Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karen J. Billington"'
Autor:
Damer P Blake, Karen J Billington, Susan L Copestake, Richard D Oakes, Michael A Quail, Kiew-Lian Wan, Martin W Shirley, Adrian L Smith
Publikováno v:
PLoS Pathogens, Vol 7, Iss 2, p e1001279 (2011)
Apicomplexan parasites are responsible for a myriad of diseases in humans and livestock; yet despite intensive effort, development of effective sub-unit vaccines remains a long-term goal. Antigenic complexity and our inability to identify protective
Externí odkaz:
https://doaj.org/article/3ab785188f584c3283c7712427409ba3
Autor:
Virginia Marugán-Hernández, Karen J. Billington, Sungwon Kim, Damer P. Blake, Janene M. Bumstead, David J. P. Ferguson, Iván Pastor-Fernández, Lonneke Vervelde, Fiona M. Tomley, Tatiana Küster
Publikováno v:
International Journal for Parasitology
Pastor-Fernández, I, Kim, S, Billington, K, Bumstead, J, Marugán-Hernández, V, Küster, T, Ferguson, D J P, Vervelde, L, Blake, D P & Tomley, F M 2018, ' Development of cross-protective Eimeria-vectored vaccines based on apical membrane antigens ', International Journal For Parasitology . https://doi.org/10.1016/j.ijpara.2018.01.003
Pastor-Fernández, I, Kim, S, Billington, K, Bumstead, J, Marugán-Hernández, V, Küster, T, Ferguson, D J P, Vervelde, L, Blake, D P & Tomley, F M 2018, ' Development of cross-protective Eimeria-vectored vaccines based on apical membrane antigens ', International Journal For Parasitology . https://doi.org/10.1016/j.ijpara.2018.01.003
Recently, the availability of protocols supporting genetic complementation of Eimeria has raised the prospect of generating transgenic parasite lines which can function as vaccine vectors, expressing and delivering heterologous proteins. Complementat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581af99f715c86c077f97cc01f005cf7
https://researchonline.rvc.ac.uk/id/eprint/11244/1/11244.pdf
https://researchonline.rvc.ac.uk/id/eprint/11244/1/11244.pdf
Autor:
Ahmad Fuad Hilmi Mohamad, Adrian Smith, Mohd Rashdi Mohd-Amin, Halimah Alias, Mohd Noor Mat-Isa, Damer P. Blake, Karen J. Billington, Yea Ling Tay, Fiona M. Tomley, Emily L. Clark, Kiew Lian Wan
Publikováno v:
Molecular and Biochemical Parasitology. 184:48-51
Apicomplexan parasites are serious pathogens of animals and man that cause diseases including coccidiosis, malaria and toxoplasmosis. The importance of these parasites has prompted the establishment of genomic resources in support of developing effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69be3623450618905eea8fda31513046
https://doi.org/10.1016/j.molbiopara.2012.03.004
https://doi.org/10.1016/j.molbiopara.2012.03.004
Autor:
Marie-Adèle Rajandream, Mandy Sanders, Matthew Berriman, Alejandro Sanchez-Flores, Tobias Mourier, Alasdair Ivens, Fumiya Kawahara, Damer P. Blake, Kiew-Lan Wan, Hifzur Rahman Ansari, Thomas D. Otto, John Parkinson, Adam J. Reid, Neil D. Rawlings, M W Shirley, Stacy S. Hung, Bart Barrell, Xikun Wu, Mridul Nair, Diego Miranda-Saavedra, Arthur Gruber, Yong H. Woo, Tareq B. Malas, Pierre Rivailler, Fiona M. Tomley, Yea-Ling Tay, Matthew Dunn, Christian Doerig, Josephine M. Bryant, Karen J. Billington, Chandra Subramaniam, Hardeep Naghra, Paul H. Dear, Hilary P. Browne, Arnab Pain
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Reid, A J, Blake, D P, Ansari, H R, Billington, K, Browne, H P, Bryant, J, Dunn, M, Hung, S S, Kawahara, F, Miranda-Saavedra, D, Malas, T B, Mourier, T, Naghra, H, Nair, M, Otto, T D, Rawlings, N D, Rivailler, P, Sanchez-Flores, A, Sanders, M, Subramaniam, C, Tay, Y-L, Woo, Y, Wu, X, Barrell, B, Dear, P H, Doerig, C, Gruber, A, Ivens, A C, Parkinson, J, Rajandream, M-A, Shirley, M W, Wan, K-L, Berriman, M, Tomley, F M & Pain, A 2014, ' Genomic analysis of the causative agents of coccidiosis in domestic chickens ', Genome Research, vol. 24, pp. 1676-1685 . https://doi.org/10.1101/gr.168955.113
Genome Research
Reid, A J, Blake, D P, Ansari, H R, Billington, K, Browne, H P, Bryant, J, Dunn, M, Hung, S S, Kawahara, F, Miranda-Saavedra, D, Malas, T B, Mourier, T, Naghra, H, Nair, M, Otto, T D, Rawlings, N D, Rivailler, P, Sanchez-Flores, A, Sanders, M, Subramaniam, C, Tay, Y L, Woo, Y, Wu, X, Barrell, B, Dear, P H, Doerig, C, Gruber, A, Ivens, A C, Parkinson, J, Rajandream, M A, Shirley, M W, Wan, K L, Berriman, M, Tomley, F M & Pain, A 2014, ' Genomic analysis of the causative agents of coccidiosis in domestic chickens ', Genome Research, vol. 24, no. 10, pp. 1676-1685 . https://doi.org/10.1101/gr.168955.113
Universidade de São Paulo (USP)
instacron:USP
Reid, A J, Blake, D P, Ansari, H R, Billington, K, Browne, H P, Bryant, J, Dunn, M, Hung, S S, Kawahara, F, Miranda-Saavedra, D, Malas, T B, Mourier, T, Naghra, H, Nair, M, Otto, T D, Rawlings, N D, Rivailler, P, Sanchez-Flores, A, Sanders, M, Subramaniam, C, Tay, Y-L, Woo, Y, Wu, X, Barrell, B, Dear, P H, Doerig, C, Gruber, A, Ivens, A C, Parkinson, J, Rajandream, M-A, Shirley, M W, Wan, K-L, Berriman, M, Tomley, F M & Pain, A 2014, ' Genomic analysis of the causative agents of coccidiosis in domestic chickens ', Genome Research, vol. 24, pp. 1676-1685 . https://doi.org/10.1101/gr.168955.113
Genome Research
Reid, A J, Blake, D P, Ansari, H R, Billington, K, Browne, H P, Bryant, J, Dunn, M, Hung, S S, Kawahara, F, Miranda-Saavedra, D, Malas, T B, Mourier, T, Naghra, H, Nair, M, Otto, T D, Rawlings, N D, Rivailler, P, Sanchez-Flores, A, Sanders, M, Subramaniam, C, Tay, Y L, Woo, Y, Wu, X, Barrell, B, Dear, P H, Doerig, C, Gruber, A, Ivens, A C, Parkinson, J, Rajandream, M A, Shirley, M W, Wan, K L, Berriman, M, Tomley, F M & Pain, A 2014, ' Genomic analysis of the causative agents of coccidiosis in domestic chickens ', Genome Research, vol. 24, no. 10, pp. 1676-1685 . https://doi.org/10.1101/gr.168955.113
Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9faa68d3496e8ba02ecb9906cdad106d
https://eprints.gla.ac.uk/148010/1/148010.pdf
https://eprints.gla.ac.uk/148010/1/148010.pdf
Publikováno v:
Molecular and Biochemical Parasitology. 107:91-102
Microneme organelles are present in all apicomplexan protozoa and contain proteins that are critical for parasite motility and host cell invasion. One apicomplexan-wide family of microneme proteins has been identified with members that are characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb37a6834897853e6f01c87304188396
https://doi.org/10.1016/s0166-6851(00)00179-1
https://doi.org/10.1016/s0166-6851(00)00179-1
Publikováno v:
Molecular and Biochemical Parasitology. 79:195-206
A 50 kDa acidic protein, which is found within the microneme organelles of Eimeria tenella sporozoites and merozoites and called E. tenella mic-2, was cloned by immunoscreening of a cDNA expression library. The expression of the protein and its mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2e6764bbec946aa01c3a0bcb7ea982
https://doi.org/10.1016/0166-6851(96)02662-x
https://doi.org/10.1016/0166-6851(96)02662-x
Publikováno v:
Molecular and Biochemical Parasitology. 70:211-215
Heat-shock protein (hsp) are a large and ubiquitous family of polypeptides which have been well conserved in evolution and which have a number of cellular roles [1,2]. They are known to ‘chaperone’ the transport, folding and assembly of precursor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c42a4e47d3fa21afe89999775f576c
https://doi.org/10.1016/0166-6851(95)00014-r
https://doi.org/10.1016/0166-6851(95)00014-r
Autor:
Puay Eng Soon, Julie D. Clark, Karen J. Billington, Janene M. Bumstead, Paul Sopp, Darner P. Blake, Fiona M. Tomley, Richard D. Oakes
Publikováno v:
Molecular and biochemical parasitology. 162(1)
Stable transfection of Eimeria species has been difficult to achieve because of the obligate requirement for in vivo amplification and selection of the parasites. Strategies to generate and stabilise populations of transfected Eimeria tenella are des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f092c588783883efeb52e067ebe5507
https://pubmed.ncbi.nlm.nih.gov/18723051
https://pubmed.ncbi.nlm.nih.gov/18723051
Autor:
Arnaud Kerhornou, Tiago José Pascoal Sobreira, Mohd Noor Mat Isa, M W Shirley, Marie Adele Rajandream, King Hwa Ling, Soon Joo Yap, Wai Y. Yee, Kiew Lian Wan, Karen Mungall, Sarah E. White, Alan Mitchell Durham, Damer P. Blake, Mariana Nor Shamsudin, Michael A. Quail, Arthur Gruber, Rozita Rosli, Alasdair Ivens, Pierre Rivailler, Shu S. Loo, Rahmah Mohamed, Xikun Wu, Fionnadh Carroll, Siew F. Wai, Fiona M. Tomley, Alan T. Bankier, Paul H. Dear, Jeniffer Novaes, Matthew Berriman, Karen J. Billington, Nick T. Peters, Alda Maria Backx Noronha Madeira, Adrian Tivey
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Eimeria tenella is an intracellular protozoan parasite that infects the intestinal tracts of domestic fowl and causes coccidiosis, a serious and sometimes lethal enteritis. Eimeria falls in the same phylum (Apicomplexa) as several human and animal pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b97771b0e21e8cafd7556aa8672d2d
Publikováno v:
International journal for parasitology. 31(12)
Micronemes are specialised secretory organelles that release their proteins by a stimulus-coupled exocytosis that occurs when apicomplexan parasites make contact with target host cells. These proteins play crucial roles in motility and invasion, most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b9b4c2d230e017a685659ec7a63c0c
https://pubmed.ncbi.nlm.nih.gov/11566298
https://pubmed.ncbi.nlm.nih.gov/11566298