Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Karen J. Wong"'
Autor:
Elaine M. Jagoda, Sibaprasad Bhattacharyya, Joseph Kalen, Lisa Riffle, Avrum Leeder, Stephanie Histed, Mark Williams, Karen J. Wong, Biying Xu, Lawrence P. Szajek, Osama Elbuluk, Fabiola Cecchi, Kristen Raffensperger, Meghana Golla, Donald P. Bottaro, Peter Choyke
Publikováno v:
Molecular Imaging, Vol 14 (2015)
Developing an imaging agent targeting the hepatocyte growth factor receptor protein (Met) status of cancerous lesions would aid in the diagnosis and monitoring of Met-targeted tyrosine kinase inhibitors (TKIS). A peptide targeting Met labeled with [
Externí odkaz:
https://doaj.org/article/b4b698de7cb6463c8bfdf88a43f902f0
Autor:
J. Seidel, M.V. Green, Karen J. Wong, Mark R. Williams, Anita Ton, Elaine M. Jagoda, Peter L. Choyke, Falguni Basuli
Publikováno v:
Nuclear Medicine and Biology. 53:29-36
Introduction Quantitative small animal radionuclide imaging studies are often carried out with the intention of estimating the total radioactivity content of various tissues such as the radioactivity content of mouse xenograft tumors exposed to putat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d7d8c957f799354d8e356364330e99
https://doi.org/10.1016/j.nucmedbio.2017.06.004
https://doi.org/10.1016/j.nucmedbio.2017.06.004
Autor:
Karen J. Wong, J Lee, William D. Figg, D. E. Milenic, Yolanda Y. McKinney, Stephen Adler, Esther Mena, Shivaani Kummar, P. L. Choyke, S Lipkowitz, Baris Turkbey, Maria Merino, Liza Lindenberg, James H. Doroshow, C H Paik, Tristan M. Sissung, Karen A. Kurdziel, Martin W. Brechbiel
Publikováno v:
Journal of translational science
Introduction Tumors over-expressing the human epithelial receptor 2 (HER2) or exhibiting amplification or mutation of its proto-oncogene have a poorer prognosis. Using trastuzumab and/or other HER2 targeted therapies can increase overall survival in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7744afaff9573707c5b87bb8705e6696
http://europepmc.org/articles/PMC6425962
http://europepmc.org/articles/PMC6425962
Autor:
Diane E. Milenic, Kwamena E. Baidoo, Karen J. Wong, Jose Delgado, Martin W. Brechbiel, Young-Seung Kim, Rachel Barkley
Refinement of treatment regimens enlisting targeted α-radiation therapy (TAT) is an ongoing effort. Among the variables to consider are the target molecule, radionuclide, dosage, and administration route. The panitumumab F(ab′)(2) fragment targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c088936ed8d33731236484e95a1122d1
https://europepmc.org/articles/PMC6011368/
https://europepmc.org/articles/PMC6011368/
Autor:
J. Seidel, Peter L. Choyke, Marcelino Bernardo, Changhui Li, Biying Xu, Karen J. Wong, M.V. Green, Gary L. Griffiths, Falguni Basuli, Elaine M. Jagoda, Mark R. Williams, Frank Kuo
Publikováno v:
Nuclear Medicine and Biology. 41:582-586
Introduction We describe and illustrate a method for creating ECG-gated PET images of the heart for each of several mice imaged at the same time. The method is intended to increase “throughput” in PET research studies of cardiac dynamics or to ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f343241610012cd29a65feeaf0bfbf
https://doi.org/10.1016/j.nucmedbio.2014.03.015
https://doi.org/10.1016/j.nucmedbio.2014.03.015
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 28:441-449
The studies described herein assess the potential of combining platinum-based chemotherapy with high-linear energy transfer (LET) α-particle-targeted radiation therapy using trastuzumab as the delivery vehicle. An initial study explored the combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f0642ea1405c2d6dd34d74c2a9881f
https://doi.org/10.1089/cbr.2012.1423
https://doi.org/10.1089/cbr.2012.1423
Autor:
Diane E. Milenic, Tapan K. Nayak, Martin W. Brechbiel, Karen J. Wong, Celeste A. S. Regino, Kwamena E. Baidoo, Kayhan Garmestani
Publikováno v:
mAbs. 2:550-564
The potential of the HER2-targeting antibody trastuzumab as a radioimmunoconjugate useful for both imaging and therapy was investigated. Conjugation of trastuzumab with the acyclic bifunctional chelator CHX-A"-DTPA yielded a chelate:protein ratio of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a089794fe90252e21468aa8a3d066d07
https://doi.org/10.4161/mabs.2.5.13054
https://doi.org/10.4161/mabs.2.5.13054
Autor:
Michael Williams, Kayhan Garmestani, Geoffrey L. Ray, Martin W. Brechbiel, Diane E. Milenic, Kwamena E. Baidoo, Karen J. Wong
Publikováno v:
British Journal of Pharmacology. 157:1541-1548
The studies described here are the first to evaluate the in vitro and in vivo properties of (111)In-CHX-A''-panitumumab for radioimmunotherapy (alpha- and beta(-)-emitters) and radioimmunoimaging (single photon emission computed tomography and positr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8a1612a44853e5b9ae5868d69c0a01
https://doi.org/10.1111/j.1476-5381.2009.00327.x
https://doi.org/10.1111/j.1476-5381.2009.00327.x
Autor:
Peter Eck, Peter L. Choyke, Celeste A. S. Regino, Marcelino Bernardo, Karen J. Wong, Diane E. Milenic, C. A. Boswell, Martin W. Brechbiel
Publikováno v:
Molecular Pharmaceutics. 5:527-539
Ligand size and valency strongly influence the receptor uptake and clearance of tumor angiogenesis imaging agents. The structures of successful imaging agents exhibit a high degree of variability, encompassing small monovalent arginine-glycine-aspart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1477a19c1fa96bdcd6cc83c426489a4
https://doi.org/10.1021/mp800022a
https://doi.org/10.1021/mp800022a
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2679-2683
The use of monoclonal antibodies (mAbs) as targeting vectors to selectively deliver a lethal dose of radiation to cancer cells through either a β- or α-emitting radionuclide, radioimmunotherapy (RIT), has been extensively investigated for cancer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1f96a0b0aa0e94e72a15229db056a8
https://doi.org/10.1016/j.bmcl.2008.03.022
https://doi.org/10.1016/j.bmcl.2008.03.022