Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Karen J. Scott"'
Autor:
Louise M. E. Müller, Matthew Holmes, Joanne L. Michael, Gina B. Scott, Emma J. West, Karen J. Scott, Christopher Parrish, Kathryn Hall, Sina Stäble, Victoria A. Jennings, Matthew Cullen, Stewart McConnell, Catherine Langton, Emma L. Tidswell, Darren Shafren, Adel Samson, Kevin J. Harrington, Hardev Pandha, Christy Ralph, Richard J. Kelly, Gordon Cook, Alan A. Melcher, Fiona Errington-Mais
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Background The oncolytic virus, coxsackievirus A21 (CVA21), has shown promise as a single agent in several clinical trials and is now being tested in combination with immune checkpoint blockade. Combination therapies offer the best chance of
Externí odkaz:
https://doaj.org/article/45333d28906e4c79a697ecb02c401857
Autor:
Julia V. Cockle, Anke Brüning-Richardson, Karen J. Scott, Jill Thompson, Timothy Kottke, Ewan Morrison, Azam Ismail, Angel M. Carcaboso, Ailsa Rose, Peter Selby, Joe Conner, Susan Picton, Susan Short, Richard Vile, Alan Melcher, Elizabeth Ilett
Publikováno v:
Molecular Therapy: Oncolytics, Vol 5, Iss C, Pp 75-86 (2017)
Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms.
Externí odkaz:
https://doaj.org/article/6daa5830e2af4d63a0235f4c00e305f7
Autor:
Samantha Turnbull, Emma J. West, Karen J. Scott, Elizabeth Appleton, Alan Melcher, Christy Ralph
Publikováno v:
Viruses, Vol 7, Iss 12, Pp 6291-6312 (2015)
The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in ani
Externí odkaz:
https://doaj.org/article/3696656bf094438d87d6887fd4f64d83
Autor:
Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, Adel Samson
Supplementary Figure from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a91d9095b10d23365f7a59df1819f1
https://doi.org/10.1158/2326-6066.22544210.v1
https://doi.org/10.1158/2326-6066.22544210.v1
Autor:
Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, Adel Samson
Supplementary Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7c77efbfb3b8e77a0ae08974c11a08
https://doi.org/10.1158/2326-6066.22544216.v1
https://doi.org/10.1158/2326-6066.22544216.v1
Autor:
Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, Adel Samson
Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd6fa47fd5f357dfeeffbe9b9017d6b
https://doi.org/10.1158/2326-6066.c.6550577
https://doi.org/10.1158/2326-6066.c.6550577
Autor:
Rebecca C. Auer, Alan A. Melcher, Andrew P. Makrigiannis, John C. Bell, Subash Sad, Ahmad B. Mahmoud, Robert A. Adair, Shalini Sahi, Anu Abhirami Ananth, Almohanad A. Alkayyal, Christiano Tanese de Souza, Karen J. Scott, Jiqing Zhang, Lee-Hwa Tai
PDF file, 190K, Prophylactic vaccines enhance NK cell cytotoxicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd2ecf72f6d2e8f4b3672afbaa82b70
https://doi.org/10.1158/1078-0432.22451886
https://doi.org/10.1158/1078-0432.22451886
Autor:
Rebecca C. Auer, Alan A. Melcher, Andrew P. Makrigiannis, John C. Bell, Subash Sad, Ahmad B. Mahmoud, Robert A. Adair, Shalini Sahi, Anu Abhirami Ananth, Almohanad A. Alkayyal, Christiano Tanese de Souza, Karen J. Scott, Jiqing Zhang, Lee-Hwa Tai
Purpose: Surgical removal of solid primary tumors is an essential component of cancer treatment. Surgery-induced dysfunction in natural killer (NK) cells has been linked to the development of metastases in animal models and patients with cancer. We i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e858fa2ed114bec6445f697ff799a3
https://doi.org/10.1158/1078-0432.c.6522318.v1
https://doi.org/10.1158/1078-0432.c.6522318.v1
Autor:
Adel Samson, Emma J. West, Jonathan Carmichael, Karen J. Scott, Samantha Turnbull, Bethany Kuszlewicz, Rajiv V. Dave, Adam Peckham-Cooper, Emma Tidswell, Jennifer Kingston, Michelle Johnpulle, Barbara da Silva, Victoria A. Jennings, Kaidre Bendjama, Nicolas Stojkowitz, Monika Lusky, K.R. Prasad, Giles J. Toogood, Rebecca Auer, John Bell, Chris J. Twelves, Kevin J. Harrington, Richard G. Vile, Hardev Pandha, Fiona Errington-Mais, Christy Ralph, Darren J. Newton, Alan Anthoney, Alan A. Melcher, Fiona Collinson
Publikováno v:
Cancer Immunology Research. 10:745-756
Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950f3f33403d7506d7775a2e7565c5f9
https://doi.org/10.1158/2326-6066.cir-21-0171
https://doi.org/10.1158/2326-6066.cir-21-0171
Autor:
Emma J. West, Karen J. Scott, Emma Tidswell, Kaidre Bendjama, Nicolas Stojkowitz, Monika Lusky, Marta Kurzawa, Raj Prasad, Giles Toogood, Christy Ralph, D. Alan Anthoney, Alan A. Melcher, Fiona J. Collinson, Adel Samson
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2181
Pexa-Vec is an engineered Wyeth-strain vaccinia oncolytic virus (OV), which has been tested extensively in clinical trials, demonstrating enhanced cytotoxic T cell infiltration into tumours following treatment. Favourable immune consequences to Pexa-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a47e4c44c3476b7e8e33d29ab98aa2
https://pubmed.ncbi.nlm.nih.gov/35565310
https://pubmed.ncbi.nlm.nih.gov/35565310