Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Karen L. Buchmueller"'
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9774db1163e353e2593fe9b77d7c1d5
https://doi.org/10.1096/fasebj.2018.32.1_supplement.652.8
https://doi.org/10.1096/fasebj.2018.32.1_supplement.652.8
Autor:
W. David Wilson, Caroline O'Hare, Daniel Hochhauser, Zarmeen T. Taherbhai, Moses Lee, Suzanna L. Bailey, Cameron M. Howard, Binh Nguyen, Karen L. Buchmueller, John A. Hartley
Publikováno v:
ChemBioChem. 6:2305-2311
A novel hairpin polyamide, ZT65B, containing a 3-methylpicolinate moiety was designed to target the inverted CCAAT box (ICB) of the human multidrug resistance 1 gene (MDR1) promoter. Binding of nuclear factor-Y (NF-Y) to the ICB site upregulates MDR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5fb3da47fc73615a381bc6efd8c060
https://doi.org/10.1002/cbic.200500179
https://doi.org/10.1002/cbic.200500179
Autor:
Cameron M. Howard, James A. Henry, N. M. Le, Moses Lee, Peter B. Uthe, Suzanna L. Bailey, Karen L. Buchmueller, Andrew M. Staples, Sarah M. Horick, Kari K. Cox
Publikováno v:
Letters in Drug Design & Discovery. 2:137-142
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9079e3506890dc786c6e669b6fb92242
https://doi.org/10.2174/1570180053175160
https://doi.org/10.2174/1570180053175160
Autor:
N. Minh Le, Peter B. Uthe, Andrew M. Staples, Binh Nguyen, Cameron M. Howard, Karen L. Buchmueller, W. David Wilson, Kari K. Cox, Sarah M. Horick, Moses Lee, Kimberly A. O. Pacheco
Publikováno v:
Journal of the American Chemical Society. 127:742-750
Pyrrole (Py) and imidazole (Im) polyamides can be designed to target specific DNA sequences. The effect that the pyrrole and imidazole arrangement, plus DNA sequence, have on sequence specificity and binding affinity has been investigated using DNA m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebba1103ee803acbf10d465e3d758205
https://doi.org/10.1021/ja044359p
https://doi.org/10.1021/ja044359p
Autor:
Cameron M. Howard, Binh Nguyen, Sarah M. Horick, Suzanna L. Bailey, Daniel Hochhauser, N. M. Le, James A. Henry, Moses Lee, Karen L. Buchmueller, Minal Kotecha, John A. Hartley, W. D. Wilson
Publikováno v:
Biochemistry. 43:12249-12257
The topoisomerase IIalpha promoter is regulated through transcription factor interactions with five inverted CCAAT boxes (ICBs). In confluent cancer cells, binding of nuclear factor Y to ICB2 represses the expression of this gene, contributing to res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f216917b89fc1b5101a58f5be28add65
https://doi.org/10.1021/bi048785z
https://doi.org/10.1021/bi048785z
Publikováno v:
Journal of the American Chemical Society. 125:10850-10861
Arylazide mediated photocrosslinking has been widely used to obtain structural constraints in biological systems, even though the reactive species generated upon photolysis in aqueous solution have not been well characterized. We establish a mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74fa8e2f09e809b63f1a9c5479b508f5
https://doi.org/10.1021/ja035743+
https://doi.org/10.1021/ja035743+
Autor:
Karen L. Buchmueller, Austin E. Smith
Publikováno v:
Biochemistry. 50(38)
The molecular mechanism for the displacement of HMGA1 proteins from DNA is integral to disrupting their cellular function, which is linked to many metastatic cancers. Chemical shift and NOESY NMR experiments provide structural evidence for the displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4152cc60f8f0dd3662f6dcfb2e2aaa5a
https://pubmed.ncbi.nlm.nih.gov/21854010
https://pubmed.ncbi.nlm.nih.gov/21854010
Autor:
Karen L. Buchmueller, Caroline O'Hare, David A. Matthews, Zachary S. Davis, Suzanna L. Bailey, Zarmeen T. Taherbhai, Moses Lee, John A. Hartley, Chrystal D. Bruce, Janna K. Register
Publikováno v:
Biochemistry. 45(45)
The polyamide f-ImPyIm has a higher affinity for its cognate DNA than either the parent analogue, distamycin A (10-fold), or the structural isomer, f-PyImIm (250-fold), has for its respective cognate DNA sequence. These findings have led to the formu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b375afce1257057514cc36669bf9f393
https://pubmed.ncbi.nlm.nih.gov/17087509
https://pubmed.ncbi.nlm.nih.gov/17087509
Autor:
Jerome Kluza, John A. Hartley, Caroline O'Hare, Karen L. Buchmueller, Jim S. Sexton, Peter B. Uthe, Daniel Hochhauser, Lloyd V. Flores, Andrew M. Staples, W. David Wilson, Cameron M. Howard, Hilary Mackay, Moses Lee
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(11)
The synthesis and DNA-binding properties of a novel naphthalimide-polyamide hairpin (3) designed to target the inverted CCAAT box 2 (ICB2) site on the topoisomerase IIalpha (topoIIalpha) promoter are described. The polyamide component of 3 was derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f007e35bbd55aed6bb9b9f0ff68032f3
https://pubmed.ncbi.nlm.nih.gov/16991167
https://pubmed.ncbi.nlm.nih.gov/16991167
Autor:
Zarmeen T. Taherbhai, Justin B. Jones, Michelle Stewart, Caroline O'Hare, David Wilson, Toni Brown, Binh Nguyen, Hilary Mackay, Moses Lee, Jerome Kluza, Lindsay Stallings, John A. Hartley, Mark Turlington, Karen L. Buchmueller, Jim S. Sexton, Arden Sutterfield
Publikováno v:
Bioorganicmedicinal chemistry. 15(1)
Five polyamide derivatives with rationally modified C-terminus moieties were synthesized and their DNA binding specificity and affinity determined. A convergent approach was employed to synthesize polyamides containing an alkylaminopiperazine (4 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1f7eed53dc0ac8c39336bba265920c
https://pubmed.ncbi.nlm.nih.gov/17035029
https://pubmed.ncbi.nlm.nih.gov/17035029