Reversible modulation of SIRT1 activity in a mouse strain.

Autor: Katherine V Clark-Knowles, Xiaohong He, Karen Jardine, Josée Coulombe, Danielle Dewar-Darch, Annabelle Z Caron, Douglas A Gray, Michael W McBurney

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173002 (2017)

The SIRT1 protein deacetylase is reported to have a remarkably wide spectrum of biological functions affecting such varied processes as aging, cancer, metabolism, neurodegeneration and immunity. However, the SIRT1 literature is also full of contradic

Externí odkaz: https://doaj.org/article/eea5c16680974a76a38d73f40805ccdc

SirT1 regulates energy metabolism and response to caloric restriction in mice.

Autor: Gino Boily, Erin L Seifert, Lisa Bevilacqua, Xiao Hong He, Guillaume Sabourin, Carmen Estey, Cynthia Moffat, Sean Crawford, Sarah Saliba, Karen Jardine, Jian Xuan, Meredith Evans, Mary-Ellen Harper, Michael W McBurney

Publikováno v: PLoS ONE, Vol 3, Iss 3, p e1759 (2008)

The yeast sir2 gene and its orthologues in Drosophila and C. elegans have well-established roles in lifespan determination and response to caloric restriction. We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2

Externí odkaz: https://doaj.org/article/36211b3cbf8640b68ee1e68fd53ddffb

Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma

Autor: Alexander Gont, Danny Jomaa, Karen Jardine, Ian A. J. Lorimer, Sylvie J. Lavictoire, David P. Cook

Publikováno v: The Journal of Biological Chemistry

The protein Lgl1 is a key regulator of cell polarity. We previously showed that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN tumour suppressor loss and aberrant activation of the PI 3-kinase pathway; this contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eac172f9342d10d751e70e28529ec91
http://europepmc.org/articles/PMC8551657

IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation

Autor: David A. Patten, Céline Aguer, Marc Foretz, Léa Garneau, Lucien Nadeau, Le Bris S. Quinn, E.E. Pistilli, Michael W. McBurney, Barbara G. Anderson, P. Haddad, Audrey Caron, Mary-Ellen Harper, E. Pinault-Masson, Karen Jardine

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2019, 1863 (2), pp.395-407. ⟨10.1016/j.bbagen.2018.10.021⟩

Background IL-15 is believed to play a role in the beneficial impact of exercise on muscle energy metabolism. However, previous studies have generally used supraphysiological levels of IL-15 that do not represent contraction-induced IL-15 secretion.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5465d0c40d36258a8c1390cbf83742b
https://doi.org/10.1016/j.bbagen.2018.10.021

CSIG-12. PREX1 LINKS ABERRANT PI 3-KINASE PATHWAY SIGNALING TO MAINTENANCE OF THE NEURAL STEM CELL-LIKE PHENOTYPE OF GLIOBLASTOMA CELLS

Autor: Danny Jomaa, Ian A. J. Lorimer, Sylvie J. Lavictoire, Alex Gont, Karen Jardine

Publikováno v: Neuro Oncol

Virtually all primary glioblastomas have aberrant activation of the PI 3-kinase pathway through mutational inactivation of tumour suppressors such as PTEN and/or mutational activation of oncogenes. Most glioblastomas also overexpress the Rac guanine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58fbf7fa7b1aff836443145562a44d2
https://europepmc.org/articles/PMC6847169/