Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Karen L. Cooper"'
Autor:
Rachel M. Speer, Shuvro P. Nandi, Karen L. Cooper, Xixi Zhou, Hui Yu, Yan Guo, Laurie G. Hudson, Ludmil B. Alexandrov, Ke Jian Liu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Arsenic enhances the carcinogenicity of ultraviolet radiation (UVR). However, the mechanisms of arsenic-driven oncogenesis are not well understood. Here, we utilize experimental systems to investigate the carcinogenic and mutagenic propertie
Externí odkaz:
https://doaj.org/article/f2b3976df61a4e12854326502c2e7c85
Publikováno v:
Toxicology and Applied Pharmacology. 457:116320
Environmental arsenic exposure is associated with lung cancer. Arsenic is the first substance known to cause lung cancer by two distinct routes, ingestion and inhalation, in the forms of soluble arsenite and particulate arsenic trioxide, respectively
Autor:
K J Ke Jian Liu, Dayna Dominguez, Lindsay Volk, Karen L. Cooper, Laurie G. Hudson, Antonia D Duran
Publikováno v:
Toxicol Appl Pharmacol
Arsenic is a naturally occurring element present in food, soil and water and human exposure is associated with increased cancer risk. Arsenic inhibits DNA repair at low, non-cytotoxic concentrations and amplifies the mutagenic and carcinogenic impact
Publikováno v:
Toxicology and Applied Pharmacology. 331:108-115
Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)-1, and inhibits PARP-1 activity in the base excision repair (BER) pathway. PARP inhibition by arsenite enhances ultraviolet radiation (UV
Publikováno v:
Journal of Biological Chemistry. 290:18361-18369
Cysteine oxidation induced by reactive oxygen species (ROS) on redox-sensitive targets such as zinc finger proteins plays a critical role in redox signaling and subsequent biological outcomes. We found that arsenic exposure led to oxidation of certai
Autor:
Ke Jian Liu, Xixi Zhou, Laurie G. Hudson, Karen L. Cooper, Huan Xu, Juliana Huestis, Scott W. Burchiel
Publikováno v:
Oncotarget
// Xixi Zhou 1 , Karen L. Cooper 1 , Juliana Huestis 1 , Huan Xu 1 , Scott W. Burchiel 1 , Laurie G. Hudson 1 , Ke Jian Liu 1 1 Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque,
Autor:
Young Mi Cho, Erica J. Dashner, Ranalda Tsosie, Laurie G. Hudson, Johnnye Lewis, Karen L. Cooper
Publikováno v:
Toxicology and applied pharmacology. 291
Uranium has radiological and non-radiological effects within biological systems and there is increasing evidence for genotoxic and carcinogenic properties attributable to uranium through its heavy metal properties. In this study, we report that low c
Publikováno v:
Arsenic: Exposure Sources, Health Risks, and Mechanisms of Toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c0aef258f41fdd3b7f1fe1698e5fec4
https://doi.org/10.1002/9781118876992.ch13
https://doi.org/10.1002/9781118876992.ch13
Publikováno v:
Journal of Biological Chemistry. 286:22855-22863
Arsenic inhibits DNA repair and enhances the genotoxicity of DNA-damaging agents such as benzo[a]pyrene and ultraviolet radiation. Arsenic interaction with DNA repair proteins containing functional zinc finger motifs is one proposed mechanism to acco
Publikováno v:
Free Radical Biology and Medicine. 47:381-388
Solar ultraviolet radiation (UVR) is the major etiological factor in skin carcinogenesis. However, in vivo studies demonstrate that mice exposed to arsenic and UVR exhibit significantly more tumors and oxidative DNA damage than animals treated with e