Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karen L Chu"'
Autor:
Assen Roguev, Russell M Gordley, Timothy K Lu, Nicholas W Frankel, Ippolito I Caradonna, Tony Hua, Kanya Rajangam, Karen L Chu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/ae17988081314233b8d563f323c381ac
Autor:
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L. Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y. Q. Han, Aspen J. Pierson, Michael Xiao, Xuejing Yang, Lindsey M. Kuehm, Yuning Hong, Diu T. T. Nguyen, Gabriela Chiosis, Alex Kentsis, Christina Leslie, Ly P. Vu, Michael G. Kharas
Publikováno v:
Nature Communications. 14
Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantation. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2661985f06dc2fb83dc34d021c9531d
https://doi.org/10.1038/s41467-023-38001-x
https://doi.org/10.1038/s41467-023-38001-x
Autor:
Tatiana Erazo, Chiara M. Evans, Daniel Zakheim, Karen L. Chu, Alice Yunsi Refermat, Zahra Asgari, Xuejing Yang, Mariana Da Silva Ferreira, Sanjoy Mehta, Marco Vincenzo Russo, Andrea Knezevic, Xi-Ping Zhang, Zhengming Chen, Myles Fennell, Ralph Garippa, Venkatraman Seshan, Elisa de Stanchina, Olena Barbash, Connie Lee Batlevi, Christina S. Leslie, Ari M. Melnick, Anas Younes, Michael G. Kharas
Publikováno v:
Nature communications. 13(1)
To identify drivers of sensitivity and resistance to Protein Arginine Methyltransferase 5 (PRMT5) inhibition, we perform a genome-wide CRISPR/Cas9 screen. We identify TP53 and RNA-binding protein MUSASHI2 (MSI2) as the top-ranked sensitizer and drive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7e429b6aac6d3fecd6a10f5b0a27b5
https://pubmed.ncbi.nlm.nih.gov/36167829
https://pubmed.ncbi.nlm.nih.gov/36167829
Autor:
Ersilia Barin, Diu Tt. Nguyen, Karen L. Chu, Anthony Velleca, Dinshaw J. Patel, Thomas M. Rohwetter, Samie R. Jaffrey, Brian F. Pickering, Michael G. Kharas, Hanzhi Luo, Xuejing Yang, Shanlan Mo, Yuanming Cheng, Angela M. Savino, Wei Xie
Publikováno v:
Cancer Cell
N(6)-methyladenosine (m(6)A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m(6)A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bd5141c70092b5481649d6ec888bb4
https://pubmed.ncbi.nlm.nih.gov/34079105
https://pubmed.ncbi.nlm.nih.gov/34079105
Autor:
Yuheng Lu, Saroj Gourkanti, Ly P. Vu, Alexandra Schurer, Christina S. Leslie, Payal Patel, Diu T.T. Nguyen, Sun Mi Park, Ersilia Barin, Christopher R. Chin, Camila Prieto, Angela M. Savino, Zi-ning Choo, Michael G. Kharas, Karen L. Chu, Xuejing Yang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a Drosophila RNA editing enzyme (ADAR) to globally map the mRNA targets of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a22606bbf12defd779927ca8a17bddf
https://doi.org/10.1038/s41467-020-15814-8
https://doi.org/10.1038/s41467-020-15814-8
Autor:
Hanzhi Luo, Diu T.T. Nguyen, Paolo Cifani, Karen L Chu, Alex Kentsis, Ersilia Barin, Florisela Herrejon Chavez, Christina S. Leslie, Alexandra Schurer, Ly P. Vu, Alli Pine, Michael G. Kharas
Publikováno v:
Blood. 138:296-296
RNA binding proteins (RBPs) have been increasingly recognized as an important class of regulators of normal and malignant hematopoiesis. However, the exact function and underpinning mechanisms of the RBPs that govern hematopoietic stem cells (HSCs) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2490f8b739bc5441a9a963de11d38d0d
https://doi.org/10.1182/blood-2021-147575
https://doi.org/10.1182/blood-2021-147575
Autor:
Alice Yunsi Refermat, Olena Barbash, Connie Lee Batlevi, Michael G. Kharas, Ingrid Tatiana Erazo, Karen L Chu, Anas Younes, Daniel Zakheim, Chiara M Evans
Publikováno v:
Blood. 138:788-788
PRMT5 catalyzes the arginine symmetric demethylation of histone and non-histone proteins. PRMT5 is overexpressed in lymphoma and plays a key role in lymphomagenesis through the repression of several tumor suppressors, including P53, while promoting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8e6cfa9412f0ceee41d09e8d91b099
https://doi.org/10.1182/blood-2021-151280
https://doi.org/10.1182/blood-2021-151280
Autor:
Josef Leibold, Januka Budhathoki-Uprety, Michelle R. Neiman, Vinagolu K. Rajasekhar, Ramya Sridharan, Yosi Shamay, James L. Sugarman, Daniel Roxbury, Janki Shah, Emily Baut, Megan M. Dacek, John D. Chodera, Karen L. Chu, Kripa S. Ganesh, Mehtap Işık, Darjus F. Tschaharganeh, Aviram Mizrachi, Darren C. Johnson, Scott W. Lowe, Daniel A. Heller, Karla Nawaly
Publikováno v:
Nature materials
Development of targeted nanoparticle drug carriers often requires complex synthetic schemes involving both supramolecular self-assembly and chemical modification. These processes are generally difficult to predict, execute, and control. We describe h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5267dd2cbd5618b2b767b4bbcd9d16e
https://pubmed.ncbi.nlm.nih.gov/29860981
https://pubmed.ncbi.nlm.nih.gov/29860981