Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Karen Kodys"'
Autor:
Shashi Bala, Charles D. Calenda, Donna Catalano, Mrigya Babuta, Karen Kodys, Imad A. Nasser, Barbara Vidal, Gyongyi Szabo
Publikováno v:
Hepatology Communications, Vol 4, Iss 10, Pp 1487-1501 (2020)
Acute liver injury (ALI) is associated with multiple cellular events such as necrosis, apoptosis, oxidative stress and inflammation, which can lead to liver failure. In this study, we demonstrate a new role of microRNA (miR)‐208a in ALI. ALI was in
Externí odkaz:
https://doaj.org/article/3cf286f7709b4b0ba4c58bc3421dfce7
Autor:
Arvin Iracheta‐Vellve, Charles D. Calenda, Jan Petrasek, Aditya Ambade, Karen Kodys, Luciano Adorini, Gyongyi Szabo
Publikováno v:
Hepatology Communications, Vol 2, Iss 11, Pp 1379-1391 (2018)
Bile acids (BAs) activate various dedicated receptors, including the farnesoid X receptor (FXR) and the Takeda G protein‐coupled receptor 5 (TGR5). The FXR agonist obeticholic acid (OCA) is licensed for the treatment of primary biliary cholangitis
Externí odkaz:
https://doaj.org/article/6c2110584eaa40cbad2d3993d5dd9b6c
Autor:
Patrick P Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Yeonhee Cho, Karen Kodys, Donna Catalano, Doyle V Ward, Gyongyi Szabo
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0179070 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0174544.].
Externí odkaz:
https://doaj.org/article/d5e971afce2d4f5a84b23cd9af17fd98
Autor:
Patrick P Lowe, Benedek Gyongyosi, Abhishek Satishchandran, Arvin Iracheta-Vellve, Aditya Ambade, Karen Kodys, Donna Catalano, Doyle V Ward, Gyongyi Szabo
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174544 (2017)
BACKGROUND:Alcohol-induced intestinal dysbiosis disrupts homeostatic gut-liver axis function and is essential in the development of alcoholic liver disease. Here, we investigate changes in enteric microbiome composition in a model of early alcoholic
Externí odkaz:
https://doaj.org/article/e8267ff85c15479c817e9cfebfbf9c79
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 3, Pp 302-316.e8 (2016)
Background & Aims: Monocyte and macrophage (MΦ) activation contributes to the pathogenesis of chronic hepatitis C virus (HCV) infection. Disease pathogenesis is regulated by both liver-resident MΦs and monocytes recruited as precursors of MΦ
Externí odkaz:
https://doaj.org/article/3980dabc85594346a58195a9e0a5c630
Autor:
Timea Csak, Shashi Bala, Dora Lippai, Karen Kodys, Donna Catalano, Arvin Iracheta-Vellve, Gyongyi Szabo
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129251 (2015)
BACKGROUND & AIM:MicroRNAs (miRs) regulate hepatic steatosis, inflammation and fibrosis. Fibrosis is the consequence of chronic tissue damage and inflammation. We hypothesized that deficiency of miR-155, a master regulator of inflammation, attenuates
Externí odkaz:
https://doaj.org/article/2e9862b706f34a89966c6dcb5b994a70
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004424 (2014)
Antibodies targeting receptor-mediated entry of HCV into hepatocytes confer limited therapeutic benefits. Evidence suggests that exosomes can transfer genetic materials between cells; however, their role in HCV infection remains obscure. Here, we sho
Externí odkaz:
https://doaj.org/article/b9447af51d464fa08a4d4b37543b21f1
Autor:
Angela Dolganiuc, Karen Kodys, Christopher Marshall, Banishree Saha, Shuye Zhang, Shashi Bala, Gyongyi Szabo
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e44915 (2012)
BACKGROUND & AIMS:Hepatitis C virus (HCV) is difficult to eradicate and type III interferons (IFN-λ, composed of IL-28A, IL-28B and IL-29) are novel therapeutic candidates. We hypothesized that IFN-λ have immunomodulatory effects in HCV- infected i
Externí odkaz:
https://doaj.org/article/c2cfd18739c54fea9deefac1f3567e0a
Autor:
Charles D. Calenda, Shashi Bala, Mrigya Babuta, Gyongyi Szabo, Donna Catalano, Imad A. Nasser, Karen Kodys, Barbara Vidal
Publikováno v:
Hepatology Communications, Vol 4, Iss 10, Pp 1487-1501 (2020)
Hepatology Communications
Hepatology Communications
Acute liver injury (ALI) is associated with multiple cellular events such as necrosis, apoptosis, oxidative stress and inflammation, which can lead to liver failure. In this study, we demonstrate a new role of microRNA (miR)‐208a in ALI. ALI was in
Autor:
Shashi Bala, Charles D. Calenda, Terence N. Bukong, Istvan Furi, Patrick Lowe, Gyongyi Szabo, Donna Catalano, Karen Kodys, Mrigya Babuta
Publikováno v:
Hepatology
Cellular homeostais, that is normally maintained through autophagy, is disrupted in alcoholic liver disease (ALD). Because autophagy and exosome biogenesis share common elements, we hypothesized that increased exosome production in ALD may be linked