Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Karen L, de Mesy Bentley"'
Autor:
Harsimran Kaur, Karen L. de Mesy Bentley, Syed Minhaj Rahman, Philip R. Cohen, Bruce R. Smoller
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 5, Pp 1359-1366 (2024)
Abstract Basal cell carcinoma (BCC) is the most common skin cancer. Skin cancers may present either as a non-invasive tumor or an invasive malignancy. The terminology of carcinoma in situ is used when the tumor is either just limited to epidermis or
Externí odkaz:
https://doaj.org/article/766e0aa16ac647e884d1828b484201fd
Autor:
Hakjoo Lee, Tae Jin Lee, Chad A. Galloway, Wenbo Zhi, Wei Xiao, Karen L. de Mesy Bentley, Ashok Sharma, Yong Teng, Hiromi Sesaki, Yisang Yoon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping. Disruption of OPA1 causes mi
Externí odkaz:
https://doaj.org/article/b617f78a85774a2f8dbd285387323e58
Autor:
Youliang Ren, Jason Weeks, Thomas Xue, Joshua Rainbolt, Karen L. de Mesy Bentley, Ye Shu, Yuting Liu, Elysia Masters, Philip Cherian, Charles E. McKenna, Jeffrey Neighbors, Frank H. Ebetino, Edward M. Schwarz, Shuting Sun, Chao Xie
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate-conjugated sitafloxacin (BCS, BV600072) and hydroxybisphosphonate-conjugate sitafloxacin (HBCS, BV63072), which achiev
Externí odkaz:
https://doaj.org/article/96b573a5a803436d94a93195b6f70cb2
Autor:
Gisela Beutner, Jonathan Ryan Burris, Michael P. Collins, Chaitanya A. Kulkarni, Sergiy M. Nadtochiy, Karen L. de Mesy Bentley, Ethan D. Cohen, Paul S. Brookes, George A. Porter, Jr.
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109157- (2024)
Summary: In the embryonic heart, the activation of the mitochondrial electron transport chain (ETC) coincides with the closure of the cyclophilin D (CypD) regulated mitochondrial permeability transition pore (mPTP). However, it remains to be establis
Externí odkaz:
https://doaj.org/article/a462e368f5ea459999c5d9156d652a7f
Autor:
Yue Peng, H. Mark Kenney, Karen L. de Mesy Bentley, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectiveInflammatory-erosive arthritis is exacerbated by dysfunction of joint-draining popliteal lymphatic vessels (PLVs). Synovial mast cells are known to be pro-inflammatory in rheumatoid arthritis (RA). In other settings they have anti-inflammato
Externí odkaz:
https://doaj.org/article/80288ec9980c44ea93b144bd10879db1
Autor:
Yugo Morita, Motoo Saito, Javier Rangel-Moreno, Anthony M. Franchini, John R. Owen, John C. Martinez, John L. Daiss, Karen L. de Mesy Bentley, Stephen L. Kates, Edward M. Schwarz, Gowrishankar Muthukrishnan
Publikováno v:
Bone Research, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial, and its role in patients with S. aureus osteomyelitis is unknown. To address this knowledge gap, we completed a clinical study and obs
Externí odkaz:
https://doaj.org/article/225a91035f104c71992dd36009af973e
Autor:
Humberto Mestre, Natasha Verma, Thom D. Greene, LiJing A. Lin, Antonio Ladron-de-Guevara, Amanda M. Sweeney, Guojun Liu, V. Kaye Thomas, Chad A. Galloway, Karen L. de Mesy Bentley, Maiken Nedergaard, Rupal I. Mehta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The precise boundaries and flow compartments of perivascular spaces in the brain are incompletely understood. Here the authors show that pia is perforated and permissive to CSF flow, forming three types of perivascular spaces that remodel with age, w
Externí odkaz:
https://doaj.org/article/cbaee97b65ea484ba67afb890df054ca
Autor:
Youliang Ren, Thomas Xue, Joshua Rainbolt, Karen L. de Mesy Bentley, Chad A. Galloway, Yuting Liu, Philip Cherian, Jeffrey Neighbors, Marloes I. Hofstee, Frank H. Ebetino, Thomas Fintan Moriarty, Shuting Sun, Edward M. Schwarz, Chao Xie
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
S. aureus infection of bone is difficult to eradicate due to its ability to colonize the osteocyte-lacuno-canalicular network (OLCN), rendering it resistant to standard-of-care (SOC) antibiotics. To overcome this, we proposed two bone-targeted bispho
Externí odkaz:
https://doaj.org/article/bce85e9c2bad40a79c4e87db39e8c0b8
Autor:
Edward M. Schwarz, H. Mark Kenney, Yue Peng, Karen L. de Mesy Bentley, Lianping Xing, Christopher T. Ritchlin
Publikováno v:
Current Rheumatology Reviews. 19:246-259
Abstract: Lymphatic muscle cell (LMC) contractility and coverage of collecting lymphatic vessels (CLVs) are integral to effective lymphatic drainage and tissue homeostasis. In fact, defects in lym-phatic contractility have been identified in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d629644d2823bc9c2eab598fcbe081
https://doi.org/10.2174/1573397119666230127144711
https://doi.org/10.2174/1573397119666230127144711
Autor:
Elysia A. Masters, Gowrishankar Muthukrishnan, Lananh Ho, Ann Lindley Gill, Karen L. de Mesy Bentley, Chad A. Galloway, James L. McGrath, Hani A. Awad, Steven R. Gill, Edward M. Schwarz
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network (OLCN) is a novel mechanism of bacterial persistence and immune evasion in chronic osteomyelitis. Previous work highlighted S. aureus cell wall transpeptidase, penicillin bind
Externí odkaz:
https://doaj.org/article/9f13972546dd407aa4bcffa9929fcc8f