CpG-containing oligodeoxynucleotides, several groups have reported specific DNA sequences that could inhibit activation by CpG-containing oligodeoxynucleotides in mouse models. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654c678e2a8d8465ce9c91b5ddf5a3b9
https://pubmed.ncbi.nlm.nih.gov/15843514
https://pubmed.ncbi.nlm.nih.gov/15843514
Autor:
Alya Zolotorev, Jennifer O. Lizcano, Kathleen M. Brasky, Hazel M. McClure, Christi Abbate, Karen L. Fearon, Jason Marshall, Robert L. Coffman, Tracy dela Cruz, Debbie Higgins, Priscilla Yee, Holger Kanzler, Edith M. Hessel, Josh Gregorio, Gary Van Nest, Krishna K. Murthy
Publikováno v:
DNA and cell biology. 24(2)
CpG-C are a novel class of CpG motif-containing immunostimulatory sequences (ISS) that includes both a 5'-TCG element and a CpG-containing palindrome. CpG-C drive all known ISS activities and, in particular, are potent enhancers of IFN-alpha from pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c409c6bb41f45c3c72c7b6e54b4a4f
https://pubmed.ncbi.nlm.nih.gov/15699627
https://pubmed.ncbi.nlm.nih.gov/15699627