Výsledky vyhledávání - "Karen K. Hsiao"

Akademický článek

Glutamate Receptor Dysregulation in the Hippocampus of Transgenic Mice Carrying Mutated Human Amyloid Precursor Protein

Autor: Jang-Ho J. Cha, Laurie A. Farrell, Sharlin F. Ahmed, Ariel Frey, Karen K. Hsiao-Ashe, Anne B. Young, John B. Penney, Joseph J. Locascio, Bradley T. Hyman, Michael C. Irizarry

Publikováno v: Neurobiology of Disease, Vol 8, Iss 1, Pp 90-102 (2001)

Alzheimer's disease transgenic mice overexpressing human amyloid precursor protein (hAPP) with the Swedish double mutation (hAPPSw) develop age-related amyloid deposition and behavioral and electrophysiologic changes by an unknown mechanism. Analysis

Externí odkaz: https://doaj.org/article/babb4efcb4bc48839621d2214e488582

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Glutamate Receptor Dysregulation in the Hippocampus of Transgenic Mice Carrying Mutated Human Amyloid Precursor Protein

Autor: Laurie A. Farrell, Karen K. Hsiao-Ashe, Jang Ho J. Cha, Joseph J. Locascio, Bradley T. Hyman, Anne B. Young, Ariel S. Frey, Michael C. Irizarry, John B. Penney, Sharlin F. Ahmed

Publikováno v: Neurobiology of Disease, Vol 8, Iss 1, Pp 90-102 (2001)

Alzheimer's disease transgenic mice overexpressing human amyloid precursor protein (hAPP) with the Swedish double mutation (hAPP(Sw)) develop age-related amyloid deposition and behavioral and electrophysiologic changes by an unknown mechanism. Analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a0760aafdfd17ab96810eb69b46a10
https://doi.org/10.1006/nbdi.2000.0330

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Caveolin-3 Upregulation Activates β-Secretase–Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer’s Disease

Autor: Takeshi Iwatsubo, Richard M. Ransohoff, Taisuke Tomita, Bruce D. Trapp, Michael P. Lisanti, Ichiro Kanazawa, Tsuneya Ikezu, Karen K. Hsiao, Takashi Okamoto, Kazutoshi Nishiyama

Publikováno v: The Journal of Neuroscience. 19:6538-6548

Here, we investigate the involvement of caveolins in the pathophysiology of Alzheimer’s disease (AD). We show dramatic upregulation of caveolin-3 immunoreactivity in astroglial cells surrounding senile plaques in brain tissue sections from authenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435e1bde6f34087736322e6cc6c192b5
https://doi.org/10.1523/jneurosci.19-15-06538.1999

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SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

Autor: Costantino Iadecola, Elizabeth R. Fischer, David R. Borchelt, George A. Carlson, Kiyoshi Niwa, Sherry Turner, Karen K. Hsiao, Fangyi Zhang, Chris Eckman, Steven G. Younkin

Publikováno v: Nature Neuroscience. 2:157-161

Peptides derived from proteolytic processing of the beta-amyloid precursor protein (APP), including the amyloid-beta peptide, are important for the pathogenesis of Alzheimer's dementia. We found that transgenic mice overexpressing APP have a profound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327b8b3e04849ad2586ed3274141ae51
https://doi.org/10.1038/5715

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Autor: Wael S. Yunis, David R. Borchelt, Donald L. Price, Steven G. Younkin, Sherry Xu, Costantino Iadecola, George A. Carlson, Chris Eckman, Rosa Johannsdottir, H. Brent Clark, Kristine Olson, Cheryl Kitt, Karen K. Hsiao

Publikováno v: Neuron. 15(5):1203-1218

Transgenic FVB/N mice overexpressing human (Hu) or mouse (Mo) Alzheimer amyloid precursor protein (APP695) die early and develop a CNS disorder that includes neophobia and impaired spatial alternation, with diminished glucose utilization and astrogli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185ef63de8681c29deff5e302e3c236d

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Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein

Autor: Stanley B. Prusiner, John Collinge, Dallas Foster, Karen K. Hsiao, Stephen J. DeArmond, Katie C. L. Sidle, Marilyn Torchia, Michael R. Scott, Glenn C. Telling, Shu Lian Yang

Publikováno v: Proceedings of the National Academy of Sciences. 91:9936-9940

Transgenic (Tg) mice were constructed that express a chimeric prion protein (PrP) in which a segment of mouse (Mo) PrP was replaced with the corresponding human (Hu) PrP sequence. The chimeric PrP, designated MHu2MPrP, differs from MoPrP by 9 amino a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56970235b80503616ff46ac12337a04e
https://doi.org/10.1073/pnas.91.21.9936

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Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein

Autor: Dallas Foster, Shu Lian Yang, Darlene Groth, Stephen J. DeArmond, Dennis Rapp, Marilyn Torchia, Michael R. Scott, Karen K. Hsiao, Hana Serban, Stanley B. Prusiner

Publikováno v: Proceedings of the National Academy of Sciences. 91:9126-9130

Two lines of transgenic (Tg) mice expressing high (H) levels of the mutant P101L prion protein (PrP) developed a neurologic illness and central nervous system pathology indistinguishable from experimental murine scrapie; these mice were designated Tg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd1d9b2f5102d10db6c23c398c90cf3
https://doi.org/10.1073/pnas.91.19.9126

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Human prion diseases

Autor: Karen K. Hsiao, Stanley B. Prusiner

Publikováno v: Principles and Practice of Clinical Virology, Fourth Edition

The prion diseases, sometimes referred to as the "transmissible spongiform encephalopathies," include kuru, Creutzfeldt-Jakob disease, and Gerstmann-Sträussler-Scheinker disease of humans as well as scrapie and bovine spongiform encephalopathy of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb9450e101db9a376f74115b5684734
https://doi.org/10.1002/ana.410350404

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