Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Karen L Thijssen"'
Autor:
Alba Muniesa-Vargas, Carlota Davó-Martínez, Cristina Ribeiro-Silva, Melanie van der Woude, Karen L. Thijssen, Ben Haspels, David Häckes, Ülkem U. Kaynak, Roland Kanaar, Jurgen A. Marteijn, Arjan F. Theil, Maayke M. P. Kuijten, Wim Vermeulen, Hannes Lans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Congenital nucleotide excision repair (NER) deficiency gives rise to several cancer-prone and/or progeroid disorders. It is not understood how defects in the same DNA repair pathway cause different disease features and severity. Here, we sho
Externí odkaz:
https://doaj.org/article/93db3bf48b4e441887ae6a50279dcc97
Autor:
Karen L. Thijssen, Melanie van der Woude, Carlota Davó-Martínez, Dick H. W. Dekkers, Mariangela Sabatella, Jeroen A. A. Demmers, Wim Vermeulen, Hannes Lans
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Hereditary mutations in TTDA/GTF2H5 cause a photosensitive form of the rare developmental disorder trichothiodystrophy, however the development of models has been hampered by mutations being lethal. Thijssen et al. show that deficiency of C. elegans
Externí odkaz:
https://doaj.org/article/aa9b284b2d79417c957d8200b1542823
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108608- (2021)
Summary: Hereditary DNA repair defects affect tissues differently, suggesting that in vivo cells respond differently to DNA damage. Knowledge of the DNA damage response, however, is largely based on in vitro and cell culture studies, and it is curren
Externí odkaz:
https://doaj.org/article/d1cf96e62a9340c4960315d5a0e55498
Transcription-coupled nucleotide excision repair (TC-NER) is an important DNA repair mechanism that protects against the negative effects of transcription-blocking DNA lesions. Hereditary TC-NER deficiency causes pleiotropic and often severe neurodeg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be216f894d4bc5741d8dea56789a3d69
https://doi.org/10.1101/2023.01.24.525327
https://doi.org/10.1101/2023.01.24.525327
Autor:
Dick H. W. Dekkers, Carlota Davó-Martínez, Karen L. Thijssen, Hannes Lans, Wim Vermeulen, Mariangela Sabatella, Jeroen Demmers, Melanie van der Woude
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology, 4(1):1336. Springer Nature
Communications Biology
Communications Biology, 4(1):1336. Springer Nature
The 10-subunit TFIIH complex is vital to transcription and nucleotide excision repair. Hereditary mutations in its smallest subunit, TTDA/GTF2H5, cause a photosensitive form of the rare developmental disorder trichothiodystrophy. Some trichothiodystr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa5e73a379471a3cb271a6eb2e4d9cb
https://doi.org/10.1038/s42003-021-02875-8
https://doi.org/10.1038/s42003-021-02875-8
Autor:
Melanie van der Woude, Wim Vermeulen, Hannes Lans, Mariangela Sabatella, Karen L. Thijssen, Carlota Davó-Martínez
The 10-subunit TFIIH complex is vital to both transcription initiation and nucleotide excision repair. Hereditary mutations in its smallest subunit, TTDA/GTF2H5, cause a photosensitive form of the rare developmental brittle hair disorder trichothiody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd5d1937f527f7846a97cb787c257fc4
https://doi.org/10.1101/2021.06.04.447037
https://doi.org/10.1101/2021.06.04.447037
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108608-(2021)
Cell Reports, 34(2):108608. Cell Press
Cell Reports, 34(2):108608. Cell Press
Summary Hereditary DNA repair defects affect tissues differently, suggesting that in vivo cells respond differently to DNA damage. Knowledge of the DNA damage response, however, is largely based on in vitro and cell culture studies, and it is current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818324eaf473f81612d0efcbda9ccf88
https://doi.org/10.1016/j.celrep.2020.108608
https://doi.org/10.1016/j.celrep.2020.108608
Autor:
Mariangela Sabatella, Cristina Ribeiro-Silva, Hannes Lans, Karen L. Thijssen, Jana Slyskova, Wim Vermeulen, Chantal Voskamp, Arjan F. Theil
Publikováno v:
Nucleic Acids Research, 46(18), 9563-9577. Oxford University Press
Nucleic Acids Research
Nucleic Acids Research
The structure-specific ERCC1-XPF endonuclease plays a key role in DNA damage excision by nucleotide excision repair (NER) and interstrand crosslink repair. Mutations in this complex can either cause xeroderma pigmentosum (XP) or XP combined with Cock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ab43ed6abe5c130821d2eb9f83619d
https://doi.org/10.1093/nar/gky774
https://doi.org/10.1093/nar/gky774
Autor:
Tjakko J van Ham, Karen L Thijssen, Rainer Breitling, Robert M W Hofstra, Ronald H A Plasterk, Ellen A A Nollen
Publikováno v:
PLoS Genetics, Vol 4, Iss 3, p e1000027 (2008)
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood. We have developed a C. elegans model that makes it possib
Externí odkaz:
https://doaj.org/article/050d2ba5bb134ce5934a470417bc3c73
Autor:
Hannes Lans, Petra Schwertman, Karen L. Thijssen, Nikoline Borgermann, Leena Ackermann, Niels Mailand, Julio C Y Liu, Ivo A. Hendriks, Michael L. Nielsen
Publikováno v:
Borgermann, N, Ackermann, L, Schwertman, P, Hendriks, I A, Thijssen, K, Liu, J C, Lans, H, Nielsen, M L & Mailand, N 2019, ' SUMOylation promotes protective responses to DNA-protein crosslinks ', E M B O Journal, vol. 38, e101496 . https://doi.org/10.15252/embj.2019101496
The EMBO Journal
EMBO Journal, 38(8):e101496. Wiley-Blackwell
The EMBO Journal
EMBO Journal, 38(8):e101496. Wiley-Blackwell
DNA‐protein crosslinks (DPCs) are highly cytotoxic lesions that obstruct essential DNA transactions and whose resolution is critical for cell and organismal fitness. However, the mechanisms by which cells respond to and overcome DPCs remain incompl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a2bbe01a2ad9d894ceeb591134ad99
https://curis.ku.dk/portal/da/publications/sumoylation-promotes-protective-responses-to-dnaprotein-crosslinks(b11db8db-def5-41da-b302-7aa5faa4f775).html
https://curis.ku.dk/portal/da/publications/sumoylation-promotes-protective-responses-to-dnaprotein-crosslinks(b11db8db-def5-41da-b302-7aa5faa4f775).html