Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Karen J. Keeran"'
Autor:
Mehdi Pirooznia, Komudi Singh, Marjan Gucek, Danielle A. Springer, Matthew E. Cockman, Angel Aponte, Junhui Sun, Karen J. Keeran, Elizabeth Murphy, Michael Harris, Leslie Kennedy
Publikováno v:
Cardiovasc Res
AIMS Prolyl hydroxylation is a post-translational modification that regulates protein stability, turnover, and activity. The proteins that catalyze prolyl hydroxylation belong to the 2-oxoglutarate- and iron-dependent oxygenase family of proteins. 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42258a3dd425a7f6131f663c403b455
https://pubmed.ncbi.nlm.nih.gov/34668514
https://pubmed.ncbi.nlm.nih.gov/34668514
Autor:
Karin Fredriksson, Jill A Fielhaber, Jonathan K Lam, Xianglan Yao, Katharine S Meyer, Karen J Keeran, Gayle J Zywicke, Xuan Qu, Zu-Xi Yu, Joel Moss, Arnold S Kristof, Stewart J Levine
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e33984 (2012)
The mammalian target of rapamycin (mTOR) modulates immune responses and cellular proliferation. The objective of this study was to assess whether inhibition of mTOR with rapamycin modifies disease severity in two experimental murine models of house d
Externí odkaz:
https://doaj.org/article/fe03ae8f94ab41ce89c3a47ab2dbd0b5
Autor:
Maryann Kaler, Xianglan Yao, Stewart J. Levine, Angel Aponte, Kenneth R. Jeffries, Marjan Gucek, Xuan Qu, Katharine S. Meyer, Rosemarie A. Cuento, Elizabeth M. Gordon, Karen J. Keeran, McCoy Jp, Gayle Z. Nugent, Amisha V. Barochia, Pradeep K. Dagur, Zu-Xi Yu, Cuilian Dai
Publikováno v:
Mucosal immunology
CD163 is a macrophage scavenger receptor with anti-inflammatory and pro-inflammatory functions. Here, we report that alveolar macrophages (AMΦs) from asthmatic subjects had reduced cell-surface expression of CD163, which suggested that CD163 might m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7b8afbe28c705fe976f2bd64bd1003
https://doi.org/10.1038/mi.2015.94
https://doi.org/10.1038/mi.2015.94
Autor:
Kenneth R. Jeffries, Shawn Kozlov, Joni Taylor, Karen J. Keeran, Arthur D. Zetts, Timothy Hunt
Publikováno v:
Journal of Visualized Experiments : JoVE
Cardiovascular disease remains the number one cause of mortality in the United States. There are numerous approaches to treating these diseases, but regardless of the approach, an in vivo model is needed to test each treatment. The pig is one of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7064b59f7d92ccab64c13216922db9
https://doi.org/10.3791/56190
https://doi.org/10.3791/56190
Autor:
Zu-Xi Yu, Xuan Qu, Ankit Saxena, Kenneth R. Jeffries, Amarjit Mishra, Elizabeth M. Gordon, Stewart J. Levine, Amisha V. Barochia, Pradeep K. Dagur, Maryann Kaler, Rosemarie A. Cuento, Xianglan Yao, J. Philip McCoy, Karen J. Keeran
Publikováno v:
The Journal of allergy and clinical immunology. 142(4)
Background Low-density lipoprotein receptor–related protein 1 (LRP-1) is a scavenger receptor that regulates adaptive immunity and inflammation. LRP-1 is not known to modulate the pathogenesis of allergic asthma. Objective We sought to assess wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6804509ba045888e2cdc902ee0ce6a
https://pubmed.ncbi.nlm.nih.gov/29274414
https://pubmed.ncbi.nlm.nih.gov/29274414
Autor:
Xianglan Yao, Meixia Gao, Cuilian Dai, Brenner T, Stewart J. Levine, Xuan Qu, Karen J. Keeran, Zu-Xi Yu, McCoy Jp, Gayle Z. Nugent, Pradeep K. Dagur, Vaisman B, Alan T. Remaley, Katharine S. Meyer
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 51:626-636
Apolipoprotein A-I (apoA-I) is an important component of high-density lipoprotein particles that mediates reverse cholesterol transport out of cells by interacting with the ATP-binding cassette transporter 1 (ABCA1). apoA-I has also been shown to att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ea25c6fbdbb2a0768fd9b4873a542a
https://doi.org/10.1165/rcmb.2013-0264oc
https://doi.org/10.1165/rcmb.2013-0264oc
Autor:
William B. Karkowsky, Or Kalchiem-Dekel, Meixia Gao, Haitao Xu, Amisha V. Barochia, Elizabeth M. Gordon, Stewart J. Levine, Karen J. Keeran, Kenneth R. Jeffries, Maryann Kaler, Xianglan Yao
Publikováno v:
Journal of Allergy and Clinical Immunology. 144:426-441.e3
Background House dust mite (HDM)–challenged Apoe−/− mice display enhanced airway hyperreactivity and mucous cell metaplasia. Objective We sought to characterize the pathways that induce apolipoprotein E (APOE) expression by bronchoalveolar lava
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd88ed077dfbb648805365cb4e8f51b4
https://doi.org/10.1016/j.jaci.2019.02.027
https://doi.org/10.1016/j.jaci.2019.02.027
Autor:
Meixia Gao, Zu-Xi Yu, Xuan Qu, Katharine S. Meyer, Xianglan Yao, Jichun Chen, Cuilian Dai, Stewart J. Levine, Pradeep K. Dagur, Gayle Z. Nugent, Karen J. Keeran, J. Philip McCoy
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:902-911
Peptidoglycan recognition protein (Pglyrp) 1 is a pattern-recognition protein that mediates antibacterial host defense. Because we had previously shown that Pglyrp1 expression is increased in the lungs of house dust mite (HDM)-challenged mice, we hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebfc73fae4370d9a75e873548ff3902
https://doi.org/10.1165/rcmb.2013-0001oc
https://doi.org/10.1165/rcmb.2013-0001oc
Autor:
Cuilian Dai, Xianglan Yao, J. Philip McCoy, Pradeep K. Dagur, Xuan Qu, Stewart J. Levine, Zu-Xi Yu, Gayle J. Zywicke, Karen J. Keeran, Alan T. Remaley
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 47:186-195
Apolipoprotein A-I (apoA-I) is a key component of high-density lipoproteins that mediates reverse cholesterol transport from cells and reduces vascular inflammation. We investigated whether endogenous apoA-I modulates ovalbumin (OVA)-induced airway i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca24341b16c0e103897834265f012320
https://doi.org/10.1165/rcmb.2011-0322oc
https://doi.org/10.1165/rcmb.2011-0322oc
Autor:
Danielle Spinger, Sotirios K. Karathanasis, Jill Walker, Karen J. Keeran, Zu-Xi Yu, Weidong Hao, Audrey Noguchi, Jane K. Osbourn, Michele D. Allen, Natasha Fillmore, Elizabeth Murphy, Junhui Sun, Clevenger Randy
Publikováno v:
Journal of Molecular and Cellular Cardiology. 124:94
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b544de6fb434f9d402b8036e0ac2d47
https://doi.org/10.1016/j.yjmcc.2018.07.039
https://doi.org/10.1016/j.yjmcc.2018.07.039