Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Karen Kage"'
Autor:
Govindi J. Samaranayake, Clara I. Troccoli, Mai Huynh, Rolando D. Z. Lyles, Karen Kage, Andrew Win, Vishalakshi Lakshmanan, Deukwoo Kwon, Yuguang Ban, Steven Xi Chen, Enrique Rodriguez Zarco, Merce Jorda, Kerry L. Burnstein, Priyamvada Rai
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Identifying actionable components in castration–resistant prostate cancer (CRPC) is critical for the development of effective treatments. Here, the authors show that the inhibition of the redox-protective protein TRX1 decreases the growth of CRPC c
Externí odkaz:
https://doaj.org/article/d2ca0dbfe1e54bac82aeb4b72d117967
Autor:
Victoria E. Scott, Mulugeta Mamo, Russell A. Judge, Connie R. Faltynek, C. Brent Putman, Ana L. Aguirre, Marian Namovic, Vincent S. Stoll, Karen Kage, Steven Cassar, Adrian D. Hobson, Janel M. Boyce-Rustay, Steve D. Pratt, Anil Vasudevan, Steven Swann, Gricelda H. Simler
Publikováno v:
ChemBioChem. 19:613-621
We describe the design, synthesis, and structure-activity relationships (SARs) of a series of 2-aminobenzothiazole inhibitors of Rho kinases (ROCKs) 1 and 2, which were optimized to low nanomolar potencies by use of protein kinase A (PKA) as a struct
Autor:
Clara I. Troccoli, Andrew Win, Kerry L. Burnstein, Rolando D. Z. Lyles, Merce Jorda, Priyamvada Rai, Steven Xi Chen, Vishalakshi Lakshmanan, Karen Kage, Mai Huynh, Govindi J. Samaranayake, Enrique Rodriguez Zarco, Deukwoo Kwon, Yuguang Ban
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
Androgen deprivation (AD) therapy failure leads to terminal and incurable castration-resistant prostate cancer (CRPC). We show that the redox-protective protein thioredoxin-1 (TRX1) increases with prostate cancer progression and in androgen-deprived
Autor:
Andrew O. Stewart, Janel M. Boyce-Rustay, Ivan Milicic, Chang Z. Zhu, Jill M. Wetter, Timothy A. Vortherms, Michael F. Jarvis, Marian T. Namovic, Diana L. Donnelly-Roberts, Chengmin Zhong, Victoria E. Scott, Karen Kage, Rodger F. Henry, Erica Gomez, Scott J. Baker, Carol S. Surowy, Daria Darczak, Pamela H. Franklin, Gricelda H. Simler, Wende Niforatos, Richard S. Janis, Andrew M. Swensen, Kennan C. Marsh, Xenia Beebe
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:4128-4139
A novel 4-aminocyclopentapyrrolidine series of N-type Ca(2+) channel blockers have been discovered. Enantioselective synthesis of the 4-aminocyclopentapyrrolidines was enabled using N-tert-butyl sulfinamide chemistry. SAR studies demonstrate selectiv
Autor:
Joseph P. Mikusa, Prisca Honore, Gricelda Hernandez, Karen Kage, Wende Niforatos, Char-Chang Shieh, Torben R. Neelands, Michael F. Jarvis, S.K. Joshi, Xu-Feng Zhang, Ping Han, Connie R. Faltynek, James P. Sullivan, Scott J. Baker, Douglas S. Krafte
Publikováno v:
Pain. 123:75-82
Antisense (AS) oligodeoxynucleotides (ODNs) targeting the Nav 1.8 sodium channel have been reported to decrease inflammatory hyperalgesia and L5/L6 spinal nerve ligation-induced mechanical allodynia in rats. The present studies were conducted to furt
Autor:
Karen Kage, Clara I. Troccoli, Kerry L. Burnstein, Xi Chen, Mai Q. Huynh, Priyamvada Rai, Merce Jorda, Yuguang Ban, Enrique Rodriguez Zarco, Deukwoo Kwon, Govindi J. Samaranayake
Publikováno v:
Cancer Research. 77:5479-5479
Androgen deprivation therapy (ADT) initially suppresses prostate cancer (PC) progression. However, castration resistant PC (CRPC) cells inevitably emerge, resulting in incurable disease. We recently demonstrated that AD produces a form of cellular se
Autor:
Karen Kage, Elizabeth A. Kowaluk, Edward Touma, Edward C. Burgard, Tim van Biesen, Kevin J. Lynch, Michael F. Jarvis, Wende Niforatos
Publikováno v:
Molecular Pharmacology. 58:1502-1510
TNP-ATP has become widely recognized as a potent and selective P2X receptor antagonist, and is currently being used to discriminate between subtypes of P2X receptors in a variety of tissues. We have investigated the ability of TNP-ATP to inhibit alph
Autor:
Wende Niforatos, Edward C. Burgard, Kevin J. Lynch, Michael F. Jarvis, Edward Touma, van Biesen T, Elizabeth A. Kowaluk, Karen Kage
Publikováno v:
Molecular Pharmacology. 56:1171-1181
P2X receptors are a family of ATP-gated ion channels. Four cDNAs with a high degree of homology to the rat P2X(2) receptor were isolated from human pituitary and pancreas RNA. Genomic sequence indicated that these cDNAs represent alternatively splice
Publikováno v:
The Journal of Experimental Medicine
Immunoglobulin (Ig) genes expressed in mature B lymphocytes can undergo somatic hypermutation upon cell interaction with antigen and T cells. The mutation mechanism had previously been shown to depend upon transcription initiation, suggesting that a
Publikováno v:
Journal of Molecular Evolution. 36:255-262
The turkey metallothionein gene (tkMT) was isolated from a phage lambda-turkey genomic DNA library by virtue of high identity with chicken MT cDNA. The nucleotide sequences of the proximal 240 by of the 5′-flanking region, of each of the three exon