Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Karen L. Clark"'
Autor:
Chunrong He, Karen L. Clark, Jian Tan, Hecheng Zhou, Rocky S. Tuan, Hang Lin, Song Wu, Peter G. Alexander
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background Traumatic impacts to the articular joint surface are known to lead to cartilage degeneration, as in post-traumatic osteoarthritis (PTOA). Limited progress in the development of disease-modifying OA drugs (DMOADs) may be due to ins
Externí odkaz:
https://doaj.org/article/88e061e33f8c47b1b7460fb3c3e97d71
Autor:
Shiqi Xiang, Zixuan Lin, Meagan J. Makarcyzk, Kanyakorn Riewruja, Yiqian Zhang, Xiurui Zhang, Zhong Li, Karen L. Clark, Eileen Li, Silvia Liu, Tingjun Hao, Madalyn R. Fritch, Peter G. Alexander, Hang Lin
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)
Abstract Background Human multipotent progenitor cells (hiMPCs) created from induced pluripotent stem cells (iPSCs) represent a new cell source for cartilage regeneration. In most studies, bone morphogenetic proteins (BMPs) are needed to enhance tran
Externí odkaz:
https://doaj.org/article/e8827580f394402bbc112ead85bcb966
Autor:
Xueqi Wang, Yiming Guan, Shiyu Xiang, Karen L. Clark, Peter G. Alexander, Lauren E. Simonian, Yuhao Deng, Hang Lin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In the past 3 decades, the cartilage repair potential of mesenchymal stromal cells, or mesenchymal stem cells (MSCs), has been widely examined in animal studies. Unfortunately, the phenotype and physical properties of MSC-derived cartilage tissue are
Externí odkaz:
https://doaj.org/article/51e762edf08944608ee274ed9f238b3a
Autor:
Alessandro Pirosa, Karen L. Clark, Jian Tan, Shuting Yu, Yuanheng Yang, Rocky S. Tuan, Peter G. Alexander
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Background Animal cell-based systems have been critical tools in understanding tissue development and physiology, but they are less successful in more practical tasks, such as predicting human toxicity to pharmacological or environmental fac
Externí odkaz:
https://doaj.org/article/b952e48a89a64a32b658a26b9bbc9bdb
Publikováno v:
Biology, Vol 11, Iss 7, p 996 (2022)
Osteoarthritis (OA) is a chronic degenerative joint disease that causes pain, physical disability, and life quality impairment. The pathophysiology of OA remains largely unclear, and currently no FDA-approved disease-modifying OA drugs (DMOADs) are a
Externí odkaz:
https://doaj.org/article/5be7227dec844fdcaa7662eca34c49ee
Autor:
Mingsheng Xie, Yiqian Zhang, Zixuan Xiong, Sophie Hines, Jiangyinzi Shang, Karen L. Clark, Susheng Tan, Peter G. Alexander, Hang Lin
Publikováno v:
Acta Biomaterialia. 149:150-166
Chondrocytic hypertrophy, a phenotype not observed in healthy hyaline cartilage, is often concomitant with the chondrogenesis of human mesenchymal stromal cells (hMSCs). This undesired feature represents one of the major obstacles in applying hMSCs f
Autor:
Chunrong He, Karen L. Clark, Jian Tan, Hecheng Zhou, Rocky S. Tuan, Hang Lin, Song Wu, Peter G. Alexander
BackgroundTraumatic impacts to the articular joint surface are known to lead to degeneration of the cartilage, as in post-traumatic osteoarthritis (PTOA). While animal-based systems have been instrumental in understanding pathogenic progression of PT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76b6e5942b45444054fe45ccde1da58
https://doi.org/10.21203/rs.3.rs-1616788/v1
https://doi.org/10.21203/rs.3.rs-1616788/v1
Autor:
Rocky S. Tuan, Jian Tan, Shuting Yu, Peter G. Alexander, Alessandro Pirosa, Karen L. Clark, Yuanheng Yang
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-14 (2019)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Animal cell-based systems have been critical tools in understanding tissue development and physiology, but they are less successful in more practical tasks, such as predicting human toxicity to pharmacological or environmental factors, in
Autor:
Deo Kumar Srivastava, Sara Helmig, Daniel M. Green, Michael W. Bishop, Matthew J. Krasin, Karen L. Clark, Brandon M. Triplett, Gregory T. Armstrong, Kevin R. Krull, Monika L. Metzger, Amar Gajjar, Tara M. Brinkman, Nicole Barnes, Charles A. Sklar, Sujuan Huang, Carmen L. Wilson, Leslie L. Robison, Angela Delaney, Anthony Sheyn, Zhenghong Li, Barry L. Shulkin, Kari L. Bjornard, Wassim Chemaitilly, Melissa M. Hudson, Kristen K Ness, Catherine G. Lam, Rebecca M. Howell, Noah D. Sabin, Ching-Hong Pui
Publikováno v:
Cancer
BACKGROUND Data on primary hypothyroidism and its long-term impact on the health, cognition, and quality of life (QOL) of childhood cancer survivors are limited. This study examined the prevalence of and risk factors for primary hypothyroidism and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d73f2d89577e71a5951ffa0da53e15e
https://europepmc.org/articles/PMC8776571/
https://europepmc.org/articles/PMC8776571/
Autor:
Chelsea Goodliffe Goodenough, Jessica L Baedke, Nan Li, Tara M. Brinkman, Carmen Louise Wilson, Angela M. Delaney, Hiroto Inaba, Karen L Clark, Gregory T. Armstrong, Aimee C. Talleur, Ching-Hon Pui, Daniel M. Green, Thomas E. Merchant, Deo Kumar Srivastava, Yutaka Yasui, Melissa M. Hudson, Leslie L. Robison, Sue C. Kaste, Kirsten K. Ness, Wassim Chemaitilly
Publikováno v:
Journal of Clinical Oncology. 40:e22021-e22021
e22021 Background: Survivors of childhood cancer are at risk for BMD deficits. Contributions of treatment, physical and lifestyle factors to overall risk are unknown as are long-term consequences of moderate and severe deficits. Methods: BMD deficits