Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Karen Jo Doyle"'
Publikováno v:
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 116(6)
A study was performed to investigate the relationship between external and middle ear factors and hearing screening results by auditory brain stem response (ABR) and transient evoked otoacoustic emissions (EOAEs). The ears of 200 well newborns aged 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183a172c813b2f6b634fddb086b4296c
https://pubmed.ncbi.nlm.nih.gov/29389264
https://pubmed.ncbi.nlm.nih.gov/29389264
Autor:
Hong-Gang Wang, Nipavan Chiamvimonvat, Michael Anne Gratton, Jeong-Han Lee, Atefeh Mousavi-Nik, Wenying Wang, Xiao-Dong Zhang, Ebenezer N. Yamoah, Karen Jo Doyle, Hyo Jeong Kim, Somayeh Fathabad Gharaie, Choong Ryoul Sihn, Ping Lv
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 34, iss 21
Spiral ganglion neurons (SGNs) of the eighth nerve serve as the bridge between hair cells and the cochlear nucleus. Hair cells use Cav1.3 as the primary channel for Ca2+inflow to mediate transmitter release. In contrast, SGNs are equipped with multip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dfcebf8c5e62c3c07727fed7331603
https://doi.org/10.1523/jneurosci.5416-13.2014
https://doi.org/10.1523/jneurosci.5416-13.2014
Autor:
Xiaojing Wang, Anthony E. Pegg, Michael Anne Gratton, Ebenezer N. Yamoah, Karen Jo Doyle, Snezana Levic
Publikováno v:
Journal of Biological Chemistry. 284:930-937
Male gyro (Gy) mice, which have an X chromosomal deletion inactivating the SpmS and Phex genes, were found to be profoundly hearing impaired. This defect was due to alteration in polyamine content due to the absence of spermine synthase, the product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba885af45c5100e9bf51f51a6b53623b
https://doi.org/10.1074/jbc.m807758200
https://doi.org/10.1074/jbc.m807758200
Autor:
Jerry B. Lingrel, Gary E. Shull, Emma Lou Cardell, Dongguang Wei, Rodney C. Diaz, Ebenezer N. Yamoah, Karen Jo Doyle, Hongwei Dou, Ana E. Vázquez
Publikováno v:
Journal of the Association for Research in Otolaryngology. 8:422-434
Although drug-induced and age-related hearing losses are frequent otologic problems affecting millions of people, their underlying mechanisms remain uncertain. The inner ear is exclusively endowed with a positive endocochlear potential (EP) that serv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d9fbc1c1ba207cee85e72e964094d9
https://doi.org/10.1007/s10162-007-0089-4
https://doi.org/10.1007/s10162-007-0089-4
Autor:
Karen Jo Doyle, Xiao-Dong Zhang, Yinuo Zhang, Wenying Wang, Ebenezer N. Yamoah, Nipavan Chiamvimonvat, Choong Ryoul Sihn, Maria Cristina Perez Flores, Hyo Jeong Kim
Publikováno v:
The Journal of General Physiology
A glutamate at position 290 in the human Kv7.1 S5-pore linker is required for its inhibition by high concentrations of extracellular potassium.
Kv7.1 voltage-gated K+ (Kv) channels are present in the apical membranes of marginal cells of the str
Kv7.1 voltage-gated K+ (Kv) channels are present in the apical membranes of marginal cells of the str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7871eab7c52da576baf3ede33f9f4e48
https://pubmed.ncbi.nlm.nih.gov/25712016
https://pubmed.ncbi.nlm.nih.gov/25712016
Autor:
Jason R. Rock, Jeong-Han Lee, Wei Chun Chen, Wenying Wang, Dongguang Wei, Ebenezer N. Yamoah, Ping Lv, Karen Jo Doyle, Xiao-Dong Zhang, Choong Ryoul Sihn, Nipavan Chiamvimonvat, Hyo Jeong Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(8)
The developmental rehearsal for the debut of hearing is marked by massive changes in the membrane properties of hair cells (HCs) and spiral ganglion neurons (SGNs). Whereas the underlying mechanisms for the developing HC transition to mature stage ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c3aadcb95dfe7217bbc72b41f339a5
https://pubmed.ncbi.nlm.nih.gov/25675481
https://pubmed.ncbi.nlm.nih.gov/25675481
Autor:
Rodney C. Diaz, Karen Jo Doyle, Michael Anne Gratton, Ebenezer N. Yamoah, Weihong Feng, Liping Nie
Publikováno v:
Journal of Biological Chemistry. 280:15097-15102
l-α-Difluoromethylornithine (DFMO) is a chemopreventive agent for colon cancer in clinical trials. Yet, the drug produces an across-frequency elevation of the hearing threshold, suggesting that DFMO may affect a common trait along the cochlear spira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6151c12f5e5ccd880080aefaa8c10560
https://doi.org/10.1074/jbc.m409856200
https://doi.org/10.1074/jbc.m409856200
Autor:
R. Mark Ray, Karen Jo Doyle
Publikováno v:
Mental Retardation and Developmental Disabilities Research Reviews. 9:94-102
This article reviews the role of the otolaryngologist-head and neck surgeon-in the diagnosis and treatment of hearing loss in infants and young children. The otolaryngologist is well-versed in the anatomy, physiology, and pathophysiology of the audit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d28ff132b2c523ffdf1710b387af19
https://doi.org/10.1002/mrdd.10065
https://doi.org/10.1002/mrdd.10065
Autor:
Victor Wong, Hyo Jeong Kim, Maria Cristina Perez Flores, Atefeh Mousavi-Nik, Jeong-Han Lee, Wenying Wang, Ebenezer N. Yamoah, Ping Lv, Yanfang Xu, Choong Ryoul Sihn, Karen Jo Doyle
Publikováno v:
The Journal of biological chemistry. 289(24)
The KCNE3 β-subunit interacts with and regulates the voltage-dependent gating, kinetics, and pharmacology of a variety of Kv channels in neurons. Because a single neuron may express multiple KCNE3 partners, it is impossible to predict the overall fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3ac987942a97a87dbbbb81912832e5
https://pubmed.ncbi.nlm.nih.gov/24727472
https://pubmed.ncbi.nlm.nih.gov/24727472
Autor:
Karen Jo Doyle
Publikováno v:
The Laryngoscope. 111:781-785
Objectives/Hypothesis Difluoromethylornithine (DFMO) is an anticancer experimental drug that is ototoxic. The objectives of these three experiments were to: 1) determine a dose and dosing schedule of DFMO that produces significant hearing loss (HL) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce08489eda86fe5391c2943fd57d87ad
https://doi.org/10.1097/00005537-200105000-00005
https://doi.org/10.1097/00005537-200105000-00005