Výsledky vyhledávání - "Karen L Denzler"

Akademický článek

Use of a recombinant vaccinia virus expressing interferon gamma for post-exposure protection against vaccinia and ectromelia viruses.

Autor: Susan A Holechek, Karen L Denzler, Michael C Heck, Jill Schriewer, R Mark Buller, Fatema A Legrand, Paulo H Verardi, Leslie A Jones, Tilahun Yilma, Bertram L Jacobs

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77879 (2013)

Post-exposure vaccination with vaccinia virus (VACV) has been suggested to be effective in minimizing death if administered within four days of smallpox exposure. While there is anecdotal evidence for efficacy of post-exposure vaccination this has no

Externí odkaz: https://doaj.org/article/299781d8cc654d19aee1cd1f56066d3e

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Akademický článek

In vitro characterization of a nineteenth-century therapy for smallpox.

Autor: William Arndt, Chandra Mitnik, Karen L Denzler, Stacy White, Robert Waters, Bertram L Jacobs, Yvan Rochon, Victoria A Olson, Inger K Damon, Jeffrey O Langland

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32610 (2012)

In the nineteenth century, smallpox ravaged through the United States and Canada. At this time, a botanical preparation, derived from the carnivorous plant Sarracenia purpurea, was proclaimed as being a successful therapy for smallpox infections. The

Externí odkaz: https://doaj.org/article/593adf58d9ea417ba9b2f4985eddd56d

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Akademický článek

Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals.

Autor: Karen L Denzler, Robert Waters, Bertram L Jacobs, Yvan Rochon, Jeffrey O Langland

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12561 (2010)

Many hundreds of botanicals are used in complementary and alternative medicine for therapeutic use as antimicrobials and immune stimulators. While there exists many centuries of anecdotal evidence and few clinical studies on the activity and efficacy

Externí odkaz: https://doaj.org/article/740b1e4250eb4c1abb4ea85095672266

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The attenuated NYCBH vaccinia virus deleted for the immune evasion gene, E3L, completely protects mice against heterologous challenge with ectromelia virus

Autor: Bertram L. Jacobs, Jill Schriewer, Chas Werner, Scott Parker, Trung Huynh, Susan A. Holechek, Karen L. Denzler, Ed Hembrador, Hollyce Hartzler, R. M. L. Buller

Publikováno v: Vaccine. 29:9691-9696

The New York City Board of Health (NYCBH) vaccinia virus (VACV) vaccine strain was deleted for the immune evasion gene, E3L, and tested for its pathogenicity and ability to protect mice from heterologous challenge with ectromelia virus (ECTV). NYCBH�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b40d8a3c8d4151bef98435d4cbc887
https://doi.org/10.1016/j.vaccine.2011.09.108

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The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus

Autor: Brandi R. Manning, Andrew M. Burrage, Richard W. Moyer, Daniele M. Swetnam, Amanda D. Rice, Amy L. MacNeill, Andrew J. Smith, Stacey A. Gray, Karen L. Denzler, Scott F. Lindsey, Greg Wallace, Bertram L. Jacobs, Nobuko Fukushima

Publikováno v: Vaccine. 29:7659-7669

Vaccinia virus deleted for the innate immune evasion gene, E3L, has been shown to be highly attenuated and yet induces a protective immune response against challenge by homologous virus in a mouse model. In this manuscript the NYCBH vaccinia virus va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d67ef4533dca73ebd64ed58c4275b5c
https://doi.org/10.1016/j.vaccine.2011.07.140

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Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene

Autor: Karen L. Denzler, Enzo Paoletti, Bertram L. Jacobs, Elizabeth Beattie, Marion E. Perkus, James Tartaglia

Publikováno v: Journal of Virology. 69:499-505

The vaccinia virus (VV) E3L gene, which encodes a potent inhibitor of the interferon (IFN)-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is thought to be involved in the IFN-resistant phenotype of VV. The E3L gene products, p25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3a1895cef76a9b9501d6a8fa3c0202
https://doi.org/10.1128/jvi.69.1.499-505.1995

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In vitro characterization of a nineteenth-century therapy for smallpox

Autor: Inger K. Damon, Jeffrey Langland, Chandra Mitnik, Bertram L. Jacobs, Victoria A. Olson, Yvan Rochon, Karen L. Denzler, William D. Arndt, Robert Waters, Stacy D. White

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32610 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0730d55606c36170183d08ff4eb85cca
http://europepmc.org/articles/PMC3302891?pdf=render

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Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation

Autor: G Cieslewicz, Karen L. Denzler, J. P. Justice, K. A. Lindenberger, James J. Lee, W. Wu, Stephania A. Cormier, E.M. Hines, Michael T. Borchers, Gerald J. Gleich, Nancy A. Lee, Jeffrey R. Crosby, Stanley A Hazen, W. Song

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 167(3)

Paradigms of eosinophil effector function in the lungs of asthma patients invariably depend on activities mediated by cationic proteins released from secondary granules during a process collectively referred to as degranulation. In this study, we gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae9b36a9c6f5b78b73c70e312ade0ef
https://pubmed.ncbi.nlm.nih.gov/11466391

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Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma

Autor: Jeffrey R. Crosby, Michael T. Borchers, Kirsten A. Larson, Stephania Cormier-Regard, G Cieslewicz, Karen L. Denzler, James J. Lee, S. Farmer, Nancy A. Lee

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 165(10)

The relationship between eosinophils and the development of Ag-induced pulmonary pathologies, including airway hyper-responsiveness, was investigated using mice deficient for the secondary granule component, major basic protein-1 (mMBP-1). The loss o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65750b6808588d0a6252f3a48afe6265
https://pubmed.ncbi.nlm.nih.gov/11067904

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Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma

Autor: Erwin W. Gelfand, Margaret A. Horton, Kirsten A. Larson, Patricia E. Carrigan, George D. Leikauf, Michael P. McGarry, S. Farmer, James J. Lee, Karen L. Denzler, I Brenneise, Nancy A. Lee, Angela Franciska Haczku

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol 185, iss 12
Scopus-Elsevier
The Journal of experimental medicine, vol 185, iss 12

We have generated transgenic mice that constitutively express murine interleukin (IL)-5 in the lung epithelium. Airway expression of this cytokine resulted in a dramatic accumulation of peribronchial eosinophils and striking pathologic changes includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612acadc937b297c99e51f908fcdebc5
https://pubmed.ncbi.nlm.nih.gov/9182686

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